Pub Date : 2024-07-01DOI: 10.1016/j.nantod.2024.102383
Zhenwen Zhao , Yulun Chen , Hui Liu , Haitian Tang , Minglei Teng , Xue Liu , Jianlin Ge , Shilong Shao , Zhenjie Li , Tao Jiang , Chao Liu , Xiao Xu , Gang Liu
Trans-arterial radioembolization (TARE) therapy confronts significant technical challenges in the preparation of metal nuclide-labeled microsphere carriers, the development of stable and efficient radionuclide labeling strategies, and the ability to treat multiple small lesions in solid tumors. In this study, we synthesized 177Lu-labeled amidoxime-based polyvinyl alcohol microspheres (177Lu-PVA-g-PAO-Ms) using in situ synthesis of trunk compounds with chem-induced grafting polymerization. The resulting 177Lu-PVA-g-PAO-Ms showed excellent stability in radiolabeling and demonstrated high accumulation and prolonged retention in various preclinical rodent models, as observed through SPECT/CT imaging. The cumulative radioactivity uptake in the tumor reached as high as 12.27 %ID/g. In a mouse subcutaneous metastatic tumor model, we observed a significant abscopal effect of radioimmunotherapy after administering a combination of 177Lu-PVA-g-PAO-Ms and an anti-PD-L1 nanobody. These findings highlight the ability of PVA-g-PAO-Ms to chelate radionuclides efficiently and securely. Furthermore, when combined with nanobodies with enhanced tissue penetration capabilities, these microspheres hold great potential as innovative carrier platforms, offering new therapeutic strategies for integrating TARE with systemic immunotherapy.
{"title":"Amidoxime-based radio-microspheres for Internal Irradiation combined with a checkpoint-blocking nanobody boost antitumor immunity","authors":"Zhenwen Zhao , Yulun Chen , Hui Liu , Haitian Tang , Minglei Teng , Xue Liu , Jianlin Ge , Shilong Shao , Zhenjie Li , Tao Jiang , Chao Liu , Xiao Xu , Gang Liu","doi":"10.1016/j.nantod.2024.102383","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102383","url":null,"abstract":"<div><p>Trans-arterial radioembolization (TARE) therapy confronts significant technical challenges in the preparation of metal nuclide-labeled microsphere carriers, the development of stable and efficient radionuclide labeling strategies, and the ability to treat multiple small lesions in solid tumors. In this study, we synthesized <sup>177</sup>Lu-labeled amidoxime-based polyvinyl alcohol microspheres (<sup>177</sup>Lu-PVA-<em>g</em>-PAO-Ms) using in situ synthesis of trunk compounds with chem-induced grafting polymerization. The resulting <sup>177</sup>Lu-PVA-<em>g</em>-PAO-Ms showed excellent stability in radiolabeling and demonstrated high accumulation and prolonged retention in various preclinical rodent models, as observed through SPECT/CT imaging. The cumulative radioactivity uptake in the tumor reached as high as 12.27 %ID/g. In a mouse subcutaneous metastatic tumor model, we observed a significant abscopal effect of radioimmunotherapy after administering a combination of <sup>177</sup>Lu-PVA-<em>g</em>-PAO-Ms and an anti-PD-L1 nanobody. These findings highlight the ability of PVA-<em>g</em>-PAO-Ms to chelate radionuclides efficiently and securely. Furthermore, when combined with nanobodies with enhanced tissue penetration capabilities, these microspheres hold great potential as innovative carrier platforms, offering new therapeutic strategies for integrating TARE with systemic immunotherapy.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-28DOI: 10.1016/j.nantod.2024.102380
Yongsheng Cui , Jing Liu , Lele Cui , Chaorong Wei , Mingxia Xu , Zhengzhong Wu , Yingkun Guo , Peng Mi
Cancer immunotherapy is generally limited by the low immunogenicity of tumor microenvironments (TME). Thus, regulating immune responses in low immunogenic solid tumors is critical for improving immunotherapeutic outcomes. Here, the tumor-targeting and activatable biomimetic nanococktails have been engineered to synergistically and systemically activate a cascade of immune responses and downregulate immunosuppressive T cells for spatiotemporal immunotherapy of low immunogenic solid tumors. The nanococktails had core-shell structures, where the photosensitizers, STING agonists and indoleamine 2,3-dioxygen-ase 1 (IDO1) inhibitors were encapsulated within the core, which can disassociate when responding to the low pH in tumors to disrupt the particle shells and cellular membranes for precision drug delivery and release. The ligands anchored on the shell of nanococktails could efficiently target the receptors that were identified to be highly expressed in the breast cancer cells, facilitating efficient intracellular drug delivery and synergistically inducing anticancer immunity and mitochondrial damage. By intravenous (i.v.) injection, the nanococktails demonstrated high accumulation in triple-negative breast cancer (TNBC), endowing precision diagnosis and effective elimination of primary TNBC tumors. The synergistic effects of STING activation and metalloimmunotherapy induced by nanococktails can amplify systemic immune responses and downregulate immunosuppressive regulatory T cells (Tregs) in primary tumors, lymph nodes and distant tumors, which spatiotemporally inhibited distant tumors and lung metastasis of TNBC with promoted survival rates. This study presents a promising strategy for leveraging nanococktails to regulate immune responses for effective immunotherapy.
