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The effectiveness of repetitive transcranial magnetic stimulation (rTMS) in patients with catatonia associated with another mental disorder: A systematic review. 重复经颅磁刺激(rTMS)对伴有其他精神障碍的紧张症患者的疗效:系统综述。
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-19 DOI: 10.1016/j.ajp.2024.104311
Sarvenaz Esmaeelzadeh, Razi Mahmood, Altaf Masood

Background: Catatonia is a rare but life-threatening condition characterized by a constellation of psychomotor disturbances. The most widely used treatments of catatonia include benzodiazepines and electroconvulsive therapy. Despite the widespread use of benzodiazepines and the high response rate of catatonia to ECT, there are instances where catatonia does not respond to first-line treatments. This study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in managing catatonia.

Methods: A systematic literature search was conducted on the following databases: Medline, PubMed, Cochrane Library, Embase, PsycINFO and ClinicalTrials.gov for registered but not yet published studies.

Results: Out of 244 initially identified articles, there remained eight case reports and 1 case series eligible after screening. Of the twelve total cases, nine showed clinical improvement. However, there was significant heterogeneity in the complexity of the clinical situation, the severity of clinical features of catatonia, underlying causes, and rTMS treatment protocols between studies.

Conclusion: The results of this study are inconclusive. However, rTMS might be trialed for the management of catatonia when first-line treatment options fail, are unavailable, or need to be used with caution. Our review incorporating the most up to date evidence highlights the need for more extensive, standardized, randomized clinical trials to investigate the efficacy of rTMS for treating catatonia.

背景:紧张症是一种罕见但危及生命的疾病,其特征是一系列精神运动障碍。紧张症最广泛使用的治疗方法包括苯二氮卓类药物和电休克疗法。尽管苯二氮卓类药物被广泛使用,而且紧张性精神障碍对电休克疗法的反应率很高,但有时紧张性精神障碍对一线治疗无效。本研究旨在评估重复经颅磁刺激(rTMS)治疗紧张症的疗效:在以下数据库中进行了系统的文献检索:方法:在以下数据库中进行了系统的文献检索:Medline、PubMed、Cochrane Library、Embase、PsycINFO 和 ClinicalTrials.gov,检索已注册但尚未发表的研究:在 244 篇初步确定的文章中,经过筛选,仍有 8 篇病例报告和 1 篇系列病例符合条件。在总共 12 个病例中,9 个病例的临床症状有所改善。然而,不同研究在临床情况的复杂程度、紧张症临床特征的严重程度、潜在病因和经颅磁刺激治疗方案等方面存在明显的异质性:结论:这项研究的结果尚无定论。然而,当一线治疗方案失败、无法使用或需要慎重使用时,经颅磁刺激疗法可试用于紧张症的治疗。我们结合最新证据进行的综述强调,有必要进行更广泛、标准化、随机化的临床试验,以研究经颅磁刺激治疗紧张症的疗效。
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引用次数: 0
Enduring conflict: The effects of war trauma on the well-being of Palestinian children. 持久的冲突:战争创伤对巴勒斯坦儿童福祉的影响。
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-08 DOI: 10.1016/j.ajp.2024.104304
Amani N Alansari
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引用次数: 0
Altered resting-state brain activity of the superior parietal cortex and striatum in major depressive disorder and schizophrenia 重度抑郁障碍和精神分裂症患者的上顶叶皮层和纹状体静息态大脑活动改变。
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-04 DOI: 10.1016/j.ajp.2024.104303
Cheng Chen , Baoli Zhang , Xucong Qin , Huan Huang , Bei Rong , Huiling Wang , Liang Zhang , Wei Yuan

Background

Resting-state functional magnetic resonance imaging (fMRI) studies have shown altered brain activity in major depressive disorder (MDD) and schizophrenia (SZ). Despite differing diagnoses, SZ and MDD share similar features. However, functional brain activity similarities and differences between SZ and MDD remain unclear.

Methods

Participants with MDD, SZ, and normal controls (n=36 each) underwent resting-state fMRI scans. Amplitude of low-frequency fluctuations (ALFF) was used to analyze the preprocessed rs-fMRI data. One-way ANOVAs and post hoc analyses compared ALFF values in different brain regions. Pearson correlation analysis examined associations with clinical symptoms.

