Soy lysolecithin prevents hypertension and cognitive impairment induced in mice by high salt intake by inhibiting intestinal inflammation

IF 4.4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Neurochemistry international Pub Date : 2024-09-12 DOI:10.1016/j.neuint.2024.105858
Hisayoshi Kubota , Kazuo Kunisawa , Masaya Hasegawa , Hitomi Kurahashi , Kazuhiro Kagotani , Yuki Fujimoto , Akihito Hayashi , Ryoji Sono , Takehiko Tsuji , Kuniaki Saito , Toshitaka Nabeshima , Akihiro Mouri
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引用次数: 0

Abstract

High salt (HS) intake induces hypertension and cognitive impairment. Preventive strategies include against dietary supplements. Soybean lecithin is a widely used phospholipid supplement. Lysolecithin is important in cell signaling, digestion, and absorption. This study aimed to investigate the effects of lysophosphatidylcholine containing >70% of the total phospholipids (LPC70), on hypertension and cognitive impairment induced in mice by HS intake. Mice were provided with HS solution (2% NaCl in drinking water) with or without LPC70 for 12 weeks. Blood pressure, cognitive function, and inflammatory response of intestine were determined. Hypertension and impaired object recognition memory induced by HS intake were implicated with increased inducible nitric oxide synthase in the small intestine and tau hyperphosphorylation in the prefrontal cortex. LPC70 treatment prevented cognitive impairment by suppressing inducible nitric oxide synthase and tau hyperphosphorylation. LPC70 may be valuable as a functional food component in preventing HS-induced cognitive impairment.

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大豆卵磷脂通过抑制肠道炎症预防高盐摄入诱发的小鼠高血压和认知障碍
高盐(HS)摄入会诱发高血压和认知障碍。预防策略包括反对膳食补充剂。大豆卵磷脂是一种广泛使用的磷脂补充剂。卵磷脂在细胞信号传导、消化和吸收方面具有重要作用。本研究旨在探讨含磷脂总量 70% 的溶血磷脂酰胆碱(LPC70)对摄入 HS 引起的小鼠高血压和认知障碍的影响。向小鼠提供含或不含 LPC70 的 HS 溶液(饮用水中含 2% NaCl),持续 12 周。对小鼠的血压、认知功能和肠道炎症反应进行了测定。摄入 HS 引起的高血压和物体识别记忆受损与小肠中诱导型一氧化氮合酶增加和前额叶皮层中 tau 过度磷酸化有关。LPC70 治疗可抑制诱导型一氧化氮合酶和 tau 过度磷酸化,从而防止认知障碍。LPC70作为一种功能性食品成分,在预防HS诱导的认知障碍方面可能具有重要价值。
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来源期刊
Neurochemistry international
Neurochemistry international 医学-神经科学
CiteScore
8.40
自引率
2.40%
发文量
128
审稿时长
37 days
期刊介绍: Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.
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