{"title":"Tumor-targeting and activatable biomimetic nanococktails synergistically regulate immune responses for spatiotemporal immunotherapy of low immunogenic solid tumors","authors":"Yongsheng Cui , Jing Liu , Lele Cui , Chaorong Wei , Mingxia Xu , Zhengzhong Wu , Yingkun Guo , Peng Mi","doi":"10.1016/j.nantod.2024.102380","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102380","url":null,"abstract":"<div><p>Cancer immunotherapy is generally limited by the low immunogenicity of tumor microenvironments (TME). Thus, regulating immune responses in low immunogenic solid tumors is critical for improving immunotherapeutic outcomes. Here, the tumor-targeting and activatable biomimetic nanococktails have been engineered to synergistically and systemically activate a cascade of immune responses and downregulate immunosuppressive T cells for spatiotemporal immunotherapy of low immunogenic solid tumors. The nanococktails had core-shell structures, where the photosensitizers, STING agonists and indoleamine 2,3-dioxygen-ase 1 (IDO1) inhibitors were encapsulated within the core, which can disassociate when responding to the low pH in tumors to disrupt the particle shells and cellular membranes for precision drug delivery and release. The ligands anchored on the shell of nanococktails could efficiently target the receptors that were identified to be highly expressed in the breast cancer cells, facilitating efficient intracellular drug delivery and synergistically inducing anticancer immunity and mitochondrial damage. By intravenous (<em>i.v.</em>) injection, the nanococktails demonstrated high accumulation in triple-negative breast cancer (TNBC), endowing precision diagnosis and effective elimination of primary TNBC tumors. The synergistic effects of STING activation and metalloimmunotherapy induced by nanococktails can amplify systemic immune responses and downregulate immunosuppressive regulatory T cells (Tregs) in primary tumors, lymph nodes and distant tumors, which spatiotemporally inhibited distant tumors and lung metastasis of TNBC with promoted survival rates. This study presents a promising strategy for leveraging nanococktails to regulate immune responses for effective immunotherapy.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-28DOI: 10.1016/j.nantod.2024.102381
Wenbo Wang , Pei Wang , Qinlin Li , Wufei Dai, Bingcheng Yi, Zhen Gao, Wei Liu, Xiansong Wang
Tendon injuries, prevalent in clinical settings, predominantly arise from the disruption of the collagen matrix and are typically accompanied by pronounced inflammatory responses and perturbations in the tendon's intrinsic electrical microenvironment. Despite advancements in bridging tendon injuries, few strategies currently target the restoration of the tendon's native electrical microenvironment to facilitate repair. Herein, we fabricated electrospun fibers composed of polycaprolactone (PCL) loaded with dopamine (PDA) modified piezoelectric tetragonal-SrTiO3 (T-SrTiO3) (T-SrTiO3@PCL) for overcoming this problem. The application of PCL based electrospun fibers favours the bridging of tendon injuries by reconstructing the collagen matrix, while the incorporation of piezoelectric T-SrTiO3 simulates the endogenous electrical microenvironment of tendon tissue, with the PDA enhancing the combination between T-SrTiO3 and PCL and thereby further increase piezoelectricity. The therapeutic potential of T-SrTiO3@PCL fibers in tendon repair was evidenced by their ability to modulate the inflammatory response, reduce angiogenesis, and upregulate tendon-specific gene expression, as demonstrated in both in vivo and in vitro experiments. These findings underscore the multifunctional electrospun fibers as a novel strategy for tendon repair, emphasizing the critical structure-function relationship in tendon tissue and recreating a conducive electrical microenvironment for regeneration.
{"title":"Piezoelectrically-enhanced composite membranes mimicking the tendinous electrical microenvironment for advanced tendon repair","authors":"Wenbo Wang , Pei Wang , Qinlin Li , Wufei Dai, Bingcheng Yi, Zhen Gao, Wei Liu, Xiansong Wang","doi":"10.1016/j.nantod.2024.102381","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102381","url":null,"abstract":"<div><p>Tendon injuries, prevalent in clinical settings, predominantly arise from the disruption of the collagen matrix and are typically accompanied by pronounced inflammatory responses and perturbations in the tendon's intrinsic electrical microenvironment. Despite advancements in bridging tendon injuries, few strategies currently target the restoration of the tendon's native electrical microenvironment to facilitate repair. Herein, we fabricated electrospun fibers composed of polycaprolactone (PCL) loaded with dopamine (PDA) modified piezoelectric tetragonal-SrTiO<sub>3</sub> (T-SrTiO<sub>3</sub>) (T-SrTiO<sub>3</sub>@PCL) for overcoming this problem. The application of PCL based electrospun fibers favours the bridging of tendon injuries by reconstructing the collagen matrix, while the incorporation of piezoelectric T-SrTiO<sub>3</sub> simulates the endogenous electrical microenvironment of tendon tissue, with the PDA enhancing the combination between T-SrTiO<sub>3</sub> and PCL and thereby further increase piezoelectricity. The therapeutic potential of T-SrTiO<sub>3</sub>@PCL fibers in tendon repair was evidenced by their ability to modulate the inflammatory response, reduce angiogenesis, and upregulate tendon-specific gene expression, as demonstrated in both <em>in vivo</em> and <em>in vitro</em> experiments. These findings underscore the multifunctional electrospun fibers as a novel strategy for tendon repair, emphasizing the critical structure-function relationship in tendon tissue and recreating a conducive electrical microenvironment for regeneration.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1748013224002378/pdfft?md5=14fba532ffc0ea2ab6e2f15719f752b6&pid=1-s2.0-S1748013224002378-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-28DOI: 10.1016/j.nantod.2024.102379
Swapnil R. Patil , Muhammad Noman , Rakesh Kulkarni , Chandrashekhar S. Patil , Qazi Muhammad Saqib , Mahesh Y. Chougale , Jungmin Kim , Youngbin Ko , Young Pyo Jeon , Tukaram D. Dongale , Jeong Chan Kang , Myung Sook Kim , Yoon-Young Chang , Jinho Bae
The quest for a future with greater environmental sustainability has led to a rising focus on investigating innovative methods for energy production and storage. However, marine invasions have steadily increased over the past two centuries, necessitating innovative approaches for the remediation and preservation of oceanic environments. Especially, Sargassum horneri (S. horneri) is a brown algae that causes massive floating macroalgal blooms along the coasts of East Asia. Given these facts, this paper develops high-performance triboelectric nanogenerator (TENG), and electrode material for both supercapacitor and water-splitting devices based on S. horneri. The TENG device, constructed using S. horneri coastal bio-waste collected from Jeju Island, yields impressive results. The output current, voltage and power generated by the S. horneri-based triboelectric nanogenerator (SH-TENG) is around 47 µA, 775 V, and 2880 µW, respectively. The electrochemical analysis of carbon derived from S. horneri reveals an excellent electrode capacitance of 225 F/g at 2.5 mA. Constructing the symmetric supercapacitor device using S. horneri-derived carbon, which shows excellent energy and power densities around 14.85 Wh/kg and 972.22 W/kg, with remarkable cyclic stability of 81.3 % for 5000 GCD cycles at 7 mA. On the other hand, the developed S. horneri electrode demonstrated much-improved activity towards water splitting application, exhibiting overpotentials of 0.101 V and 0.198 V for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) at an applied current density of 20 mA/cm2, respectively. The fabricated sample also demonstrated the lowest Tafel values towards HER (119 mv/dec) and for OER (109 mv/dec). Finally, the time series analysis (TSA) technique was employed for modeling and prediction of capacity retention of the SH//SH supercapacitor and electrochemical potential (E) of SH/NF║SH/NF cell. In both cases, the mean squared error between experimental and predicted data was very small, suggesting the TSA is a powerful statistical technique to model and predict the vial features of the electrochemical devices. Overall, these results suggest that S. horneri-derived carbon presents a viable alternative in the realm of energy storage and harvesting, promising sustainable technological advancements.
对未来环境可持续性的追求促使人们越来越重视研究能源生产和储存的创新方法。然而,在过去的两个世纪里,海洋生物入侵的数量持续上升,因此有必要采用创新方法来修复和保护海洋环境。特别是马尾藻(Sargassum horneri,S. horneri),它是一种褐藻,在东亚沿海造成大规模的浮游大型藻类水华。鉴于这些事实,本文开发了高性能三电纳米发电机(TENG),以及基于马尾藻的超级电容器和水分离装置的电极材料。利用从济州岛收集的 S. horneri 海岸生物废料制造的 TENG 设备取得了令人瞩目的成果。基于 S. horneri 的三电纳米发电机(SH-TENG)产生的输出电流、电压和功率分别约为 47 µA、775 V 和 2880 µW。从 S. horneri 中提取的碳的电化学分析表明,在 2.5 mA 电流条件下,电极电容高达 225 F/g。利用 S. horneri 衍生碳构建的对称超级电容器装置显示出出色的能量密度和功率密度,分别约为 14.85 Wh/kg 和 972.22 W/kg,在 7 mA 电流条件下循环 5000 GCD 周期的稳定性高达 81.3%。另一方面,所开发的 S. horneri 电极在水分离应用方面的活性大大提高,在 20 mA/cm2 的应用电流密度下,氢进化反应(HER)和氧进化反应(OER)的过电位分别为 0.101 V 和 0.198 V。制备的样品还显示出氢进化反应(119 mv/dec)和氧进化反应(109 mv/dec)的最低塔菲尔值。最后,利用时间序列分析(TSA)技术对 SH//SH 超级电容器的容量保持率和 SH/NF║SH/NF 电池的电化学电位(E)进行了建模和预测。在这两种情况下,实验数据与预测数据之间的均方误差都非常小,这表明 TSA 是一种强大的统计技术,可用于建模和预测电化学装置的瓶体特征。总之,这些结果表明,S. horneri-derived 碳在能量存储和收集领域提供了一种可行的替代方法,有望实现可持续的技术进步。
