The potential therapeutic effect of human umbilical cord mesenchymal stem cell-derived exosomes in bronchopulmonary dysplasia

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Life sciences Pub Date : 2024-09-12 DOI:10.1016/j.lfs.2024.123047

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Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants, with its incidence rising due to improved survival rates of these infants. BPD results from a combination of prenatal and postnatal factors, such as mechanical ventilation, oxygen toxicity, and infections, all of which significantly impact the prognosis and growth of affected infants. Current treatment options for BPD are largely supportive and do not address the underlying pathology. Exosomes are cell-derived bilayer-enclosed membrane structures enclosing proteins, lipids, RNAs, growth factors, cytokines and metabolites. They have become recognized as crucial regulators of intercellular communication in various physiological and pathological processes. Previous studies have revealed the therapeutic potential of human umbilical cord mesenchymal stem cells-derived exosomes (HUCMSCs-Exos) in promoting tissue repair and regeneration. Therefore, HUCMSCs-Exos maybe a promising and effective therapeutic modality for BPD. In this review, we firstly provide a comprehensive overview of BPD, including its etiology and the mechanisms of lung injury. Then we detail the isolation, characterization, and contents of HUCMSCs-Exos, and discuss their potential mechanisms of HUCMSCs-Exos in BPD treatment. Additionally, we summarize current clinical trials and discuss the challenges in translating these findings from bench to bedside. This review aims to lay the groundwork for future clinical applications of HUCMSCs-Exos in treating BPD.

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人脐带间充质干细胞衍生的外泌体对支气管肺发育不良的潜在治疗作用

支气管肺发育不良（BPD）是早产儿的一种慢性肺部疾病，随着早产儿存活率的提高，其发病率也在不断上升。BPD 是产前和产后因素（如机械通气、氧中毒和感染）共同作用的结果，所有这些因素都会严重影响患儿的预后和生长。目前治疗 BPD 的方法主要是支持性治疗，并不能解决潜在的病理问题。外泌体是细胞衍生的双层封闭膜结构，内含蛋白质、脂质、RNA、生长因子、细胞因子和代谢物。外泌体被认为是各种生理和病理过程中细胞间通信的关键调节因子。先前的研究揭示了人脐带间充质干细胞衍生的外泌体（HUCMSCs-Exos）在促进组织修复和再生方面的治疗潜力。因此，人脐带间充质干细胞外泌体可能是治疗 BPD 的一种有前景且有效的方法。在这篇综述中，我们首先全面概述了 BPD，包括其病因和肺损伤机制。然后，我们详细介绍了 HUCMSCs-Exos 的分离、表征和内容，并讨论了 HUCMSCs-Exos 治疗 BPD 的潜在机制。此外，我们还总结了当前的临床试验，并讨论了将这些研究成果从实验室转化到临床所面临的挑战。本综述旨在为 HUCMSCs-Exos 治疗 BPD 的未来临床应用奠定基础。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.