Behavioural Brain Research最新文献

Corrigendum to "Network pharmacology integrated with pharmacological evaluation for investigating the mechanism of resveratrol in perimenopausal depression" [Behav. Brain Res. 477 (2025) 115304]. “网络药理学与药理学评价结合研究白藜芦醇治疗围绝经期抑郁症的机制”的勘误表[行为。中国生物医学工程学报，2015(5):344 - 349。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-05-28 Epub Date: 2026-03-16 DOI: 10.1016/j.bbr.2026.116163

Ye Zhang, Li Gui, Yan Yin, Xiaona Tong, Guobin Xia, Yuanyuan Wang, Jingting Yi, Chunyan Tian, Xiaobo Liu, Hongling Yang

引用次数: 0

Hippocampal energy metabolism reprogramming underlies individual differences in paroxetine-facilitated contextual fear extinction. 海马体能量代谢重编程是帕罗西汀促进情境恐惧消退的个体差异的基础。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-05-28 Epub Date: 2026-03-14 DOI: 10.1016/j.bbr.2026.116162

Zhixin Fan, Xiayu Gong, Hanfang Xu, Hongwei Wang, Guangfu Chen

Individual variability in response to selective serotonin reuptake inhibitors (SSRIs) remains a major challenge in the treatment of anxiety-related disorders. Impaired fear extinction is a core feature of stress-related psychopathologies. Although chronic SSRI administration has been shown to enhance fear extinction, the biological basis underlying differential treatment responsiveness is poorly understood. In the present study, we examined hippocampal molecular alterations associated with divergent behavioral responses to chronic paroxetine treatment in a contextual fear extinction paradigm. Based on freezing behavior during the extinction retention test, paroxetine-treated rats were stratified into high- and low-response subgroups. Data-independent acquisition-based proteomics revealed pronounced alterations in pathways related to synaptic function, mitochondrial processes, and metabolic regulation in the hippocampus of paroxetine high responders. Subsequent targeted metabolite quantification further implicated multiple energy-related pathways, including the pentose phosphate pathway, purine metabolism, and the tricarboxylic acid cycle, as metabolic features associated with divergent contextual fear extinction phenotypes, accompanied by altered levels of pathway-specific metabolites. These results suggest that adaptive hippocampal energy metabolism reprogramming may support divergent fear extinction phenotypes following chronic paroxetine treatment, providing mechanistic insight into differential treatment effects in fear-related disorders.

个体对选择性5 -羟色胺再摄取抑制剂（SSRIs）反应的差异性仍然是焦虑相关疾病治疗中的一个主要挑战。恐惧消退受损是压力相关精神病理的核心特征。虽然长期服用SSRI已被证明可以增强恐惧消退，但差异治疗反应的生物学基础尚不清楚。在本研究中，我们在情境恐惧消退范式中研究了与慢性帕罗西汀治疗的不同行为反应相关的海马分子改变。根据消失保留试验中的冻结行为，将帕罗西汀治疗大鼠分为高反应组和低反应组。基于数据独立获取的蛋白质组学揭示了帕罗西汀高反应者海马突触功能、线粒体过程和代谢调节相关通路的显著改变。随后的目标代谢物量化进一步暗示了多种能量相关途径，包括戊糖磷酸途径、嘌呤代谢和三羧酸循环，这些代谢特征与不同的情境恐惧消退表型相关，并伴随着途径特异性代谢物水平的改变。这些结果表明，适应性海马能量代谢重编程可能支持慢性帕罗西汀治疗后不同的恐惧消退表型，为恐惧相关疾病的不同治疗效果提供了机制见解。

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引用次数: 0

Targeting orofacial pain: From pathophysiological mechanisms to Traditional Chinese Medicine approaches. 针对口面部疼痛：从病理生理机制到中医方法。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-05-28 Epub Date: 2026-03-15 DOI: 10.1016/j.bbr.2026.116165

