Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization

IF 20.6 1区医学 Q1 MICROBIOLOGY Cell host & microbe Pub Date : 2024-09-17 DOI:10.1016/j.chom.2024.08.014

Zhi Yi Fang, Sara A. Stickley, Amirthagowri Ambalavanan, Yang Zhang, Amanda M. Zacharias, Kelsey Fehr, Shirin Moossavi, Charisse Petersen, Kozeta Miliku, Piushkumar J. Mandhane, Elinor Simons, Theo J. Moraes, Malcolm R. Sears, Michael G. Surette, Padmaja Subbarao, Stuart E. Turvey, Meghan B. Azad, Qingling Duan

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Abstract

The human milk microbiota (HMM) is thought to influence the long-term health of offspring. However, its role in asthma and atopy and the impact of host genomics on HMM composition remain unclear. Through the CHILD Cohort Study, we followed 885 pregnant mothers and their offspring from birth to 5 years and determined that HMM was associated with maternal genomics and prevalence of childhood asthma and allergic sensitization (atopy) among human milk-fed infants. Network analysis identified modules of correlated microbes in human milk that were associated with subsequent asthma and atopy in preschool-aged children. Moreover, reduced alpha-diversity and increased Lawsonella abundance in HMM were associated with increased prevalence of childhood atopy. Genome-wide association studies (GWASs) identified maternal genetic loci (e.g., ADAMTS8, NPR1, and COTL1) associated with HMM implicated with asthma and atopy, notably Lawsonella and alpha-diversity. Thus, our study elucidates the role of host genomics on the HMM and its potential impact on childhood asthma and atopy.

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母乳微生物群网络与宿主基因组学、儿童哮喘和过敏致敏有关

母乳微生物群（HMM）被认为会影响后代的长期健康。然而，它在哮喘和过敏症中的作用以及宿主基因组学对 HMM 组成的影响仍不清楚。我们通过儿童队列研究（CHILD Cohort Study）对 885 名怀孕母亲及其后代进行了从出生到 5 岁的跟踪研究，确定了 HMM 与母体基因组学以及母乳喂养婴儿的儿童哮喘和过敏致敏（atopy）发病率有关。网络分析确定了人乳中与学龄前儿童日后哮喘和过敏相关的微生物模块。此外，人乳中α-多样性的减少和劳森氏菌丰度的增加与儿童过敏症发病率的增加有关。全基因组关联研究（GWAS）发现了与哮喘和过敏症相关的母体遗传位点（如 ADAMTS8、NPR1 和 COTL1），特别是劳森菌和α-多样性。因此，我们的研究阐明了宿主基因组学对 HMM 的作用及其对儿童哮喘和过敏症的潜在影响。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.