Results

Comparison among the three groups revealed significant differences in ALFF values within the left superior parietal cortex (L-SPC) and bilateral striatum. Through pairwise comparisons, patients with SZ but not patients with MDD were found to exhibit increased striatum ALFF values relative to NC individuals, but decreased in MDD. Meanwhile, L-SPC ALFF values were significantly increased in patients with SZ relative to both normal control individuals and patients with MDD, while no differences in these values were observed between the normal control and MDD groups. The Pearson correlation analyses showed significant positive correlations between ALFF in the striatum and PANSS positive score, but no significant correlation with other symptom severity in SZ and MDD.

Conclusion

These findings support the hypothesis of alterations in brain functional activity as a fundamental component of the pathogenesis of MDD and SZ. The observed differences in functional brain activity in the superior parietal cortex and striatum between MDD and SZ provide a neuroimaging basis that can contribute to the differential diagnosis of these debilitating conditions.
背景:静息态功能磁共振成像(fMRI)研究显示,重度抑郁症(MDD)和精神分裂症(SZ)患者的大脑活动发生了改变。尽管诊断方法不同,但 SZ 和 MDD 具有相似的特征。然而,SZ 和 MDD 之间大脑功能活动的异同仍不清楚:方法:对患有 MDD、SZ 和正常对照组的参与者(各 36 人)进行静息态 fMRI 扫描。低频波动幅度(ALFF)用于分析预处理后的rs-fMRI数据。单因素方差分析和事后分析比较了不同脑区的 ALFF 值。皮尔逊相关分析检验了与临床症状的关联:三组患者的比较结果显示,左上顶叶皮层(L-SPC)和双侧纹状体的 ALFF 值存在显著差异。通过配对比较发现,相对于NC患者,SZ患者(而非MDD患者)的纹状体ALFF值升高,但MDD患者的ALFF值降低。同时,与正常对照组和 MDD 患者相比,SZ 患者的 L-SPC ALFF 值明显升高,而正常对照组和 MDD 组之间的 ALFF 值没有差异。皮尔逊相关分析表明,纹状体中的 ALFF 与 PANSS 阳性评分呈显著正相关,但与 SZ 和 MDD 的其他症状严重程度无显著相关:这些研究结果支持大脑功能活动的改变是 MDD 和 SZ 发病机制的基本组成部分这一假设。在顶叶上皮层和纹状体中观察到的 MDD 和 SZ 的大脑功能活动差异提供了一个神经影像学基础,有助于这些衰弱性疾病的鉴别诊断。
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引用次数: 0
Modulating neuroplasticity through synergistic ketamine and accelerated sequential theta burst stimulation (TBS) for treatment-resistant depression (TRD) – A case report 通过氯胺酮和加速序列θ爆发刺激(TBS)的协同作用调节神经可塑性,治疗耐药抑郁症(TRD)--病例报告
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-04 DOI: 10.1016/j.ajp.2024.104302
Veena Ramesh, Varsha Shamanna, Harsh Pathak, Swarna Buddha Nayok, Anushree Bose, Vanteemar S. Sreeraj, Ganesan Venkatasubramanian
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引用次数: 0
Severe suicide attempts, day of the week, and holidays in South Korea: A nationwide case time series study 韩国的严重自杀企图、星期和节假日:全国病例时间序列研究。
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-31 DOI: 10.1016/j.ajp.2024.104299
Harin Min , Jiwoo Park , Hyewon Yoon, Jieun Oh, Sojin Ahn, Cinoo Kang, Whanhee Lee
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引用次数: 0
Reliability and validity study of the Turkish version of the Schizophrenia Cognition Rating Scale (SCoRS-TR) 土耳其版精神分裂症认知评定量表(SCoRS-TR)的可靠性和有效性研究。
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-31 DOI: 10.1016/j.ajp.2024.104301
Nedim Özak , Emine Ilgın Hoşgelen , Berna Binnur Akdede , Köksal Alptekin

Background

Schizophrenia is characterized by significant dysfunction in cognitive domains. Despite its crucial role in prognosis, evaluating neurocognitive impairments is challenging in outpatient settings because of the time-consuming nature of neurocognitive assessments. SCoRS “Schizophrenia Cognition Rating Scale” is a scale that provides brief cognitive evaluation. This study aimed to establish the validity and reliability of the Turkish version of the “Schizophrenia Cognition Rating Scale” (SCoRS-TR) in patients with schizophrenia and examine the correlation between SCoRS and cognitive tests.