Wen-Bo Liu, Yan-Qing Wang, Yu-Xia Chu

Orofacial pain is a heterogeneous group of painful conditions affecting the facial and oral regions that can substantially impair quality of life. In some patients, stimulus-evoked pain manifestations such as allodynia further aggravate the disease burden. Current drugs, including carbamazepine and pregabalin, offer only partial relief and are limited by adverse effects, underscoring the need for alternative therapeutic strategies. Traditional Chinese Medicine (TCM), characterized by holistic and multi-targeted actions, shows therapeutic promise. This review summarizes recent advances in peripheral and central mechanisms of orofacial pain, emphasizing ion channel dysregulation, central sensitization, neuroinflammation, and gut-brain axis modulation. We further evaluate TCM-derived phytochemicals, including resveratrol, curcumin, and α-bisabolol. These compounds act by modulating neuroimmune pathways, suppressing glial activation, restoring synaptic plasticity, and rebalancing gut microbiota. Finally, we highlight challenges-such as standardization, biomarker-guided diagnostics, and the lack of large-scale clinical trials-and propose future directions. By linking traditional insights with contemporary neuroscience, this review aims to provide a mechanistic framework for effective, personalized, and sustainable therapies.

口腔面部疼痛是一种影响面部和口腔区域的不同种类的疼痛状况，可以严重损害生活质量。在一些患者中，刺激引起的疼痛表现，如异常性疼痛，进一步加重了疾病负担。目前的药物，包括卡马西平和普瑞巴林，只能提供部分缓解，并且受到不良反应的限制，强调需要替代治疗策略。中医以其整体和多靶点的作用为特点，显示出治疗的前景。本文综述了口面部疼痛的外周和中枢机制的最新进展，重点介绍了离子通道失调、中枢致敏、神经炎症和肠-脑轴调节。我们进一步评估了中药衍生的植物化学物质，包括白藜芦醇、姜黄素和α-双酚醇。这些化合物通过调节神经免疫通路、抑制胶质细胞激活、恢复突触可塑性和重新平衡肠道微生物群而起作用。最后，我们强调了挑战，如标准化、生物标志物引导的诊断和缺乏大规模临床试验，并提出了未来的方向。通过将传统观点与当代神经科学相结合，本综述旨在为有效、个性化和可持续的治疗提供一个机制框架。

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引用次数: 0

Non-pharmacotherapy for craving in methamphetamine use disorder: A systematic review and network meta-analysis of randomised controlled trials 非药物治疗对甲基苯丙胺使用障碍的渴望：随机对照试验的系统回顾和网络荟萃分析。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-04-27 Epub Date: 2026-02-06 DOI: 10.1016/j.bbr.2026.116084

Jisheng Xu , Xue Li , Zhicheng Zhu , Junwei Wang , Yan Yang , Xulin Zhou , Guosi Ying

Objectives

We evaluated the effects of non-pharmacotherapy on quality of life (QOL) and craving in individuals with methamphetamine use disorder (MUD), ranking the efficacy of various protocols.

Methods

We searched multiple databases for randomized controlled trials from inception to Dec 2025. The analysis included 53 studies with 3174 participants, investigating interventions such as exercise, transcranial magnetic stimulation (TMS), transcranial direct current stimulation, behavioral therapy, and acupuncture. The protocol was prospectively registered in PROSPERO (CRD42023443291).

Results

For craving reduction, both exercise and TMS demonstrated statistically significant benefits compared to conventional rehabilitation. Combined aerobic/resistance exercise and 10 Hz repetitive TMS targeting the left dorsolateral prefrontal cortex emerged as the most effective specific protocols within their respective categories. Furthermore, preliminary evidence from a limited number of studies indicated that exercise, acupuncture, and behavioral therapy improved patients' QOL.

Conclusion

This study confirms that several non-pharmacotherapies are effective for managing craving in MUD. Exercise and TMS are particularly promising for reducing craving. The findings, synthesized within a novel "Intervention-Circuit-Symptom" integrative framework, provide a robust evidence base to inform clinical decision-making and guide the future development of MUD treatment guidelines.

目的：我们评估非药物治疗对甲基苯丙胺使用障碍（MUD）患者生活质量（QOL）和渴望的影响，并对各种治疗方案的疗效进行排名。方法：我们检索了多个数据库从成立到2025年12月的随机对照试验。这项分析包括53项研究，涉及3174名参与者，调查了锻炼、经颅磁刺激（TMS）、经颅直流电刺激、行为疗法和针灸等干预措施。该方案在PROSPERO （CRD42023443291）进行了前瞻性注册。结果：在减少渴望方面，与传统康复相比，运动和经颅磁刺激均显示出统计学上显著的益处。有氧/阻力联合运动和针对左背外侧前额叶皮层的10Hz重复性经颅磁刺激是各自类别中最有效的具体方案。此外，来自有限数量研究的初步证据表明，运动、针灸和行为疗法改善了患者的生活质量。结论：本研究证实了几种非药物治疗方法对控制MUD患者的渴望是有效的。运动和经颅磁刺激对减少渴望尤其有效。这些发现在一个新的“干预-回路-症状”综合框架内进行了综合，为临床决策提供了强有力的证据基础，并指导了MUD治疗指南的未来发展。