{"title":"Unveiling the marine Sargassum horneri material for energy and active sensor devices: Towards multitasking approaches","authors":"Swapnil R. Patil , Muhammad Noman , Rakesh Kulkarni , Chandrashekhar S. Patil , Qazi Muhammad Saqib , Mahesh Y. Chougale , Jungmin Kim , Youngbin Ko , Young Pyo Jeon , Tukaram D. Dongale , Jeong Chan Kang , Myung Sook Kim , Yoon-Young Chang , Jinho Bae","doi":"10.1016/j.nantod.2024.102379","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102379","url":null,"abstract":"<div><p>The quest for a future with greater environmental sustainability has led to a rising focus on investigating innovative methods for energy production and storage. However, marine invasions have steadily increased over the past two centuries, necessitating innovative approaches for the remediation and preservation of oceanic environments. Especially, <em>Sargassum horneri</em> (<em>S. horneri</em>) is a brown algae that causes massive floating macroalgal blooms along the coasts of East Asia. Given these facts, this paper develops high-performance triboelectric nanogenerator (TENG), and electrode material for both supercapacitor and water-splitting devices based on <em>S. horneri.</em> The TENG device, constructed using <em>S. horneri</em> coastal bio-waste collected from Jeju Island, yields impressive results. The output current, voltage and power generated by the <em>S. horneri</em>-based triboelectric nanogenerator (SH-TENG) is around 47 µA, 775 V, and 2880 µW, respectively. The electrochemical analysis of carbon derived from <em>S. horneri</em> reveals an excellent electrode capacitance of 225 F/g at 2.5 mA. Constructing the symmetric supercapacitor device using <em>S. horneri</em>-derived carbon, which shows excellent energy and power densities around 14.85 Wh/kg and 972.22 W/kg, with remarkable cyclic stability of 81.3 % for 5000 GCD cycles at 7 mA. On the other hand, the developed <em>S. horneri</em> electrode demonstrated much-improved activity towards water splitting application, exhibiting overpotentials of 0.101 V and 0.198 V for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) at an applied current density of 20 mA/cm<sup>2</sup>, respectively. The fabricated sample also demonstrated the lowest Tafel values towards HER (119 mv/dec) and for OER (109 mv/dec). Finally, the time series analysis (TSA) technique was employed for modeling and prediction of capacity retention of the SH//SH supercapacitor and electrochemical potential (E) of SH/NF║SH/NF cell. In both cases, the mean squared error between experimental and predicted data was very small, suggesting the TSA is a powerful statistical technique to model and predict the vial features of the electrochemical devices. Overall, these results suggest that <em>S. horneri</em>-derived carbon presents a viable alternative in the realm of energy storage and harvesting, promising sustainable technological advancements.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-27DOI: 10.1016/j.nantod.2024.102367
Yuxuan He , Zhiguang Guo
In recent years, the problem of oil pollution represented by industrial oily waste occurs frequently, and the general hydrophilic filtration materials are facing the problems of clogging and poor hydrophilicity, so the hydrophilic hydrogel materials have received some attention, but the related research can’t balance the filtration materials related to the needs of high efficiency, rapidity and stability. In recent years, research on physically cross-linked hydrogels has been developed. We designed a hydrogel made of natural polymers and modified materials including cotton cloth and copper foam by coating or dip coating, and prepared physically crosslinked hydrogel-modified filtration materials, in which the pore size of 10 μm and a superhydrophilic/underwater superoleophilic wettability with an oil contact angle of more than 150° underwater can realize a water flux of more than 106 L·m−2·h−1 and an oil-water flux of more than 99 % efficiency. The oil-water separation efficiency higher than 99 %. Through the action of its ionic electrolyte, it can decompose emulsions containing different surfactants with an efficiency of more than 99 %, and it still possesses high hydrophilicity and separation efficiency even when immersed in pH=1 acid solution for 1 h, and it still possesses high water flux and separation efficiency even when abraded more than 100 times. The materials used are all non-toxic and are not harmful to the environment after segregation. The physically cross-linked hydrogel prepared in this experiment provides a method for realizing oily wastewater purification without secondary pollution, with high efficiency, rapidity and stability, and has a high potential for further development.
