Felipe Gomes Naveca, Tatiana Amaral Pires de Almeida, Victor Souza, Valdinete Nascimento, Dejanane Silva, Fernanda Nascimento, Matilde Mejía, Yasmin Silva de Oliveira, Luisa Rocha, Natana Xavier, Janis Lopes, Rodrigo Maito, Cátia Meneses, Tatyana Amorim, Luciana Fé, Fernanda Sindeaux Camelo, Samyly Coutinho de Aguiar Silva, Alexsandro Xavier de Melo, Leíse Gomes Fernandes, Marco Aurélio Almeida de Oliveira, Ana Ruth Arcanjo, Guilherme Araújo, Walter André Júnior, Renata Lia Coragem de Carvalho, Rosiane Rodrigues, Stella Albuquerque, Cristiane Mattos, Ciciléia Silva, Aline Linhares, Taynã Rodrigues, Francy Mariscal, Márcia Andréa Morais, Mayra Marinho Presibella, Nelson Fernando Quallio Marques, Anne Paiva, Karina Ribeiro, Deusilene Vieira, Jackson Alves da Silva Queiroz, Ana Maísa Passos-Silva, Lígia Abdalla, João Hugo Santos, Regina Maria Pinto de Figueiredo, Ana Cecília Ribeiro Cruz, Livia Neves Casseb, Jannifer Oliveira Chiang, Livia Vinhal Frutuoso, Agata Rossi, Lucas Freitas, Túlio de Lima Campos, Gabriel Luz Wallau, Emerson Moreira, Roberto Dias Lins Neto, Laura W. Alexander, Yining Sun, Ana Maria Bispo de Filippis, Tiago Gräf, Ighor Arantes, Ana I. Bento, Edson Delatorre, Gonzalo Bello
{"title":"Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region","authors":"Felipe Gomes Naveca, Tatiana Amaral Pires de Almeida, Victor Souza, Valdinete Nascimento, Dejanane Silva, Fernanda Nascimento, Matilde Mejía, Yasmin Silva de Oliveira, Luisa Rocha, Natana Xavier, Janis Lopes, Rodrigo Maito, Cátia Meneses, Tatyana Amorim, Luciana Fé, Fernanda Sindeaux Camelo, Samyly Coutinho de Aguiar Silva, Alexsandro Xavier de Melo, Leíse Gomes Fernandes, Marco Aurélio Almeida de Oliveira, Ana Ruth Arcanjo, Guilherme Araújo, Walter André Júnior, Renata Lia Coragem de Carvalho, Rosiane Rodrigues, Stella Albuquerque, Cristiane Mattos, Ciciléia Silva, Aline Linhares, Taynã Rodrigues, Francy Mariscal, Márcia Andréa Morais, Mayra Marinho Presibella, Nelson Fernando Quallio Marques, Anne Paiva, Karina Ribeiro, Deusilene Vieira, Jackson Alves da Silva Queiroz, Ana Maísa Passos-Silva, Lígia Abdalla, João Hugo Santos, Regina Maria Pinto de Figueiredo, Ana Cecília Ribeiro Cruz, Livia Neves Casseb, Jannifer Oliveira Chiang, Livia Vinhal Frutuoso, Agata Rossi, Lucas Freitas, Túlio de Lima Campos, Gabriel Luz Wallau, Emerson Moreira, Roberto Dias Lins Neto, Laura W. Alexander, Yining Sun, Ana Maria Bispo de Filippis, Tiago Gräf, Ighor Arantes, Ana I. Bento, Edson Delatorre, Gonzalo Bello","doi":"10.1038/s41591-024-03300-3","DOIUrl":null,"url":null,"abstract":"<p>The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. Here, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia, and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia, and Ecuador (2008-2021). The novel reassortant likely emerged in the Amazonas state between 2010 and 2014 and spread through long-range dispersion events during the second half of the 2010s. Phylodynamics reconstructions showed that the current OROV spread was mainly driven by short-range (< 2 km) movements consistent with the flight range of vectors. Nevertheless, a substantial proportion (22%) of long-range (> 10 km) OROV migrations were also detected, consistent with viral dispersion by humans. Our data provides a view of the unprecedented spread and evolution of OROV in Brazilian western Amazon region.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":null,"pages":null},"PeriodicalIF":58.7000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41591-024-03300-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. Here, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia, and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia, and Ecuador (2008-2021). The novel reassortant likely emerged in the Amazonas state between 2010 and 2014 and spread through long-range dispersion events during the second half of the 2010s. Phylodynamics reconstructions showed that the current OROV spread was mainly driven by short-range (< 2 km) movements consistent with the flight range of vectors. Nevertheless, a substantial proportion (22%) of long-range (> 10 km) OROV migrations were also detected, consistent with viral dispersion by humans. Our data provides a view of the unprecedented spread and evolution of OROV in Brazilian western Amazon region.
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