{"title":"Recent Advances in Visible-Light-Mediated Synthesis of Phosphorylated Heterocycles","authors":"Fan-lin Zeng, Zhenhua Jia, Teck-Peng Loh","doi":"10.1002/adsc.202400819","DOIUrl":null,"url":null,"abstract":"<p>Organophosphorus compounds, especially phosphorylated heterocycles, are gaining increasing attention in the fields of materials science, pharmaceuticals, and agrochemistry due to their excellent biological activities. Consequently, the exploration of green and efficient methods for the synthesis of phosphorylated heterocycles has garnered significant interest from organic chemists. In recent years, visible light-induced photoredox-catalyzed organic synthesis has made substantial progress in the field of phosphorylation reaction since its eco-friendly and mild conditions. This review summarizes the advances of the past five years in the visible-light-mediated synthesis of phosphorylated heterocycles using phosphine oxides as precursors through P-centered radical addition, cross-coupling, and cyclization reactions.</p>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"366 22","pages":"4536-4547"},"PeriodicalIF":4.0000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.202400819","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Organophosphorus compounds, especially phosphorylated heterocycles, are gaining increasing attention in the fields of materials science, pharmaceuticals, and agrochemistry due to their excellent biological activities. Consequently, the exploration of green and efficient methods for the synthesis of phosphorylated heterocycles has garnered significant interest from organic chemists. In recent years, visible light-induced photoredox-catalyzed organic synthesis has made substantial progress in the field of phosphorylation reaction since its eco-friendly and mild conditions. This review summarizes the advances of the past five years in the visible-light-mediated synthesis of phosphorylated heterocycles using phosphine oxides as precursors through P-centered radical addition, cross-coupling, and cyclization reactions.
有机磷化合物，尤其是磷酸化杂环，因其卓越的生物活性，在材料科学、医药和农业化学领域日益受到关注。因此，探索合成磷酸化杂环的绿色高效方法引起了有机化学家的极大兴趣。近年来，可见光诱导的光氧化催化有机合成因其环保、温和的条件，在磷酸化反应领域取得了长足的进步。本综述总结了过去五年中以膦氧化物为前驱体，通过 P 中心自由基加成、交叉缩合和环化反应，在可见光介导下合成磷酸化杂环方面取得的进展。
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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