Methods

Data were collected from 130 patients with schizophrenia who met the DSM-5 criteria and 40 healthy controls. SCoRS rating, Positive and Negative Syndrome Scale (PANSS), and a neurocognitive test battery were administered.

Results

Findings indicated that SCoRS-TR is a reliable and valid scale for the Turkish population. The scale demonstrated strong internal consistency, with Cronbach's alpha values ranging from 0.937 to 0.940. High interrater reliability (ranging from 0.90 to 0.98) and test-retest reliability (ranging from 0.976 to 0.990) were observed. SCoRS-TR significantly discriminated patients from healthy controls (p<0.001). SCoRS-TR exhibited significant correlations to neurocognitive tests.

Discussion

Results indicated that SCoRS-TR had significant reliability and validity scores that may be useful for evaluating daily life functioning related to cognitive dysfunction in patients with schizophrenia. This approach may be useful for neurocognitive evaluation and monitoring in clinical follow-up and outpatient settings.
背景:精神分裂症的特点是认知功能严重障碍。尽管神经认知障碍在预后中起着至关重要的作用,但由于神经认知评估耗时较长,因此在门诊环境中评估神经认知障碍具有挑战性。SCoRS "精神分裂症认知评定量表 "是一种提供简短认知评估的量表。本研究旨在确定土耳其版 "精神分裂症认知评定量表"(SCoRS-TR)在精神分裂症患者中的有效性和可靠性,并研究 SCoRS 与认知测试之间的相关性:收集了 130 名符合 DSM-5 标准的精神分裂症患者和 40 名健康对照者的数据。方法:收集 130 名符合 DSM-5 标准的精神分裂症患者和 40 名健康对照者的数据,并进行 SCoRS 评分、阳性与阴性综合征量表(PANSS)和神经认知测试:结果:研究结果表明,SCoRS-TR 对土耳其人来说是一个可靠、有效的量表。该量表具有很强的内部一致性,Cronbach's alpha 值在 0.937 至 0.940 之间。研究人员之间的信度(从 0.90 到 0.98)和测试再测信度(从 0.976 到 0.990)都很高。SCoRS-TR 能明显区分患者和健康对照组(p 讨论:结果表明,SCoRS-TR 具有显著的信度和效度,可用于评估精神分裂症患者与认知功能障碍相关的日常生活功能。这种方法可用于临床随访和门诊环境中的神经认知评估和监测。
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引用次数: 0
Closure risk of general hospital psychiatric units: Impact of financial pressures and psychiatrist staffing challenges 综合医院精神科关闭的风险:财务压力和精神科医生人员配备挑战的影响
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-29 DOI: 10.1016/j.ajp.2024.104300
Michitaka Funayama, Shigeki Sato, Hiraki Koishikawa, Naoko Satake, On Kato, Masayuki Noguchi, Tomoji Takata, Yusuke Hasegawa, Hisashi Wada, Takaki Akahane, Naohisa Tsujino, Katsuji Nishimura
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引用次数: 0
Effectiveness of a package of community-based mental healthcare services to address perinatal mental disorders in Bangladesh: A cluster-randomized controlled trial 以社区为基础的一揽子精神保健服务对解决孟加拉国围产期精神障碍的有效性:分组随机对照试验
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-25 DOI: 10.1016/j.ajp.2024.104290
Goutam Kumar Dutta , Helal Uddin Ahmed , Md. Quiume Talukder , Dipika Shankar Bhattacharyya , M. Shamim Reza , Md. Musfikur Rahman , Ratna Majumdar , Fahmida Tofail , Henry B. Perry , Taposh Kumar Biswas

Background

Perinatal mental disorders of women have an impact on their pregnancy and their child’s brain development across low and middle-income countries. However, to address this issue, there are no specific guidelines for community-level service providers in Bangladesh. Therefore, we aimed to develop a community-based mental healthcare (CBMHC) service package and test its effectiveness in reducing depression, anxiety, and stress among mothers during the perinatal period.

