Nano Today最新文献

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Corrigendum to “Achieving apoptosis/cuproptosis co-activated synergistic anti-tumor therapy by charges transport engineering” [Nano Today, 62 (2025), 102689] “通过电荷传输工程实现细胞凋亡/铜细胞共激活的协同抗肿瘤治疗”的更正[纳米今日，62 (2025),102689]

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 DOI: 10.1016/j.nantod.2025.102959

Hua-Ying Hou , Xu Chu , Meng-Die Duan , Yu-Juan Zhang , Hong-Li Chen , Yue Sun , Yi Liu , Shu-Lan Li

引用次数: 0

Corrigendum to “Nanosynergist-engineered oncolytic adenovirus enhancing immune-virotherapy efficacy for glioblastoma via interrupting antiviral responses” [Nano Today 57 (2024) 102328] “纳米增效剂工程溶瘤腺病毒通过中断抗病毒反应增强胶质母细胞瘤的免疫病毒治疗效果”的更正[Nano Today 57 (2024) 102328]

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 DOI: 10.1016/j.nantod.2025.102970

Jinliang Xu , Xiaoxiao Liu , Junqiang Ding , Hanchang Zhang , Tingting Yao , Sha Li , Rong Yang , Nianhui Yu , Qi Yue , Changyou Zhan , Xihui Gao

引用次数: 0

Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page 封底内-图解摘要TOC/TOC双栏，如果需要，从OBC继续，否则空白页

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 DOI: 10.1016/S1748-0132(26)00019-8

引用次数: 0

Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information 封底外-图形摘要TOC/双栏TOC/封面图例（如适用），条形码，摘要和索引信息

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 DOI: 10.1016/S1748-0132(26)00020-4

引用次数: 0

Dual metabolic restructuring against tumor acidosis and adenosine potentiates radioimmunotherapy via reinvigoration of CD8+ T lymphocytes 双重代谢重组对抗肿瘤酸中毒和腺苷增强放射免疫治疗通过CD8+ T淋巴细胞的活化

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-01-31 DOI: 10.1016/j.nantod.2026.102997

Hao Jiang , Xin Wang , Xianzhou Cai , Jinqiao Zhang , Fangong Kong , Qin Fan , Ziliang Dong

Tumor acidosis and adenosine (ADO) accumulation are key metabolic aberrations that drive T cell exhaustion, suppress cytotoxicity, and confer radioresistance, posing a major obstacle for solid tumor therapy. To address this, we designed pH-responsive layered double hydroxide nanosheets loaded with the CD73 inhibitor PSB-12379 (denoted as LDH@PSB) for concurrent acidosis neutralization and ADO blockade. The nanosheets rapidly degraded under mildly acidic conditions (pH ∼6.5), elevating extracellular pH and releasing PSB-12379 to inhibit radiation-induced CD73 upregulation and ADO production. This dual intervention restored T cell function by increasing cytotoxic mediator expression (e.g., IFN-γ, granzyme B) and reducing exhaustion markers (e.g., PD-1, TIGIT). Meanwhile, Mn²⁺ ions released from LDH@PSB activated the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, synergizing with radiotherapy-induced immunogenic cell death to boost antitumor immunity. In murine B16F10 melanoma and CT26 colon carcinoma models, LDH@PSB with radiotherapy markedly inhibited tumor growth, prolonged survival, and increased tumor-infiltrating CD8⁺ T cells with enhanced cytotoxicity. Combination with anti-PD-1 therapy further induced systemic immunity to eradicate distant tumors. This strategy simultaneously alleviates tumor acidosis, disrupts ADO-mediated immunosuppression, and activates cGAS-STING signaling, offering a potent approach to enhance radioimmunotherapy.