{"title":"Natural polymers-based separation membrane for high-efficient separation of oil water mixture","authors":"Yuxuan He , Zhiguang Guo","doi":"10.1016/j.nantod.2024.102367","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102367","url":null,"abstract":"<div><p>In recent years, the problem of oil pollution represented by industrial oily waste occurs frequently, and the general hydrophilic filtration materials are facing the problems of clogging and poor hydrophilicity, so the hydrophilic hydrogel materials have received some attention, but the related research can’t balance the filtration materials related to the needs of high efficiency, rapidity and stability. In recent years, research on physically cross-linked hydrogels has been developed. We designed a hydrogel made of natural polymers and modified materials including cotton cloth and copper foam by coating or dip coating, and prepared physically crosslinked hydrogel-modified filtration materials, in which the pore size of 10 μm and a superhydrophilic/underwater superoleophilic wettability with an oil contact angle of more than 150° underwater can realize a water flux of more than 10<sup>6</sup> L·m<sup>−2</sup>·h<sup>−1</sup> and an oil-water flux of more than 99 % efficiency. The oil-water separation efficiency higher than 99 %. Through the action of its ionic electrolyte, it can decompose emulsions containing different surfactants with an efficiency of more than 99 %, and it still possesses high hydrophilicity and separation efficiency even when immersed in pH=1 acid solution for 1 h, and it still possesses high water flux and separation efficiency even when abraded more than 100 times. The materials used are all non-toxic and are not harmful to the environment after segregation. The physically cross-linked hydrogel prepared in this experiment provides a method for realizing oily wastewater purification without secondary pollution, with high efficiency, rapidity and stability, and has a high potential for further development.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-27DOI: 10.1016/j.nantod.2024.102382
Chuan Yang , Hongyan Wang , Guangdong Zhou , Sida Qin , Wentao Hou , Shouhui Zhu , Yong Zhao , Bai Sun
The negative differential resistance (NDR) effect has been widely applied in logic circuits, wireless communications, and neural networks, but the study for the coexistence of NDR and resistance switching (RS) behaviors is still in the initial stage. In this work, a memristive device with an Ag/ZnOx/TiOy/indium tin oxide (ITO) structure was fabricated, and the device exhibits coexistence of RS and NDR behaviors with the change of applied voltages at air environment. Further, the stable and controllable coexistence of RS and NDR behaviors can be achieved in the memristive device under extreme environments. In addition, the multifunctional applications of the as-prepared memristor based on the coexistence of RS and NDR behaviors in logic operation and somatosensory temperature sensing were also demonstrated. Finally, based on the in-depth analysis of the experimental data and the energy band theory, the physical models of water molecule (H2O) decomposition, oxygen vacancy (Vo2+), Ag ions (Ag+), and hydroxide ions (OH–) migration were proposed, which reasonably explained the working mechanism of the coexistence of RS and NDR behaviors. Therefore, this work proves that the coexistence behavior of NDR and RS behaviors controlled by multiple factors in memristor has great application prospects for logic operation and somatosensory temperature sensing.
{"title":"A multifunctional memristor with coexistence of NDR and RS behaviors for logic operation and somatosensory temperature sensing applications","authors":"Chuan Yang , Hongyan Wang , Guangdong Zhou , Sida Qin , Wentao Hou , Shouhui Zhu , Yong Zhao , Bai Sun","doi":"10.1016/j.nantod.2024.102382","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102382","url":null,"abstract":"<div><p>The negative differential resistance (NDR) effect has been widely applied in logic circuits, wireless communications, and neural networks, but the study for the coexistence of NDR and resistance switching (RS) behaviors is still in the initial stage. In this work, a memristive device with an Ag/ZnO<sub>x</sub>/TiO<sub>y</sub>/indium tin oxide (ITO) structure was fabricated, and the device exhibits coexistence of RS and NDR behaviors with the change of applied voltages at air environment. Further, the stable and controllable coexistence of RS and NDR behaviors can be achieved in the memristive device under extreme environments. In addition, the multifunctional applications of the as-prepared memristor based on the coexistence of RS and NDR behaviors in logic operation and somatosensory temperature sensing were also demonstrated. Finally, based on the in-depth analysis of the experimental data and the energy band theory, the physical models of water molecule (H<sub>2</sub>O) decomposition, oxygen vacancy (<em>V</em><sub>o</sub><sup>2+</sup>), Ag ions (Ag<sup>+</sup>), and hydroxide ions (OH<sup>–</sup>) migration were proposed, which reasonably explained the working mechanism of the coexistence of RS and NDR behaviors. Therefore, this work proves that the coexistence behavior of NDR and RS behaviors controlled by multiple factors in memristor has great application prospects for logic operation and somatosensory temperature sensing.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-26DOI: 10.1016/j.nantod.2024.102378
Yi Sun , Yaqi Jiang , Haojie Wei , Ziqi Zhang , Samina Irshad , XingXin Liu , Yu Xie , Yukui Rui , Peng Zhang
As climate change accelerates, urgent action to mitigate greenhouse gases (GHGs) emissions is imperative. Nanotechnology, with its unique nanoscale capabilities, offers a promising solution. This review explores nanotechnology's multifaceted applications and implications in GHGs reduction. The introduction underlines the increasing threat of climate change and presents nanotechnology as a transformative tool to combat this global issue. The review includes nanotechnology's diverse roles across different sectors, particularly showcasing its potential to revolutionize emission mitigation strategies. Specific focus is given to key areas where nanotechnology has a significant impact. The discussion covers nanomaterials' role in carbon capture and storage (CCS), highlighting their ability to adsorb CO2 from industrial processes and detailing advanced separation techniques. Nanocatalysts are spotlighted for catalytic conversion, driving reactions that transform GHGs into valuable products. The review extends its focus to renewable energy, demonstrating nanotechnology's potential to enhance solar cells, fuel cells, and energy storage systems. Furthermore, nanotechnology's contributions to GHGs emission from agriculture are explored, explaining how nanofertilizers, nanopesticides, and soil management practices minimize emissions and support sustainable land use. Challenges and prospects are discussed, including nanomaterial toxicity, scalability, and ethical considerations. Regulatory frameworks and stakeholder engagement are explored to address nanotechnology's evolving role in GHGs emission mitigation. The review highlights nanotechnology's potential as a cross-disciplinary solution, driving innovation toward environmental sustainability.
