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Using human-robot interaction to assess emotion recognition in dialysis patients: A preliminary study. 使用人机交互来评估透析患者的情绪识别:初步研究。
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-05 DOI: 10.1016/j.ajp.2026.104878
Concetta De Pasquale, Maria Luisa Pistorio, Helene Høgsdal, Carla Cirasa, Daniela Conti

This cross-sectional observational study examined the relationship between psychological factors and multimodal emotion recognition abilities in patients with chronic kidney disease (CKD), introducing a humanoid robot as an innovative assessment modality. Sixty adults undergoing dialysis and awaiting renal transplantation (63.3 % male; mean age = 53.95 years, range 20-80) completed three emotion recognition tasks based on Ekman facial expressions, dynamic video clips, and emotional displays performed by the NAO humanoid robot, together with validated measures of alexithymia (TAS-20), anxiety (GAD-7), and depression (PHQ-9). Regression analyses showed that performance on the Ekman task was positively predicted by education and anxiety levels (β =.26, p = .037; β =.26, p = .043). Recognition of emotions in videos was negatively predicted by age (β = -.45, p < .001) and alexithymia (β = -.37, p = .002). For the robot-based task, increasing age (β = -.30, p = .020) and longer dialysis duration (β =.31, p = .017) significantly predicted recognition accuracy. Logistic regression analyses indicated that alexithymia negatively predicted recognition of disgust in videos and fear expressed by the robot. Levels of anxiety positively predicted recognition of happiness and fear in the Ekman test. Across the modalities, alexithymia and age emerged as core factors associated with reduced emotion recognition, with video and robot-based tasks capturing these differences more clearly than static facial stimuli. These findings suggest that socially assistive robots may represent a promising tool for detecting subtle socio-emotional processing alterations in medically vulnerable populations, supporting future longitudinal research integrating technological and psychological assessment.

本横断面观察性研究探讨了慢性肾脏疾病(CKD)患者的心理因素与多模态情绪识别能力之间的关系,并引入了一种仿人机器人作为创新的评估方式。60名接受透析和等待肾移植的成年人(63.3 %男性,平均年龄53.95岁,范围20-80岁)完成了三项情绪识别任务,这些任务基于Ekman面部表情、动态视频剪辑和NAO类人机器人的情绪显示,以及经过验证的述情障碍(TAS-20)、焦虑(GAD-7)和抑郁(PHQ-9)测量。回归分析显示,教育程度和焦虑水平正预测Ekman任务的表现(β = 0.26, p = .037;β = 0.26, p = .043)。对视频中情绪的识别与年龄呈负相关(β = - 0.45, p
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引用次数: 0
Does improvement in attention through theta/beta neurofeedback training result in better entry-level vocational task performance in individuals with schizophrenia? An open-label randomised controlled trial. 通过θ / β神经反馈训练对注意力的改善是否会使精神分裂症患者的入门级职业任务表现更好?一项开放标签随机对照试验。
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-02 DOI: 10.1016/j.ajp.2026.104880
Aanchal Narang, Devvarta Kumar, Jagadisha Thirthalli, Aarti Jagannathan

The presence of cognitive deficits in schizophrenia is unequivocally established. These deficits impact the socio-occupational functioning of the individual. Consequently, enhancing cognitive functions is a key goal of comprehensive treatment approaches. Of late, neurofeedback has shown promise in improving cognitive abilities; however, research in the schizophrenia population remains scarce. The present study aimed to evaluate the efficacy of neurofeedback in enhancing speed, accuracy, and productivity on entry-level vocational activities. Thirty-four individuals with schizophrenia underwent 15 sessions of neurofeedback designed to attenuate theta and late beta activities while augmenting early beta activity. A wait-list control group (N = 34) of schizophrenia patients was used for comparison. Results indicated that the neurofeedback group had improved speed, accuracy, and productivity on the entry-level vocational tasks, potentially due to enhanced alertness and attention. Additionally, cognitive assessments also revealed improvements in attention and information processing. These findings suggest that a brief, targeted neurofeedback protocol can enhance vocational task performance in individuals with schizophrenia.