肿瘤酸中毒和腺苷（ADO）积累是导致T细胞衰竭、抑制细胞毒性和产生放射耐药的关键代谢异常，是实体瘤治疗的主要障碍。为了解决这个问题，我们设计了负载CD73抑制剂PSB-12379（表示为LDH@PSB）的ph响应层状双氢氧化物纳米片，用于同时中和酸中毒和阻断ADO。纳米片在轻度酸性条件下（pH ~ 6.5）迅速降解，升高细胞外pH并释放PSB-12379以抑制辐射诱导的CD73上调和ADO产生。这种双重干预通过增加细胞毒性介质的表达（如IFN-γ、颗粒酶B）和减少衰竭标志物（如PD-1、TIGIT）来恢复T细胞功能。同时，LDH@PSB释放的Mn2 +离子激活了干扰素基因环GMP-AMP合成酶刺激因子（cGAS-STING）通路，与放疗诱导的免疫原性细胞死亡协同作用，增强抗肿瘤免疫。在小鼠B16F10黑色素瘤和CT26结肠癌模型中，LDH@PSB配合放疗可显著抑制肿瘤生长，延长生存期，增加肿瘤浸润性CD8 + T细胞，增强细胞毒性。联合抗pd -1治疗进一步诱导全身免疫根除远处肿瘤。该策略同时缓解了肿瘤酸中毒，破坏了ado介导的免疫抑制，激活了cGAS-STING信号，为增强放射免疫治疗提供了一种有效的方法。

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引用次数: 0

Fluorinated amphipathic cationic peptides for intracellular protein delivery and cancer immunotherapy 用于细胞内蛋白传递和癌症免疫治疗的氟化两性阳离子肽

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-01-24 DOI: 10.1016/j.nantod.2026.102979

Wenhua Cheng , Yan Lou , Yiyun Cheng , Xin Gao , Quan Huang

Cell penetrating peptides are widely developed as carriers to transport proteins inside cells, but there remain some drawbacks such as limited protein loading capacity and nanoparticle stability, endosomal escape and intracellular delivery efficacy. Herein, we design a family of fluorinated amphipathic cationic peptides (FACPs) to address these issues. A library of amphipathic cationic hexapeptides is conjugated with a fluorous tag at the C-terminus via a dynamic hydrazone bond. Among the investigated materials, FACP2 (peptide sequence: RRRWWW) demonstrates the optimal performance in protein binding, cellular uptake, endosomal escape, and thus intracellular delivery efficacy. It efficiently delivers ovalbumin into bone marrow derived dendritic cells and stimulates their maturation, enhancing the antigen cross-presentation both in vitro and in vivo. As a result, the FACP2/ovalbumin nanovaccine effectively inhibits the tumor growth in mice when combined with anti-PD1 therapy or co-delivered with the STING agonist 2′,3′-cyclic guanosine monophosphate. This study provides a highly efficient peptide nanocarrier for cytosolic protein delivery and cancer immunotherapy through antigen and adjuvant co-delivery.

细胞穿透肽作为蛋白质在细胞内运输的载体被广泛开发，但仍存在一些缺陷，如蛋白质装载能力和纳米颗粒稳定性有限，内体逃逸和细胞内递送效率等。在这里，我们设计了一个氟化两亲阳离子肽（FACPs）家族来解决这些问题。两亲性阳离子六肽库通过动态腙键在c端与含氟标签偶联。在所研究的材料中，FACP2（肽序列：RRRWWW）在蛋白质结合、细胞摄取、内体逃逸以及细胞内递送方面表现最佳。它能有效地将卵清蛋白输送到骨髓来源的树突状细胞中并刺激其成熟，增强抗原在体外和体内的交叉呈递。因此，FACP2/卵清蛋白纳米疫苗与抗pd1治疗联合或与STING激动剂2 ',3 ' -环鸟苷单磷酸共递送时，可有效抑制小鼠肿瘤生长。本研究提供了一种高效的多肽纳米载体，通过抗原和佐剂的共同递送，用于细胞内蛋白的递送和癌症的免疫治疗。

