Recent development of CE-ICP-MS in biospeciation research and analysis: From anticancer drugs to nanoparticles and beyond

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL Trends in Analytical Chemistry Pub Date : 2024-09-10 DOI:10.1016/j.trac.2024.117967

Magdalena Matczuk , Lena Ruzik , Andrei R. Timerbaev

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Abstract

Capillary electrophoresis (CE) coupled to ICP-MS occupies its rightful place in mainstream biospeciation analysis, where this coupling is certainly much more than a complementary tool to the other separation-based techniques. This brief review critically discusses the current and emerging capabilities of CE-ICP-MS in the simultaneous detection of chemical species of a given element occurring in samples of biological origin, with a particular focus placed on the areas of metal-based drug and nanoparticle research. The most advantageous separation and detection strategies and the method's analytical performance are illustrated with a selection of real-world applications from recent literature. Among the methodological trends, using tandem and single-particle ICP-MS technology steadily moves to the frontline. Further progress in the field would keep step with more reliable, versatile, and robust CE-ICP-MS assays suitable for routine use.

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CE-ICP-MS 在生物降解研究和分析中的最新发展：从抗癌药物到纳米粒子及其他

毛细管电泳（CE）与 ICP-MS 联用在主流生物辐射分析中占据了应有的地位，这种联用当然不仅仅是其他分离技术的补充工具。这篇简短的综述批判性地讨论了 CE-ICP-MS 在同时检测生物样本中出现的特定元素化学物种方面的现有和新兴功能，尤其侧重于基于金属的药物和纳米粒子研究领域。本文从最近的文献中选取了一些实际应用，说明了最有优势的分离和检测策略以及该方法的分析性能。在方法论趋势中，使用串联和单粒子 ICP-MS 技术正稳步走向前沿。该领域的进一步发展将使 CE-ICP-MS 分析法更加可靠、多用途和稳健，适合常规使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.