Methods

A cluster-randomized controlled trial (cRCT) was applied to test the CBMHC package in 2017 and 2018. It was provided to one group of mothers along with routine maternal care while another group received only routine maternal care. Paired sample t-test was applied to assess mean changes at baseline and endline in the Depression, Anxiety, and Stress Scales-21 (DASS-21) and EuroQol-5 Dimension and 3 Level (EQ5D3L) scales. A linear mixed-effects model was used to assess the relationship between the DASS-21 score and EQ5D3L.

Results

1215 participants were enrolled, including 605 in the intervention group and 610 in the control group. Measures of depression, anxiety, and stress were significantly decreased in both groups. Reduction in the levels of stress, as measured by changes in the stress score, were significantly greater in the intervention than in the control group (diff: 1.2, 95 % CI: 0.1, 2.2). The EQ5D3L index improved significantly, 0.02 units more at endline in the intervention group than in the control group (diff: 0.02, 95 % CI: 0.007, 0.03). The levels of mobility, usual activities, pain or discomfort, depression, and anxiety improved by 1.4 %, 7.6 %, 4.4 %, 2.6 %, and 0.4 % more, respectively, in the intervention group compared to the control groups. These improvements were statistically significant. The DASS-21 score was negatively and significantly correlated with both the EQ-5D3L index and the Visual Analogue Scale (VAS) score for the intervention group as well as for the usual care group, indicating that EQ5D3L improved when common mental disorders decreased.

Conclusion

Although the improvements were modest, a CBMHC service package was effective in reducing perinatal levels of stress among Bangladeshi rural women.