{"title":"Nano-enabled strategies for greenhouse gases emission mitigation: a comprehensive review","authors":"Yi Sun , Yaqi Jiang , Haojie Wei , Ziqi Zhang , Samina Irshad , XingXin Liu , Yu Xie , Yukui Rui , Peng Zhang","doi":"10.1016/j.nantod.2024.102378","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102378","url":null,"abstract":"<div><p>As climate change accelerates, urgent action to mitigate greenhouse gases (GHGs) emissions is imperative. Nanotechnology, with its unique nanoscale capabilities, offers a promising solution. This review explores nanotechnology's multifaceted applications and implications in GHGs reduction. The introduction underlines the increasing threat of climate change and presents nanotechnology as a transformative tool to combat this global issue. The review includes nanotechnology's diverse roles across different sectors, particularly showcasing its potential to revolutionize emission mitigation strategies. Specific focus is given to key areas where nanotechnology has a significant impact. The discussion covers nanomaterials' role in carbon capture and storage (CCS), highlighting their ability to adsorb CO<sub>2</sub> from industrial processes and detailing advanced separation techniques. Nanocatalysts are spotlighted for catalytic conversion, driving reactions that transform GHGs into valuable products. The review extends its focus to renewable energy, demonstrating nanotechnology's potential to enhance solar cells, fuel cells, and energy storage systems. Furthermore, nanotechnology's contributions to GHGs emission from agriculture are explored, explaining how nanofertilizers, nanopesticides, and soil management practices minimize emissions and support sustainable land use. Challenges and prospects are discussed, including nanomaterial toxicity, scalability, and ethical considerations. Regulatory frameworks and stakeholder engagement are explored to address nanotechnology's evolving role in GHGs emission mitigation. The review highlights nanotechnology's potential as a cross-disciplinary solution, driving innovation toward environmental sustainability.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25DOI: 10.1016/j.nantod.2024.102366
Jaekak Yoo , Youngwoo Cho , Dong Hyeon Kim , Jaeseok Kim , Tae Geol Lee , Seung Mi Lee , Jaegul Choo , Mun Seok Jeong
This paper evaluated the degree of reduction in graphene oxide, leveraging deep learning and machine learning models on over 15,000 Raman scattering spectra along with validation using density functional theory calculations. We addressed the limitations of previous studies, such as the consideration of an insufficient number of spectra as well as the lack of a comprehensive analysis of the contribution of individual Raman modes, by introducing machine learning and deep learning. Moreover, our models succeeded in predicting the carbon-to-oxygen ratio and classifying the reduction temperatures using the Raman scattering spectra as input. Employing the partial dependence plot and the feature importance, we interpreted the models and obtained consistent results on the significance of D* mode in graphene oxide. The intensity of the D* mode stands out by not only displaying the highest feature importance value for the reduction temperatures but also by correlating proportionally with the widest range of carbon-to-oxygen ratios among the various Raman modes in graphene oxide. Finally, we validated our findings through quantum mechanical calculations and confirmed the significance of the D* mode. Our study presents a comprehensive insight into the role of Raman modes in the degree of reduction as well as a precise methodology for evaluating the carbon-to-oxygen ratio of graphene oxide, a step towards its further industrial applications.
{"title":"Unraveling the role of Raman modes in evaluating the degree of reduction in graphene oxide via explainable artificial intelligence","authors":"Jaekak Yoo , Youngwoo Cho , Dong Hyeon Kim , Jaeseok Kim , Tae Geol Lee , Seung Mi Lee , Jaegul Choo , Mun Seok Jeong","doi":"10.1016/j.nantod.2024.102366","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102366","url":null,"abstract":"<div><p>This paper evaluated the degree of reduction in graphene oxide, leveraging deep learning and machine learning models on over 15,000 Raman scattering spectra along with validation using density functional theory calculations. We addressed the limitations of previous studies, such as the consideration of an insufficient number of spectra as well as the lack of a comprehensive analysis of the contribution of individual Raman modes, by introducing machine learning and deep learning. Moreover, our models succeeded in predicting the carbon-to-oxygen ratio and classifying the reduction temperatures using the Raman scattering spectra as input. Employing the partial dependence plot and the feature importance, we interpreted the models and obtained consistent results on the significance of D* mode in graphene oxide. The intensity of the D* mode stands out by not only displaying the highest feature importance value for the reduction temperatures but also by correlating proportionally with the widest range of carbon-to-oxygen ratios among the various Raman modes in graphene oxide. Finally, we validated our findings through quantum mechanical calculations and confirmed the significance of the D* mode. Our study presents a comprehensive insight into the role of Raman modes in the degree of reduction as well as a precise methodology for evaluating the carbon-to-oxygen ratio of graphene oxide, a step towards its further industrial applications.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.1016/j.nantod.2024.102377
Li Liang , Ning Wang , Xiang Li , Zhuan Zhang , Zhu Zhu , Yan Zhuo , Xiaohe Jiang , Jie Wang , Cong Guo , Shiyan Guo , Pinghong Zhou , Yan Zhu , Yong Gan , Miaorong Yu
Exosomes are nanoscale extracellular vesicles that have become pivotal in advancing targeted drug delivery strategies for cancer therapy. In this study, we conducted a comparative analysis of the intracellular targeting capabilities of differently shaped exosomes, including milk exosome nanorods (MR), ginger exosome nanorods (GR), and cancer cell exosome nanorods (HR), compared to their spherical counterparts. Our observations revealed that exosome nanorods demonstrated effective and sustained targeting of the endoplasmic reticulum (ER) within cancer cells, while exosome nanospheres were captured within lysosomes. Building on this principle, we chose milk-derived exosomes (mExo) for the in vivo research, engineering the surface of MR with folate to enhance their tumor-targeting efficacy. We demonstrated the effective accumulation of these folate-modified MR (FMR) around the ER in cancer cells, as validated in both orthotopic colorectal cancer (CRC) tissues and human CRC biopsy samples. Furthermore, when loaded with curcumin (Cur), the FMR@Cur exhibited remarkable efficacy in suppressing tumors in orthotopic CRC mouse models. This effect is attributed to the targeted delivery of FMR@Cur to the ER, leading to enhanced ER-stress induced apoptosis. Overall, our study underscores the pivotal role of shape engineering in exosome-mediated drug delivery, offering novel insights and paving the way for innovative strategies to enhance the precision of intracellular drug targeting in cancer therapy.
