Jieqiong Zhao , Zhongchao Gai , Juan Zhang , Ran Zhao , Xiaoli Liu , Yan Li
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引用次数: 0
Abstract
Background
Heart failure (HF) is a global health issue that affects over 64 million people worldwide. Numerous recent epidemiological and experimental studies have revealed that the supplementation of dietary flavonoids and modulation of gut microbiota can independently or dependently impact the progression of heart failure. However, there are currently rare systematic review of the interplay between dietary flavonoids, gut microbiota, and heart failure.
Scope and approach
This article reviews a selection of experimental and clinical studies from PubMed during 2014–2023, which explore the anti-HF effects and respective molecular mechanisms of dietary flavonoids and highlights the interplay between flavonoids, gut microbiota, and heart failure. In this review, we first summarized the pathogenesis and emerging intervention strategies for heart failure. Then, we reviewed the cardio-protective function of flavonoids and the roles of gut microbiota in the pathogenesis of heart failure. Finally, we reviewed the intricate interplay between flavonoids, gut microbiota, and heart failure.
Key findings and conclusions
Flavonoids have the potential to modulate the gut microbiota composition and function, while the gut microbiota can metabolize flavonoids into bioactive compounds that may offer cardio-protective effects. Moreover, heart failure conditions also could affect the composition and function of gut microbiota. In the future, collaborative endeavors across disciplines encompassing nutrition, medicine, epidemiology, and microbiology will advance the understanding of the complicated interplay between dietary flavonoids, gut microbiota, and heart failure, and ultimately facilitate the development of gut microbiota- and dietary flavonoids-based therapeutic strategies for heart failure.
期刊介绍：
Trends in Food Science & Technology is a prestigious international journal that specializes in peer-reviewed articles covering the latest advancements in technology, food science, and human nutrition. It serves as a bridge between specialized primary journals and general trade magazines, providing readable and scientifically rigorous reviews and commentaries on current research developments and their potential applications in the food industry.
Unlike traditional journals, Trends in Food Science & Technology does not publish original research papers. Instead, it focuses on critical and comprehensive reviews to offer valuable insights for professionals in the field. By bringing together cutting-edge research and industry applications, this journal plays a vital role in disseminating knowledge and facilitating advancements in the food science and technology sector.
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