精神分裂症中存在认知缺陷是明确确定的。这些缺陷影响个人的社会职业功能。因此,增强认知功能是综合治疗方法的关键目标。最近,神经反馈在提高认知能力方面显示出了希望;然而,对精神分裂症人群的研究仍然很少。本研究旨在评估神经反馈在提高入门级职业活动的速度、准确性和生产力方面的功效。34名精神分裂症患者接受了15次神经反馈,旨在减弱θ波和晚期β波活动,同时增强早期β波活动。以待诊精神分裂症患者为对照(N = 34)。结果表明,神经反馈组在入门级职业任务上的速度、准确性和效率都有所提高,这可能是由于警觉性和注意力的增强。此外,认知评估也显示了注意力和信息处理的改善。这些发现表明,一个简短的、有针对性的神经反馈方案可以提高精神分裂症患者的职业任务表现。
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引用次数: 0
The letter to editor regarding "National-, institutional-, and individual-level determinants of psychiatric research excellence: Analysis of Stanford-Elsevier lists of the top 2 % scholars worldwide (2017-2023)". 致编辑关于“精神病学研究卓越性的国家、机构和个人层面的决定因素:斯坦福-爱思唯尔全球排名前2 %学者名单分析(2017-2023)”的信。
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-02 DOI: 10.1016/j.ajp.2026.104883
Jiayi Chen
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引用次数: 0
Atypical neuropsychiatric withdrawal syndrome following abrupt cessation of chronic nitrous oxide use: A case report. 突然停止慢性氧化亚氮使用后的非典型神经精神戒断综合征:一例报告。
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-02 DOI: 10.1016/j.ajp.2026.104882
Chung Nguyen Viet, Bruce Boman, Chien Nguyen Huu, Quan Nguyen Trong
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引用次数: 0
Health literacy and the continuum of suicidal behaviors among adults: A national survey from South Korea, 2023. 健康素养和成年人自杀行为的连续性:韩国2023年的一项全国性调查。
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-02 DOI: 10.1016/j.ajp.2026.104884
Seong-Uk Baek, Jin-Ha Yoon
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引用次数: 0
Advancing psychotherapy in Malaysian psychiatric practice: The role of the psychotherapy chapter of the Malaysian Psychiatric Association. 在马来西亚精神病实践中推进心理治疗:马来西亚精神病协会心理治疗分会的作用。
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-02 DOI: 10.1016/j.ajp.2026.104877
Chong Seng Choi, Nik Ruzyanei Nik Jaafar
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引用次数: 0
Ten sessions, faster response, or faster exit? Clarifying "Speed" and cost claims in piTBS vs 10-Hz rTMS. 十个会话,更快的响应,还是更快的退出?澄清piTBS和10hz rTMS的“速度”和成本要求。
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-02 DOI: 10.1016/j.ajp.2026.104881
Xiaowei Zhang
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引用次数: 0
Impaired task-switching in major depressive disorder: A time-frequency analysis of non-emotional and emotional stimuli. 重度抑郁症的任务转换受损:非情绪和情绪刺激的时频分析。
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-02 DOI: 10.1016/j.ajp.2026.104879
Kaili Zheng, Wanrong Peng, Zhaoxia Liu, Xiaoshuang Gu, Meiqian Tang, Weijun Situ, Jinyao Yi

Background: Major depressive disorder (MDD) is characterized by significant impairments in cognitive functions, including task-switching dysfunction. This study investigates the differences in switching impairments between non-emotional and emotional switching tasks in MDD patients and explores the underlying neuropsychological mechanisms.

Methods: 48 MDD patients and 52 healthy controls (HCs) were recruited. Behavioral and electroencephalogram data were recorded while participants performed non-emotional and emotional task-switching paradigms. Event-related potentials (ERPs: P2, N2, P3 difference waves) and event-related spectral perturbations (ERSPs: theta, alpha, beta band power) were analyzed to assess group differences.

Results: In the magnitude task, MDD group displayed reduced occipital Pd2 amplitude (p < 0.001, η2p=0.20), increased frontal/central Pd3 amplitudes (p < 0.001, η2p=0.10), and larger alpha power differences (p < 0.05, η2p= 0.04). In the gender task, MDD group had increased occipital Pd2 amplitude (p < 0.05, η2p=0.04) and larger alpha power differences in the P3 time window (p < 0.01, η2p=0.03). In the emotion task, MDD group showed prolonged Pd2 latency (p < 0.05, η2p=0.04), reduced Pd3 amplitude (p < 0.05, η2p=0.10), smaller theta power differences (p = 0.05, η2p=0.03), and larger beta power differences (p < 0.05, η2p=0.04).

Conclusion: MDD patients exhibit a dissociable pattern of task-switching deficits across non-emotional and emotional task-switching scenarios, characterized by distinct abnormalities across early visual processing, conflict monitoring, cognitive resource allocation, and multi-stage emotional processing. This study reveals novel electrophysiological mechanisms underlying cognitive inflexibility in MDD.

