Combination of porous Se@SiO2 nanospheres and docetaxel exhibits anti-castration-resistant prostate cancer activity by downregulating ATG14-dependent autophagy
{"title":"Combination of porous Se@SiO2 nanospheres and docetaxel exhibits anti-castration-resistant prostate cancer activity by downregulating ATG14-dependent autophagy","authors":"","doi":"10.1016/j.nantod.2024.102499","DOIUrl":null,"url":null,"abstract":"<div><p>Chemotherapy remains the core anticancer treatment for castration-resistant prostate cancer (CRPC). However, drug resistance still poses a major obstacle, leading to shorter survival times. Given the biosafety of porous Se@SiO<sub>2</sub> nanospheres in normal tissues, their combination with chemotherapeutic drugs has emerged as an effective treatment for cancer. It is unknown whether porous Se@SiO<sub>2</sub> nanospheres can protect CRPC cells from drug resistance. In our study, we synthesized porous Se@SiO<sub>2</sub> nanospheres and confirmed their characteristics in line with previous studies. We discovered that porous Se@SiO<sub>2</sub> nanospheres sensitize CRPC to docetaxel (DTX) treatment, both <em>in vitro</em> and <em>in vivo</em>. Mechanistically, the nanospheres induce dephosphorylation of autophagy-related 14 (ATG14) at Y357 by upregulating the expression of the cellular form of prostatic acid phosphatase (cPAP) protein, which prevents the induction of autophagy and the survival of prostate cancer cells after DTX treatment. Furthermore, there is a negative correlation between cPAP and autophagy in CRPC. Our results suggest that the combination of porous Se@SiO<sub>2</sub> nanospheres with DTX could be a potentially effective treatment for CRPC.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1748013224003554/pdfft?md5=10bece42a14811e866fd7cec1aca59ff&pid=1-s2.0-S1748013224003554-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224003554","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Chemotherapy remains the core anticancer treatment for castration-resistant prostate cancer (CRPC). However, drug resistance still poses a major obstacle, leading to shorter survival times. Given the biosafety of porous Se@SiO2 nanospheres in normal tissues, their combination with chemotherapeutic drugs has emerged as an effective treatment for cancer. It is unknown whether porous Se@SiO2 nanospheres can protect CRPC cells from drug resistance. In our study, we synthesized porous Se@SiO2 nanospheres and confirmed their characteristics in line with previous studies. We discovered that porous Se@SiO2 nanospheres sensitize CRPC to docetaxel (DTX) treatment, both in vitro and in vivo. Mechanistically, the nanospheres induce dephosphorylation of autophagy-related 14 (ATG14) at Y357 by upregulating the expression of the cellular form of prostatic acid phosphatase (cPAP) protein, which prevents the induction of autophagy and the survival of prostate cancer cells after DTX treatment. Furthermore, there is a negative correlation between cPAP and autophagy in CRPC. Our results suggest that the combination of porous Se@SiO2 nanospheres with DTX could be a potentially effective treatment for CRPC.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.