Effects of chronic social defeat stress on social behavior and cognitive flexibility for early and late adolescent

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Behavioural Brain Research Pub Date : 2024-09-11 DOI:10.1016/j.bbr.2024.115251
Hsin-Yung Chen , Hou-Yu Chiang , Ting-Hein Lee , Pei-Ying Sarah Chan , Chia-Yen Yang , Hsin-Min Lee , Sophie Hsin-Yi Liang
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Abstract

This study investigated the risk to social behavior and cognitive flexibility induced by chronic social defeat stress (CSDS) during early and late adolescence (EA and LA). Utilizing the “resident-intruder” stress paradigm, adolescent male Sprague-Dawley rats were exposed to CSDS during either EA (postnatal days 29–38) or LA (postnatal days 39–48) to explore how social defeat at different stages of adolescence affects behavioral and cognitive symptoms commonly associated with psychiatric disorders. After stress exposure, the rats were assessed for anxiety-like behavior in the elevated plus maze, social interaction, and cognitive flexibility through set-shifting and reversal-learning tasks under immediate and delayed reward conditions. The results showed that CSDS during EA, but not LA, led to impaired cognitive flexibility in adulthood, as evidenced by increased perseverative and regressive errors in the set-shifting and reversal-learning tasks, particularly under the delayed reward condition. This suggests that the timing of stress exposure during development has a significant impact on the long-term consequences for behavioral and cognitive function. The findings highlight the vulnerability of the prefrontal cortex, which undergoes critical maturation during early adolescence, to the effects of social stress. Overall, this study demonstrates that the timing of social stressors during adolescence can differentially shape the developmental trajectory of cognitive flexibility, with important implications for understanding the link between childhood/adolescent adversity and the emergence of psychiatric disorders.

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长期社会失败压力对青少年早期和晚期社会行为和认知灵活性的影响
本研究调查了慢性社会挫败应激(CSDS)在青春期早期和晚期(EA和LA)诱发的社会行为和认知灵活性风险。利用 "居民-入侵者 "应激范式,将雄性斯普拉格-道利(Sprague-Dawley)青春期大鼠暴露于EA(出生后第29-38天)或LA(出生后第39-48天)期间的CSDS,以探讨青春期不同阶段的社会挫败如何影响通常与精神障碍相关的行为和认知症状。在应激暴露后,对大鼠在高架加迷宫中的焦虑样行为、社会交往以及在即时和延迟奖励条件下通过集合转移和反向学习任务进行的认知灵活性进行了评估。结果表明,EA期间的CSDS(而非LA)会导致成年后认知灵活性受损,这表现在设定转移和逆向学习任务中的坚持性错误和回归性错误增加,尤其是在延迟奖励条件下。这表明,在发育过程中暴露于压力的时机对行为和认知功能的长期后果有重大影响。研究结果凸显了前额叶皮层在青春期早期经历关键成熟期时容易受到社会压力的影响。总之,这项研究表明,青春期社会压力的时间会对认知灵活性的发展轨迹产生不同的影响,这对理解童年/青春期逆境与精神障碍的出现之间的联系具有重要意义。
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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