Trial Registration

ClinicalTrials.gov ID: NCT03678415
背景在中低收入国家,妇女的产前精神障碍会影响她们的妊娠和孩子的大脑发育。然而,为了解决这一问题,孟加拉国还没有针对社区一级服务提供者的具体指导原则。因此,我们旨在开发基于社区的心理保健(CBMHC)服务包,并测试其在减少围产期母亲抑郁、焦虑和压力方面的有效性。方法在 2017 年和 2018 年采用分组随机对照试验(cRCT)来测试 CBMHC 服务包。一组母亲在接受常规孕产妇护理的同时还接受了该套餐,而另一组母亲仅接受常规孕产妇护理。采用配对样本t检验来评估抑郁、焦虑和压力量表-21(DASS-21)和EuroQol-5 Dimension and 3 Level(EQ5D3L)量表在基线和终点的平均变化。采用线性混合效应模型评估 DASS-21 评分与 EQ5D3L 之间的关系。结果1215 名参与者参加了干预组,其中 605 人,对照组 610 人。干预组和对照组的抑郁、焦虑和压力测量值均显著下降。以压力评分的变化来衡量,干预组压力水平的降低幅度明显高于对照组(差值:1.2,95 % CI:0.1,2.2)。干预组的 EQ5D3L 指数明显改善,在终点线时比对照组多 0.02 个单位(差异:0.02,95 % CI:0.007,0.03)。与对照组相比,干预组的行动能力、日常活动、疼痛或不适、抑郁和焦虑水平分别提高了 1.4%、7.6%、4.4%、2.6% 和 0.4%。这些改善在统计学上具有重要意义。干预组和常规护理组的 DASS-21 评分与 EQ-5D3L 指数和视觉模拟量表 (VAS) 评分均呈显著负相关,这表明当常见精神障碍减少时,EQ5D3L 也随之改善:NCT03678415
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引用次数: 0
Human-fecal microbiota transplantation in relation to gut microbiome signatures in animal models for schizophrenia: A scoping review 人类粪便微生物群移植与精神分裂症动物模型中肠道微生物群特征的关系:范围综述
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-24 DOI: 10.1016/j.ajp.2024.104285
Raghunath Singh , Kristoffer Panganiban , Emily Au , Rekha Ravikumar , Sandra Pereira , Thomas D. Prevot , Daniel J. Mueller , Gary Remington , Sri Mahavir Agarwal , Elena F. Verdu , Premysl Bercik , Giada De Palma , Margaret K. Hahn
More recently, attention has turned to the putative role of gut microbiome (GMB) in pathogenesis, symptomatology, treatment response and/or resistance in schizophrenia (SCZ). It is foreseeable that fecal microbiota transplantation (FMT) from SCZ patients (SCZ-FMT) to germ-free mice could represent a suitable experimental framework for a better understanding of the relationship between GMB and SCZ. Thus, we set out to identify literature (i) characterizing the GMB in animal models of SCZ, and (ii) employing SCZ-FMT into rodents to model SCZ in relation to behavioral and molecular phenotypes. Five studies examining animal models of SCZ suggest distinct GMB composition compared to respective control groups, which was correlated with SCZ-like behavioral phenotypes. Four additional studies investigated SCZ-FMT into rodents in relation to behavioral phenotypes, including spontaneous hyperlocomotion, social deficits, exaggerated startle response, and cognitive impairments, resembling those observed in SCZ patients. Mice receiving SCZ-FMT showed altered neurochemical and metabolic pathways in the brain. Animal models of SCZ have shown altered GMB composition, whereas reported behavioral and neurochemical alterations following FMT from patients into rodents suggest early face and construct validity for SCZ-FMT animal models. However, the predictive validity of these models remains to be validated.
最近,人们开始关注肠道微生物组(GMB)在精神分裂症(SCZ)的发病机制、症状、治疗反应和/或抗药性中的作用。可以预见,将精神分裂症(SCZ)患者的粪便微生物群(FMT)移植到无菌小鼠体内,是更好地了解肠道微生物群与精神分裂症(SCZ)之间关系的合适实验框架。因此,我们开始寻找以下文献:(i) 描述 SCZ 动物模型中 GMB 特征的文献;(ii) 将 SCZ-FMT 移植到啮齿类动物体内以建立 SCZ 行为和分子表型模型的文献。五项关于 SCZ 动物模型的研究表明,与各自的对照组相比,GMB 的组成与 SCZ 类行为表型相关。另有四项研究调查了啮齿类动物的SCZ-FMT与行为表型的关系,包括自发性运动过度、社交障碍、夸张的惊吓反应和认知障碍,这些都与在SCZ患者身上观察到的表型相似。接受SCZ-FMT治疗的小鼠表现出大脑神经化学和代谢途径的改变。SCZ动物模型显示了GMB组成的改变,而据报道,从患者到啮齿类动物的FMT后的行为和神经化学改变表明了SCZ-FMT动物模型的早期面貌和构造的有效性。然而,这些模型的预测有效性仍有待验证。
{"title":"Human-fecal microbiota transplantation in relation to gut microbiome signatures in animal models for schizophrenia: A scoping review","authors":"Raghunath Singh ,&nbsp;Kristoffer Panganiban ,&nbsp;Emily Au ,&nbsp;Rekha Ravikumar ,&nbsp;Sandra Pereira ,&nbsp;Thomas D. Prevot ,&nbsp;Daniel J. Mueller ,&nbsp;Gary Remington ,&nbsp;Sri Mahavir Agarwal ,&nbsp;Elena F. Verdu ,&nbsp;Premysl Bercik ,&nbsp;Giada De Palma ,&nbsp;Margaret K. Hahn","doi":"10.1016/j.ajp.2024.104285","DOIUrl":"10.1016/j.ajp.2024.104285","url":null,"abstract":"<div><div>More recently, attention has turned to the putative role of gut microbiome (GMB) in pathogenesis, symptomatology, treatment response and/or resistance in schizophrenia (SCZ). It is foreseeable that fecal microbiota transplantation (FMT) from SCZ patients (SCZ-FMT) to germ-free mice could represent a suitable experimental framework for a better understanding of the relationship between GMB and SCZ. Thus, we set out to identify literature (i) characterizing the GMB in animal models of SCZ, and (ii) employing SCZ-FMT into rodents to model SCZ in relation to behavioral and molecular phenotypes. Five studies examining animal models of SCZ suggest distinct GMB composition compared to respective control groups, which was correlated with SCZ-like behavioral phenotypes. Four additional studies investigated SCZ-FMT into rodents in relation to behavioral phenotypes, including spontaneous hyperlocomotion, social deficits, exaggerated startle response, and cognitive impairments, resembling those observed in SCZ patients. Mice receiving SCZ-FMT showed altered neurochemical and metabolic pathways in the brain. Animal models of SCZ have shown altered GMB composition, whereas reported behavioral and neurochemical alterations following FMT from patients into rodents suggest early face and construct validity for SCZ-FMT animal models. However, the predictive validity of these models remains to be validated.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"102 ","pages":"Article 104285"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Default at fault? Exploring neural correlates of default mode network in children with ADHD, their unaffected siblings versus neurotypical controls: A quantitative EEG study 默认模式有问题?探索多动症儿童及其未受影响的兄弟姐妹与神经典型对照组默认模式网络的神经相关性:脑电图定量研究。
IF 3.8 4区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-24 DOI: 10.1016/j.ajp.2024.104291
Chaithanya Leon , Simran Kaur , Rajesh Sagar , Prashant Tayade , Ratna Sharma