背景:重度抑郁症(MDD)的特征是认知功能的显著损伤,包括任务转换功能障碍。本研究探讨重度抑郁症患者非情绪性和情绪性转换任务的转换障碍差异,并探讨其潜在的神经心理学机制。方法:选取48例重度抑郁症患者和52例健康对照。当参与者进行非情绪和情绪任务转换范式时,记录他们的行为和脑电图数据。分析事件相关电位(ERPs: P2、N2、P3差波)和事件相关谱扰动(ERSPs: θ、α、β波段功率)来评估组间差异。结果:在幅度任务中,MDD组枕部Pd2幅值降低(p 2p=0.20),额部/中央Pd3幅值增加(p 2p=0.10), alpha功率差异较大(p 2p= 0.04)。在性别任务中,MDD组枕部Pd2振幅增加(p 2p=0.04), P3时间窗α功率差异更大(p 2p=0.03)。在情绪任务中,MDD组Pd2潜伏期延长(p 2p=0.04), Pd3振幅减小(p 2p=0.10), θ功率差异较小(p = 0.05,η2p=0.03), β功率差异较大(p 2p=0.04)。结论:MDD患者在非情绪性和情绪性任务转换情景中表现出可分离的任务转换缺陷模式,其特征是在早期视觉加工、冲突监测、认知资源分配和多阶段情绪加工中表现出明显的异常。本研究揭示了重度抑郁症认知不灵活性的新电生理机制。
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引用次数: 0
Molecular evidence associating GLP-1 receptor agonists and brain-derived neurotrophic factors in neurodegenerative and psychiatric disorders: A systematic review GLP-1受体激动剂和脑源性神经营养因子在神经退行性和精神疾病中的分子证据:一项系统综述
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-29 DOI: 10.1016/j.ajp.2026.104870
Tianyi Xu , Yang Jing Zheng , Sabrina Wong , Christine E. Dri , Xin Tong Zhou , Kayla M. Teopiz , Gia Han Le , Roger S. McIntyre

Background

A converging mechanistic theme across mental disorders involves impaired neuroplasticity and reduced brain-derived neurotrophic factor (BDNF). Glucagon-like peptide-1 receptor agonists (GLP-1RAs), used for type 2 diabetes and obesity, have shown neuroprotective potential, but whether these effects are mediated by BDNF is unclear.

Objective

This systematic review synthesised molecular evidence linking GLP-1RA administration to BDNF changes and evaluated their contribution to illness progression in neurodegenerative and psychiatric disorders.

Methods

A systematic search of PubMed, Ovid and Google Scholar from inception to September 6, 2025, identified studies reporting BDNF-related outcomes following GLP-1RA treatment. Eligible studies included primary in vivo or in vitro research on GLP-1RAs in models of neurodegenerative or psychiatric disorders. Risk of bias was assessed using SYRCLE and QUIN tools.

Results

The initial search yielded 300 records, of which 18 met the inclusion criteria. Across these studies, GLP-1RAs consistently enhanced BDNF expression and signalling in models of diabetes, neurodegeneration and neurotoxicity, with diabetic models included for their relevance to GLP-1RA pharmacology and shared neuroinflammatory pathway. Reported increases in BDNF expression ranged from 76 % to 377 %, correlating with improved synaptic plasticity, cognition and neuronal survival. In vitro, GLP-1 and exendin-4 increased BDNF expression and axonal transport even under Aβ oligomer exposure. While most neuroprotection aligned with BDNF upregulation, some effects occurred independently through alternative pathways.