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引用次数: 0

Modulating the inverse VC/Pd heterostructure for high-performance electrocatalytic methanol oxidation 高性能电催化甲醇氧化中VC/Pd逆异质结构的调控

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-01-22 DOI: 10.1016/j.nantod.2026.102986

Ting Wu , Haolin Li , Wei Zhang , Jie Liu , Junning Zhao , Jialin Zhao , Shuangfei Cai , Rong Yang , Zhiyong Tang

Design of effective methanol oxidation reaction (MOR) electrocatalysts with fast reaction kinetics and exceptional CO resistance remains a grand challenge. Herein, we report an electron-restructuring strategy based on an inverse interfacial structure, by decorating the vanadium carbide nanoclusters (VC NCs) on hexagonal Pd nanosheets (NSs) for efficient MOR. The VC-decorated Pd NSs evolve into unique mulberry leaf-like structures (NMLs) with the jagged edges, enhancing active sites exposure and interfacial charge transfer. The VC_0.01/Pd NMLs exhibit high mass activity (1768.44 A g_Pd⁻¹), 23.6 and 6.4 times higher than Pd NSs and commercial Pd/C catalyst, respectively. The VC_0.01/Pd NMLs also show high tolerance to CO poisoning. Theoretical calculations further reveal a strong VC-Pd interfacial interaction, modulating the Pd’s d-band center, reducing CO* adsorption, and enhancing OH* generation. The work shows that the construction of inverse VC-Pd interfaces is an effective approach to improve electrocatalytic performance of Pd catalysts for MOR.

设计高效的甲醇氧化反应（MOR）电催化剂，具有快速反应动力学和优异的CO抗性，仍然是一个巨大的挑战。在此，我们报道了一种基于逆界面结构的电子重组策略，通过在六边形钯纳米片（NSs）上装饰碳化钒纳米团簇（VC - NCs）来实现高效的MOR。vc修饰的Pd NSs形成独特的桑叶状结构（NMLs），边缘呈锯齿状，增强了活性位点的暴露和界面电荷转移。VC0.01/Pd NMLs具有较高的质量活性（1768.44 A gPd−1），分别是Pd NSs和商用Pd/C催化剂的23.6倍和6.4倍。VC0.01/Pd的NMLs对CO中毒也表现出较高的耐受性。理论计算进一步揭示了VC-Pd的强界面相互作用，调节了Pd的d波段中心，减少了CO*的吸附，增强了OH*的生成。研究表明，构建VC-Pd逆界面是提高Pd催化剂MOR电催化性能的有效途径。

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引用次数: 0

Gold nanoclusters - A promising atomically precise atomic aggregation-based drug and its biomedical applications 金纳米团簇——一种很有前途的基于原子精确原子聚集的药物及其生物医学应用

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-01-21 DOI: 10.1016/j.nantod.2026.102985

Chao Xu , Yuan Zhang , Chunyu Zhang , Xueyun Gao

Gold nanoclusters (Au NCs) are regarded as the most promising nanomedicine due to their precise structure composition, good biocompatibility, faster kidney clearance, and distinctive biological effects. They have demonstrated excellent potential in inhibiting tumors, antiviral, and antibacterial activities, as well as immunomodulatory effects. Simultaneously, the biological effects of Au NCs are significantly impacted by the synthetic strategies employed during their fabrication. In this review article, we have summarized the synthetic strategy used to achieve good biocompatibility of atomically precise Au NCs and highlight their biological effect and potential applications as biomedical drugs. The biological effects of Au NCs can be determined by their structure and composition. Therefore, various synthesis strategies for obtaining biocompatible Au NCs are summarized. Their physicochemical properties, biosafety, and metabolic characteristics are also discussed. Secondly, we explore the biomedical applications of Au NCs in therapeutics and drug delivery, highlighting the opportunities they present for antitumor, antiviral, antibacterial, and immune regulation applications. Finally, we provide an outlook on the current status and future efforts surrounding the synthesis and biomedical applications of Au NCs. We hope this review article will provide a comprehensive synthetic strategy to obtain the atomically precise Au NCs with good biocompatibility and give a comprehensive understanding of their biomedical application.

