Prostaglandins suppress neutrophil function after sexual intercourse and may promote urinary tract infections

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Medical hypotheses Pub Date : 2024-09-15 DOI:10.1016/j.mehy.2024.111481

Gabriel Mayoral Andrade , Eduardo Perez Campos , Juan de Dios Ruiz-Rosado , Emiliano G. Mayoral Canseco , Angela Lee , Gabriela Vasquez-Martinez

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Abstract

Sexually active women have an increased risk of urinary tract infections (UTIs), which may be influenced by components in seminal plasma. Prostaglandins in seminal plasma are key modulators of the immune system and maternal-fetal immunological tolerance, influencing cells like platelets and neutrophils. Specifically, prostaglandin I2 (PGI2) inhibits platelet aggregation, while prostaglandin E2 (PGE2) alters neutrophil activity, including the production of reactive oxygen species (ROS) and the formation of neutrophil extracellular traps (NETs). Given that the NET response is associated with UTIs, and PGI2 is known to modulate NETs, these interactions may contribute to the higher incidence of UTIs in sexual activity in women. This study aims to investigate whether UTIs following sexual activity are facilitated by an imbalance in NET formation mediated by prostaglandins. We employed four search strategies: Sex and UTI, NETs and UTIs, Prostaglandins and NETs, and Inflammasome and NETs, alongside a review of original research publications. By understanding this mechanism, we hope to reveal how prostaglandin-mediated immune modulation may increase susceptibility to UTIs after sexual activity.

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前列腺素会抑制性交后中性粒细胞的功能，并可能促进尿路感染

性生活活跃的女性患尿路感染（UTI）的风险增加，这可能受到精浆中成分的影响。精浆中的前列腺素是免疫系统和母胎免疫耐受的关键调节剂，会影响血小板和中性粒细胞等细胞。具体来说，前列腺素 I2（PGI2）可抑制血小板聚集，而前列腺素 E2（PGE2）可改变中性粒细胞的活性，包括产生活性氧（ROS）和形成中性粒细胞胞外捕获物（NET）。鉴于 NET 反应与 UTIs 有关，而已知 PGI2 可调节 NETs，这些相互作用可能是导致女性在性活动中 UTIs 发生率较高的原因。本研究旨在探讨前列腺素介导的 NET 形成失衡是否会导致性活动后尿毒症的发生。我们采用了四种搜索策略：性与UTI、NET与UTI、前列腺素与NET、炎症体与NET，并对原始研究出版物进行了回顾。通过了解这一机制，我们希望揭示前列腺素介导的免疫调节是如何增加性活动后UTI的易感性的。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.