Background

Sustained activation of default mode network has been implicated for momentary lapses of attention and higher errors during performance of cognitive tasks in attention deficit hyperactive disorder (ADHD) children. Despite emerging evidence indicating the genetic basis of ADHD, there is paucity of literature investigating the alteration of DMN in children with ADHD and their unaffected siblings.

Aim

To study the cortical sources of DMN in children with ADHD compared to their siblings and neurotypical controls.

Methods

Eighty-six participants (35 ADHD (12.4(±2.7) years), 16 unaffected siblings (11.8(±4.3) years) and 35 matched neurotypical controls (12.6 (±3.6) years) participated in the study. 128 channel EEG data was acquired during rest and Stroop cognitive task and analyzed for cortical source estimation using LORETA software.

Results

Higher activation of DMN and DMN associated areas were observed during encoding of the color-word stimuli in children with ADHD. Sustained activation of core DMN areas namely medial frontal gyrus, posterior cingulate gyrus, parahippocampal gyrus and inferior parietal lobule was observed across all groups. Among the three groups, distinct cortical source activation differences were identified solely in the DMN and its associated areas among children with ADHD during the task encoding phase compared to baseline. In contrast, both siblings and neurotypical controls displayed activation in fronto-parieto-temporal areas subserving executive function were also observed.

Conclusion

Sustained activity of DMN areas with minimal activity in executive network in ADHD children and unaffected siblings during encoding of stimulus implies potential endophenotypic marker in children with ADHD compared to neurotypical controls.
背景:默认模式网络的持续激活被认为与注意力缺陷多动障碍(ADHD)儿童在完成认知任务过程中的瞬间注意力缺失和较高错误率有关。尽管有新的证据表明ADHD有遗传基础,但研究ADHD儿童及其未受影响的兄弟姐妹的DMN改变的文献却很少。目的:研究ADHD儿童与他们的兄弟姐妹和神经典型对照组相比的DMN皮层来源:86名参与者(35名多动症儿童(12.4(±2.7)岁)、16名未受影响的兄弟姐妹(11.8(±4.3)岁)和35名匹配的神经典型对照组儿童(12.6(±3.6)岁)参加了研究。研究人员采集了128个通道的静息和Stroop认知任务时的脑电图数据,并使用LORETA软件进行皮层源估算分析:结果:在对颜色-文字刺激进行编码时,观察到多动症儿童的DMN和DMN相关区域的激活程度较高。在所有组别中都观察到了DMN核心区域(即额叶内侧回、扣带回后部、海马旁回和顶叶下部)的持续激活。在三个组别中,与基线相比,多动症儿童在任务编码阶段仅在 DMN 及其相关区域发现了明显的皮质源激活差异。相比之下,同胞兄弟姐妹和神经典型对照组的前颞区辅助执行功能的区域也出现了激活:结论:与神经典型对照组相比,多动症儿童和未受影响的兄弟姐妹在刺激编码期间DMN区域持续活跃,而执行网络的活动极少,这意味着多动症儿童存在潜在的内表型标记。
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引用次数: 0
期刊
Asian journal of psychiatry
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