金纳米团簇（Au NCs）由于其精确的结构组成、良好的生物相容性、快速的肾脏清除和独特的生物效应而被认为是最有前途的纳米药物。它们在抑制肿瘤、抗病毒和抗菌活性以及免疫调节作用方面表现出良好的潜力。同时，金纳米材料的生物学效应也受到其制备过程中所采用的合成策略的显著影响。本文综述了原子精密金纳米材料的合成策略，并重点介绍了其生物效应和作为生物医学药物的潜在应用前景。金纳米化合物的生物学效应可以通过其结构和组成来确定。因此，综述了获得生物相容性金纳米细胞的各种合成策略。还讨论了它们的理化性质、生物安全性和代谢特性。其次，我们探讨了Au NCs在治疗和药物传递方面的生物医学应用，重点介绍了它们在抗肿瘤、抗病毒、抗菌和免疫调节方面的应用。最后，我们对Au NCs的合成和生物医学应用的现状和未来的努力进行了展望。我们希望通过本文的综述，为获得具有良好生物相容性的原子精度的Au纳米材料提供一个综合的合成策略，并对其生物医学应用有一个全面的了解。

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引用次数: 0

Puerarin-loaded hyaluronic acid self-assembled nanoparticles ameliorate hyperuricemic nephropathy by modulating lipid peroxidation and macrophage polarization 葛根素透明质酸自组装纳米颗粒通过调节脂质过氧化和巨噬细胞极化改善高尿酸血症肾病

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-01-19 DOI: 10.1016/j.nantod.2026.102983

Mu-xuan Wang , Ying-ying Chen , Shu-tao Sun , Mohamed A. Farag , Zhi-yong Zhao , Shi-hai Lu , Min-hsiung Pan , Ning-yang Li , Xu Guo , Chao Liu

Hyperuricemic nephropathy (HUN) is a chronic kidney disease, as featured by the large amount of uric acid (UA) deposited in the kidney. Lipid peroxidation and macrophage infiltration caused by UA are two prominent risk factors linked in the occurrence of HUN. Puerarin (PEA) has anti-hyperuricemia, antioxidant, and anti-inflammatory activity, albeit the poor water solubility and a short half-life limit its application. To improve the bioavailability of PEA, this study prepared PEA-loaded hyaluronic acid (HA) self-assembled nanoparticles (PEA-HA NPs). Release kinetics showed that PEA-HA NPs achieved the pH-responsive sustained-release in the weakly acidic microenvironment of HUN. In vivo biodistribution indicated that PEA-HA NPs was preferably internalized by renal tubular epithelial cells in HUN, which was attributed to the specific binding between HA and CD44 receptor. In vitro health benefits confirmed that PEA-HA NPs modulated lipid peroxidation though a distinctive four-pronged strategy in UA-induced HK-2 cells, including scavenging ROS, restoration of mitochondrial function, regulation of inflammatory pathways, and inhibition of apoapsis. Likewise, PEA-HA NPs could transform the pro-inflammatory macrophages (M1-type) of into anti-inflammatory macrophages (M2-type), thereby inhibiting UA-caused macrophage infiltration. In vivo analysis also showed that PEA-HA NPs could alleviate renal dysfunction and fibrosis by modulating lipid peroxidation and macrophage polarization. This study improves the bioavailability and long-lasting therapeutic duration of PEA, which provides a convenient strategy for the efficient treatment of HUN.