外泌体是一种纳米级细胞外囊泡,在推进癌症治疗的靶向给药策略方面发挥着举足轻重的作用。在这项研究中,我们比较分析了不同形状的外泌体(包括牛奶外泌体纳米棒(MR)、生姜外泌体纳米棒(GR)和癌细胞外泌体纳米棒(HR))与球形外泌体的胞内靶向能力。我们的观察结果表明,外泌体纳米棒能有效、持续地靶向癌细胞内的内质网(ER),而外泌体纳米球则能捕获溶酶体。基于这一原理,我们选择了源于牛奶的外泌体(mExo)进行体内研究,用叶酸对MR表面进行工程处理,以增强其肿瘤靶向功效。我们证明了这些叶酸修饰的MR(FMR)在癌细胞ER周围的有效聚集,这在正位结直肠癌(CRC)组织和人类CRC活检样本中都得到了验证。此外,当载入姜黄素(Cur)时,FMR@Cur 对抑制正位 CRC 小鼠模型中的肿瘤具有显著疗效。这种效果归功于 FMR@Cur 对 ER 的靶向递送,从而增强了 ER 压力诱导的细胞凋亡。总之,我们的研究强调了形状工程在外泌体介导的药物递送中的关键作用,为提高癌症治疗中细胞内药物靶向的精确性提供了新的见解,并为创新策略铺平了道路。
{"title":"Shape Engineering of Exosomes for Endoplasmic Reticulum-Targeted Delivery and Amplified Anticancer Efficacy","authors":"Li Liang , Ning Wang , Xiang Li , Zhuan Zhang , Zhu Zhu , Yan Zhuo , Xiaohe Jiang , Jie Wang , Cong Guo , Shiyan Guo , Pinghong Zhou , Yan Zhu , Yong Gan , Miaorong Yu","doi":"10.1016/j.nantod.2024.102377","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102377","url":null,"abstract":"<div><p>Exosomes are nanoscale extracellular vesicles that have become pivotal in advancing targeted drug delivery strategies for cancer therapy. In this study, we conducted a comparative analysis of the intracellular targeting capabilities of differently shaped exosomes, including milk exosome nanorods (MR), ginger exosome nanorods (GR), and cancer cell exosome nanorods (HR), compared to their spherical counterparts. Our observations revealed that exosome nanorods demonstrated effective and sustained targeting of the endoplasmic reticulum (ER) within cancer cells, while exosome nanospheres were captured within lysosomes. Building on this principle, we chose milk-derived exosomes (mExo) for the <em>in vivo</em> research, engineering the surface of MR with folate to enhance their tumor-targeting efficacy. We demonstrated the effective accumulation of these folate-modified MR (FMR) around the ER in cancer cells, as validated in both orthotopic colorectal cancer (CRC) tissues and human CRC biopsy samples. Furthermore, when loaded with curcumin (Cur), the FMR@Cur exhibited remarkable efficacy in suppressing tumors in orthotopic CRC mouse models. This effect is attributed to the targeted delivery of FMR@Cur to the ER, leading to enhanced ER-stress induced apoptosis. Overall, our study underscores the pivotal role of shape engineering in exosome-mediated drug delivery, offering novel insights and paving the way for innovative strategies to enhance the precision of intracellular drug targeting in cancer therapy.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.1016/j.nantod.2024.102365
Jenny Schunke , Natkritta Hüppe , Nicole Mangazeev , Kai R. Speth , Katja Rohde , Felicia Schön , Vanessa Bolduan , Paul Schneider , Tanja Klaus , Michael Kuske , Stephan Grabbe , Katharina Landfester , Volker Mailänder , Michael Fichter
Insufficient efficacy of tumor vaccines still represents a major challenge due to poor adjuvant potency. Combining antigen and adjuvants of different classes bears the potential to induce a broad spectrum of anti-tumor immune responses. Here we demonstrate a novel nanocarrier (NC)-based vaccine combining the type I interferon-triggering STING agonist diamidobenzimidazole (diABZI) compound 3 and the well-established TLR7/8 agonist resiquimod (R848). Encapsulation of both adjuvants into polymeric nanocapsules enables the simultaneous transport of immunostimulatory molecules with tumor antigens. Thereby achieved co-delivery further improved DC stimulation and subsequent anti-tumor immune responses.
