Difuropyridines have been prepared from aldehydes and chitin-derived 3-acetamidofuran (3AF) under acid-catalyzed conditions. Difuropyridines were comprehensively synthesized for the first time. The synthesized difuropyridines can be applied to prepare fluorescent probe analogs or catalyze decarboxylative reactions as photocatalysts.
The combination of palladium and silver complexes has emerged as a bimetallic catalytic system in C−H activation, frequently outperforming palladium-only systems. Beyond the conventional roles of silver (I) salts serving as oxidants, halide scavengers, and Lewis acids, Pd−Ag bimetallic synergism has been shown to facilitate C−H cleavage. In this study, we explore the incorporation of a pyrazolopyridone (PzPyOH) ligand into a Pd−Ag bimetallic catalytic system, which together promote both C−H cleavage and migratory insertion processes. This synergistic approach enables dehydrogenative C−H alkenylations at the C4 position of 2,1,3-benzothiadiazole, 2,1,3-benzoxadiazole, and 2,1,3-benzotriazole with alkenes. These results demonstrate the potential of combining novel ligands with heterobimetallic systems to facilitate other elementary steps beyond C−H cleavage, suggesting their broader applicability in C−H functionalization.
The front cover presents the conversion of simple benzene derivatives into high-value trifluoromethyl-containing cyclohexadienes. The background shows the gate of Qiushi Academy, which is the former site of Zhejiang University. With a chromium-mediated η6-coordination strategy to activate inert arene π-bonds, both dearomative 1,2-hydrotrifluoromethylation and dearomative 1,2-deuterotrifluoromethylation were readily realized. More details can be found in the Communication by Wei Li and co-workers (C.-J. Wu, X. Jiang, J.-Y. Qiu, M.-Y. Wang, W. Li, Adv. Synth. Catal. 2024, 366, 4195–4199; DOI: 10.1002/adsc.202400718)
The front cover illustrates the dual role of the “Magic Blue” molecule. Set in an enchanting forest, a whimsical wizard conjures two gold complexes in a magical cauldron full of “Magic Blue”. The compounds react via chloride abstraction for the [AuCl(JohnPhos)] catalyst and one-electron oxidation for the ferrocenyl imine-phosphane catalyst. Fairies are depicted pulling a chloride atom and an electron, respectively, showcasing the dynamic nature that “Magic Blue” oxidant can adopt depending on the molecule it reacts with. Details can be found in Research Article by Pérez-Sánchez, Herrera, and Gimeno (J. C. Pérez-Sánchez, R. P. Herrera, M. C. Gimeno, Adv. Synth. Catal. 2024, 366, 3697–3924; DOI: 10.1002/adsc.202400593)
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