Abnormal resting-state functional connectivity of the right anterior cingulate cortex in chronic ketamine users and its correlation with cognitive impairments

IF 3.8 4区医学 Q1 PSYCHIATRY Asian journal of psychiatry Pub Date : 2024-09-14 DOI:10.1016/j.ajp.2024.104199

Jun Zhong , Fengchun Wu , Huawang Wu , Hongbo He , Zhaohua Zhang , Ni Fan

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Abstract

Background

Chronic ketamine use leads to cognitive impairments, however, the neural mechanisms underpinning these impairments are still unclear.

Aims

Many studies showed Anterior cingulate cortex (ACC)is strongly involved in cognition and drug addiction, as supported by our previous studies. The objective of this study was to assess the variations in resting-state functional connectivity (FC) changes in the right anterior cingulate cortex (ACC) of chronic ketamine users (CKUs) and their relationship with cognitive performance.

Methods

The study enrolled 28 chronic ketamine users (CKUs) and 30 healthy controls (HCs). Resting-state functional magnetic resonance imaging (fMRI) data were gathered from both groups. Cognitive functions were evaluated using the MATRICS Consensus Cognitive Battery (MCCB).

Results

CKUs demonstrated significantly poorer cognitive performance than HCs in various cognitive domains, including Visual Learning, Speed of Processing, Working Memory, and the composite score of MCCB. Group-level comparisons revealed that CKUs exhibited enhanced functional connectivity between the right ACC and the right postcentral gyrus (PCG) compared to HCs. There was a positive relationship between the connectivity of right ACC-PCG and reasoning and problem-solving score, but there was no significant association with the characteristics of ketamine use.

Conclusion

CKUs showed enhanced connectivity between the right ACC and the right PCG. This enhanced functional connectivity may indicate functional compensation for cognitive deficits in CKUs, especially for reasoning and problem-solving impairments in CKUs.

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慢性氯胺酮使用者右前扣带回皮层异常的静息态功能连接及其与认知障碍的相关性

研究目的：许多研究表明，前扣带皮层（ACC）与认知和药物成瘾密切相关。本研究旨在评估慢性氯胺酮使用者（CKUs）右侧前扣带皮层（ACC）的静息态功能连接（FC）变化及其与认知表现的关系。研究收集了两组人的静息态功能磁共振成像（fMRI）数据。结果慢性氯胺酮使用者在视觉学习、处理速度、工作记忆和MCCB综合评分等多个认知领域的认知表现均显著低于健康对照者。组间比较显示，CKUs与HCs相比，右侧ACC和右侧中央后回（PCG）之间的功能连接性增强。右侧ACC-PCG的连通性与推理和问题解决得分之间存在正相关，但与氯胺酮使用特征无显著关联。这种功能连接的增强可能表明了对氯胺酮依赖者认知缺陷的功能补偿，尤其是对氯胺酮依赖者推理和问题解决能力缺陷的补偿。

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来源期刊

Asian journal of psychiatry Medicine-Psychiatry and Mental Health

CiteScore

12.70

自引率

5.30%

发文量

297

审稿时长

35 days

期刊介绍： The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.