Conclusion

GLP-1RAs upregulate BDNF in preclinical models, supporting its role as a key mediator of neuroprotection. Despite some BDNF-independent actions, the consistent restoration of neurotrophic support positions BDNF as a central pathway for disease modification.
精神障碍的一个趋同机制主题涉及神经可塑性受损和脑源性神经营养因子(BDNF)减少。胰高血糖素样肽-1受体激动剂(GLP-1RAs)用于治疗2型糖尿病和肥胖症,已显示出神经保护潜力,但这些作用是否由BDNF介导尚不清楚。目的:本系统综述综合了GLP-1RA与BDNF变化相关的分子证据,并评估其在神经退行性疾病和精神疾病进展中的作用。方法系统检索PubMed、Ovid和谷歌Scholar从成立到2025年9月6日,确定了报告GLP-1RA治疗后bdnf相关结果的研究。符合条件的研究包括GLP-1RAs在神经退行性或精神疾病模型中的体内或体外初步研究。使用cycle和QUIN工具评估偏倚风险。结果初步检索得到300条记录,其中18条符合纳入标准。在这些研究中,GLP-1RAs在糖尿病、神经变性和神经毒性模型中持续增强BDNF的表达和信号传导,其中包括糖尿病模型,因为它们与GLP-1RA药理学和共享的神经炎症途径相关。据报道,BDNF表达的增加范围从76% %到377 %,与突触可塑性、认知和神经元存活的改善相关。在体外,即使在Aβ低聚物暴露下,GLP-1和exendin-4也能增加BDNF的表达和轴突运输。虽然大多数神经保护与BDNF上调一致,但一些作用通过其他途径独立发生。结论lp - 1ras在临床前模型中上调BDNF,支持其作为神经保护的关键介质的作用。尽管有一些BDNF独立的作用,但神经营养支持的持续恢复使BDNF成为疾病改变的中心途径。
{"title":"Molecular evidence associating GLP-1 receptor agonists and brain-derived neurotrophic factors in neurodegenerative and psychiatric disorders: A systematic review","authors":"Tianyi Xu ,&nbsp;Yang Jing Zheng ,&nbsp;Sabrina Wong ,&nbsp;Christine E. Dri ,&nbsp;Xin Tong Zhou ,&nbsp;Kayla M. Teopiz ,&nbsp;Gia Han Le ,&nbsp;Roger S. McIntyre","doi":"10.1016/j.ajp.2026.104870","DOIUrl":"10.1016/j.ajp.2026.104870","url":null,"abstract":"<div><h3>Background</h3><div>A converging mechanistic theme across mental disorders involves impaired neuroplasticity and reduced brain-derived neurotrophic factor (BDNF). Glucagon-like peptide-1 receptor agonists (GLP-1RAs), used for type 2 diabetes and obesity, have shown neuroprotective potential, but whether these effects are mediated by BDNF is unclear.</div></div><div><h3>Objective</h3><div>This systematic review synthesised molecular evidence linking GLP-1RA administration to BDNF changes and evaluated their contribution to illness progression in neurodegenerative and psychiatric disorders.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Ovid and Google Scholar from inception to September 6, 2025, identified studies reporting BDNF-related outcomes following GLP-1RA treatment. Eligible studies included primary in vivo or in vitro research on GLP-1RAs in models of neurodegenerative or psychiatric disorders. Risk of bias was assessed using SYRCLE and QUIN tools.</div></div><div><h3>Results</h3><div>The initial search yielded 300 records, of which 18 met the inclusion criteria. Across these studies, GLP-1RAs consistently enhanced BDNF expression and signalling in models of diabetes, neurodegeneration and neurotoxicity, with diabetic models included for their relevance to GLP-1RA pharmacology and shared neuroinflammatory pathway. Reported increases in BDNF expression ranged from 76 % to 377 %, correlating with improved synaptic plasticity, cognition and neuronal survival. In vitro, GLP-1 and exendin-4 increased BDNF expression and axonal transport even under Aβ oligomer exposure. While most neuroprotection aligned with BDNF upregulation, some effects occurred independently through alternative pathways.</div></div><div><h3>Conclusion</h3><div>GLP-1RAs upregulate BDNF in preclinical models, supporting its role as a key mediator of neuroprotection. Despite some BDNF-independent actions, the consistent restoration of neurotrophic support positions BDNF as a central pathway for disease modification.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"117 ","pages":"Article 104870"},"PeriodicalIF":4.5,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Magnetic seizure therapy versus electroconvulsive therapy for major mental disorders: A systematic review” [Asian J. Psychiatry 103 (2025) 104336] “磁性癫痫治疗与电惊厥治疗对重大精神障碍的系统评价”的勘误表[Asian J. Psychiatry 103 (2025) 104336]
IF 4.5 4区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-29 DOI: 10.1016/j.ajp.2026.104875
Zhan-Ming Shi , Zhi-Ang Su , Ting Ning , Wei Zheng
{"title":"Corrigendum to “Magnetic seizure therapy versus electroconvulsive therapy for major mental disorders: A systematic review” [Asian J. Psychiatry 103 (2025) 104336]","authors":"Zhan-Ming Shi ,&nbsp;Zhi-Ang Su ,&nbsp;Ting Ning ,&nbsp;Wei Zheng","doi":"10.1016/j.ajp.2026.104875","DOIUrl":"10.1016/j.ajp.2026.104875","url":null,"abstract":"","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"117 ","pages":"Article 104875"},"PeriodicalIF":4.5,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Asian journal of psychiatry
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