Gambogic acid and IR780 self-assembled nanoparticles for combined chemo-phototherapy

IF 5.4 2区医学 Q1 BIOPHYSICS Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-17 DOI:10.1016/j.colsurfb.2024.114254

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Abstract

Combined chemo-phototherapy has shown considerable advantages and potential in cancer treatment. For this purpose, self-assembled nanoparticles by gambogic acid (GA) and IR780 (referred to as GA-IR780 NPs) were prepared. Herein, GA, an active compound derived from Garcinia hanburyi Hook.f, was selected as a chemo-agent. IR780 was used as a photothermal agent as well as a photosensitizer, which could kill tumor cells via photothermal effect and photodynamic effect. The obtained GA-IR780 NPs were uniform spheres with particle size of ca. 50 nm. The drug loading efficiency of GA and IR780 was 38.42 % and 56.64 %, respectively. The GA-IR780 NPs exhibited excellent photothermal properties as well as photodynamic effect when irradiated by near infrared (NIR) light (808 nm, 2.0 W/cm²). Moreover, the GA-IR780 NPs showed enhanced cytotoxicity with NIR light activation. Results of animal experiments showed that GA-IR780 NPs had the most significant tumor inhibition when irradiated by laser, and the results of H&E, Ki-67 and TUNEL staining confirmed that the GA-IR780 NPs+Laser group caused the most severe tumor tissue damage. The above results indicated that GA-mediated chemotherapy combining with IR780-based phototherapy could significantly improve the anti-tumor efficacy.

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用于联合化疗和光疗的甘草酸和 IR780 自组装纳米粒子

联合化疗和光疗在癌症治疗中具有相当大的优势和潜力。为此，研究人员制备了甘果酸（GA）和 IR780 自组装纳米粒子（简称 GA-IR780 NPs）。其中，甘果酸（GA）是一种提取自甘草（Garcinia hanburyi Hook.f）的活性化合物，被选为化疗剂。IR780既是光热剂，又是光敏剂，可通过光热效应和光动力效应杀死肿瘤细胞。得到的 GA-IR780 NPs 为粒径约为 50 nm 的均匀球体。GA和IR780的载药效率分别为38.42%和56.64%。在近红外（NIR）光（808 nm，2.0 W/cm2）照射下，GA-IR780 NPs 表现出优异的光热特性和光动力效应。此外，GA-IR780 NPs 在近红外光的激活下显示出更强的细胞毒性。动物实验结果表明，GA-IR780 NPs 在激光照射下对肿瘤的抑制作用最明显，H&E、Ki-67 和 TUNEL 染色结果证实，GA-IR780 NPs+ 激光组对肿瘤组织的损伤最严重。上述结果表明，GA介导的化疗与基于IR780的光疗相结合，可显著提高抗肿瘤疗效。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.