高尿酸血症肾病（HUN）是一种慢性肾脏疾病，以大量尿酸（UA）沉积在肾脏为特征。UA引起的脂质过氧化和巨噬细胞浸润是HUN发生的两个重要危险因素。葛根素（PEA）具有抗高尿酸血症、抗氧化和抗炎活性，但其水溶性差和半衰期短限制了其应用。为了提高PEA的生物利用度，本研究制备了PEA负载透明质酸（HA）自组装纳米粒子（PEA-HA NPs）。释放动力学表明，PEA-HA NPs在弱酸性微环境中实现ph响应缓释。体内生物分布表明，PEA-HA NPs在HUN中更容易被肾小管上皮细胞内化，这与HA与CD44受体的特异性结合有关。体外健康益处证实，PEA-HA NPs通过一种独特的四管齐下的策略，在ua诱导的HK-2细胞中调节脂质过氧化，包括清除ROS、恢复线粒体功能、调节炎症途径和抑制凋亡。同样，PEA-HA NPs可以将促炎巨噬细胞（m1型）转化为抗炎巨噬细胞（m2型），从而抑制ua引起的巨噬细胞浸润。体内分析也显示PEA-HA NPs通过调节脂质过氧化和巨噬细胞极化来减轻肾功能障碍和纤维化。本研究提高了PEA的生物利用度和持久的治疗持续时间，为有效治疗HUN提供了方便的策略。

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Toward climate-resilient and fire-safe buildings: Multifunctional surface materials integrating radiative cooling and flame retardancy 面向气候适应性和防火安全建筑：集辐射冷却和阻燃于一体的多功能表面材料

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-01-19 DOI: 10.1016/j.nantod.2026.102984

Xueyi Zhao , Yu Lei , Lulu Xu , Anthony Chun Yin Yuen , Ying Pan , Vipul Agarwal , Yao Yuan , Wei Cai , Kate T.Q. Nguyen , Guan Heng Yeoh , Wei Wang

Amid the escalating urban heat island effects and increasing fire hazards driven by climate change and rapid urbanization, buildings face two parallel challenges: excessive heat accumulation and heightened fire vulnerability. Multifunctional surface materials that integrate passive radiative cooling (PRC) and flame retardant (FR) have emerged as promising solutions for enhancing both energy efficiency and fire safety. By synergistically combining PRC and FR functionalities, these materials can reflect solar radiation and emit heat to reduce surface temperatures, while simultaneously inhibiting ignition, slowing flame spread, and suppressing toxic smoke via gas-phase and condensed-phase mechanisms. This review presents a comprehensive overview of their working principles, performance evaluation methods, and material classifications of such materials, focusing on four main systems: organic polymer-based materials, polymer–inorganic composites, bio-based materials, and other material systems. Particular emphasis is placed on the relationship among materials, structure, and properties, strategies for integrating multifunctionality, and the influence of environmental conditions on long-term performance. Key challenges related to climate adaptability, outdoor durability, and filler dispersion are discussed to guide future research. These materials offer a promising pathway toward energy-efficient, fire-safe, and climate-resilient buildings.

在气候变化和快速城市化推动下，城市热岛效应不断加剧，火灾风险不断增加，建筑面临着热量过度积累和火灾脆弱性加剧的双重挑战。集成被动辐射冷却（PRC）和阻燃剂（FR）的多功能表面材料已成为提高能源效率和消防安全的有前途的解决方案。通过协同结合PRC和FR功能，这些材料可以反射太阳辐射并释放热量以降低表面温度，同时抑制点火，减缓火焰蔓延，并通过气相和冷凝相机制抑制有毒烟雾。本文综述了有机高分子材料的工作原理、性能评价方法和材料分类，重点介绍了有机高分子材料、高分子-无机复合材料、生物基材料和其他材料体系。特别强调的是材料、结构和性能之间的关系，整合多功能的策略，以及环境条件对长期性能的影响。讨论了与气候适应性、室外耐久性和填料分散相关的关键挑战，以指导未来的研究。这些材料为节能、防火安全和气候适应性强的建筑提供了一条有希望的途径。

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