Combined encapsulation of R848 and diABZI enhanced DC activation and induced stronger antigen-specific T cell responses compared to the single adjuvant NC treatment or using soluble forms of antigens and adjuvants in vitro and in vivo. This was determined by the vigorous expression of CD80, CD83, and CD86. Furthermore, the dual adjuvant therapy initiated the highest secretion levels of different pro-inflammatory cytokines and chemokines.
Moreover, a substantial antigen-specific T cell proliferation led to robust tumor remission in a murine B16 melanoma model. Subcutaneous administration of R848/diABZI-loaded NCs induced enhanced infiltration of CD4+ and CD8+ T cells as well as neutrophils in tumor-draining lymph nodes (LN) and tumor tissue. Encapsulating the melanoma-specific antigenic peptide of TRP2 into the adjuvant-loaded NCs reduced the growth of B16 melanoma and prolonged the overall survival. The herein presented novel anti-tumor vaccination strategy avoids the use of structural compounds, increases the antigen load of dendritic cells, uses a fixed combination of antigen and two potent adjuvants and bears the potential to induce vigorous antigen-specific anti-cancer immunity.
由于佐剂效力差,肿瘤疫苗疗效不佳仍是一大挑战。结合不同类别的抗原和佐剂有可能诱导广泛的抗肿瘤免疫反应。在这里,我们展示了一种基于纳米载体(NC)的新型疫苗,它结合了能触发I型干扰素的STING激动剂二脒苯并咪唑(diABZI)化合物3和成熟的TLR7/8激动剂瑞舒吉莫德(R848)。将这两种佐剂封装到聚合物纳米胶囊中,可以同时运输免疫刺激分子和肿瘤抗原。与单一佐剂 NC 处理或在体外和体内使用可溶性形式的抗原和佐剂相比,R848 和 diABZI 的联合封装可增强 DC 的活化并诱导更强的抗原特异性 T 细胞反应。这可以通过 CD80、CD83 和 CD86 的强烈表达来确定。此外,在小鼠 B16 黑色素瘤模型中,抗原特异性 T 细胞的大量增殖导致了肿瘤的强效缓解。皮下注射负载 R848/diABZI 的 NCs 可增强 CD4+ 和 CD8+ T 细胞以及中性粒细胞在肿瘤引流淋巴结(LN)和肿瘤组织中的浸润。将黑色素瘤特异性抗原肽TRP2封装到佐剂载入的NCs中,可减少B16黑色素瘤的生长并延长总生存期。本文介绍的新型抗肿瘤疫苗接种策略避免了结构化合物的使用,增加了树突状细胞的抗原负荷,使用了抗原和两种强效佐剂的固定组合,具有诱导抗原特异性抗癌免疫的潜力。
{"title":"Co-delivery of STING and TLR7/8 agonists in antigen-based nanocapsules to dendritic cells enhances CD8+ T cell-mediated melanoma remission","authors":"Jenny Schunke , Natkritta Hüppe , Nicole Mangazeev , Kai R. Speth , Katja Rohde , Felicia Schön , Vanessa Bolduan , Paul Schneider , Tanja Klaus , Michael Kuske , Stephan Grabbe , Katharina Landfester , Volker Mailänder , Michael Fichter","doi":"10.1016/j.nantod.2024.102365","DOIUrl":"https://doi.org/10.1016/j.nantod.2024.102365","url":null,"abstract":"<div><p>Insufficient efficacy of tumor vaccines still represents a major challenge due to poor adjuvant potency. Combining antigen and adjuvants of different classes bears the potential to induce a broad spectrum of anti-tumor immune responses. Here we demonstrate a novel nanocarrier (NC)-based vaccine combining the type I interferon-triggering STING agonist diamidobenzimidazole (diABZI) compound 3 and the well-established TLR7/8 agonist resiquimod (R848). Encapsulation of both adjuvants into polymeric nanocapsules enables the simultaneous transport of immunostimulatory molecules with tumor antigens. Thereby achieved co-delivery further improved DC stimulation and subsequent anti-tumor immune responses.</p><p>Combined encapsulation of R848 and diABZI enhanced DC activation and induced stronger antigen-specific T cell responses compared to the single adjuvant NC treatment or using soluble forms of antigens and adjuvants <em>in vitro</em> and <em>in vivo</em>. This was determined by the vigorous expression of CD80, CD83, and CD86. Furthermore, the dual adjuvant therapy initiated the highest secretion levels of different pro-inflammatory cytokines and chemokines.</p><p>Moreover, a substantial antigen-specific T cell proliferation led to robust tumor remission in a murine B16 melanoma model. Subcutaneous administration of R848/diABZI-loaded NCs induced enhanced infiltration of CD4<sup>+</sup> and CD8<sup>+</sup> T cells as well as neutrophils in tumor-draining lymph nodes (LN) and tumor tissue. Encapsulating the melanoma-specific antigenic peptide of TRP2 into the adjuvant-loaded NCs reduced the growth of B16 melanoma and prolonged the overall survival. The herein presented novel anti-tumor vaccination strategy avoids the use of structural compounds, increases the antigen load of dendritic cells, uses a fixed combination of antigen and two potent adjuvants and bears the potential to induce vigorous antigen-specific anti-cancer immunity.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}