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引用次数: 0

Combined transcranial electrical stimulation (tES) and cognitive training (CT) for cognitive impairment: Evidence from clinical applications and basic research 联合经颅电刺激（tES）和认知训练（CT）治疗认知障碍：来自临床应用和基础研究的证据。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-04-27 Epub Date: 2026-02-02 DOI: 10.1016/j.bbr.2026.116078

Shu Xing , Yuan Yuan , Ping Ren , Zhuangfei Chen , Yu Fu

Cognitive impairment is a serious pathological feature of neuropsychiatric disorders, making the exploration of effective treatments urgent. Recent research shows that combined transcranial electrical stimulation (tES) and cognitive training (CT) can reduce cognitive deficits. This review summarizes studies on neurological disorders that use both clinical patients and rodent models to highlight the underlying neural mechanisms. In patients, this combined approach improves cognitive domains such as attention, working memory, and executive function. Improvements have been observed in patients with mild cognitive impairment (MCI), dementia (e.g., Alzheimer’s disease (AD)), Parkinson’s disease (PD), stroke, traumatic brain injury (TBI), multiple sclerosis, schizophrenia, attention deficit hyperactivity disorder (ADHD) and depression, as well as in healthy populations. In contrast, studies on the combined intervention are lacking in rodent models of disease. However, tES and CT separately improve spatial learning and memory in AD, TBI, schizophrenia, ADHD, and healthy animals, as well as in models of vascular dementia and cerebral ischemia. The combined intervention regulates and remodels functional connectivity in brain networks, and improves cerebrovascular microcirculation and glutamatergic neurotransmission. Importantly, tES and CT may enhance each other through cooperative and complementary effects. In addition, some studies have reported the limited efficacy or negative outcomes of combined and single interventions, which may be due to suboptimal parameters or techniques that fail to target key pathologies. Future clinical trials should explore tES-CT combination strategies targeting disease-specific brain regions. Furthermore, animal studies must be strengthened to elucidate the potential mechanisms and interactions of tES and CT.

认知障碍是神经精神疾病的严重病理特征，迫切需要探索有效的治疗方法。最近的研究表明，经颅电刺激（tES）和认知训练（CT）相结合可以减少认知缺陷。本文综述了神经系统疾病的研究，包括临床患者和啮齿动物模型，以突出潜在的神经机制。在患者中，这种综合方法可以改善认知领域，如注意力、工作记忆和执行功能。在轻度认知障碍（MCI）、痴呆症（如阿尔茨海默病（AD））、帕金森病（PD）、中风、创伤性脑损伤（TBI）、多发性硬化症、精神分裂症、注意缺陷多动障碍（ADHD）和抑郁症患者以及健康人群中都观察到改善。相比之下，在啮齿动物疾病模型中缺乏联合干预的研究。然而，tES和CT分别改善了AD、TBI、精神分裂症、ADHD和健康动物以及血管性痴呆和脑缺血模型的空间学习和记忆。联合干预调节和重塑脑网络功能连接，改善脑血管微循环和谷氨酸能神经传递。重要的是，tES和CT可以通过合作和互补效应来相互促进。此外，一些研究报告了联合干预和单一干预的有限疗效或负面结果，这可能是由于次优参数或未能针对关键病理的技术。未来的临床试验应探索针对疾病特异性脑区域的tES-CT联合策略。此外，必须加强动物研究，以阐明tES和CT的潜在机制和相互作用。

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引用次数: 0

The effects of acute and repeated adolescent MDMA exposure on behavior, cognition, and the monoamine neurotransmitter systems: A review of human and pre-clinical research 青少年MDMA急性和反复暴露对行为、认知和单胺神经递质系统的影响：人类和临床前研究综述

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-04-27 Epub Date: 2026-02-10 DOI: 10.1016/j.bbr.2026.116098

Kristin A. Felsch, Jessica A. Siegel

3,4-methylenedioxymethamphetamine (MDMA) is a psychomotor stimulant drug. While much research has examined the effects of MDMA in adults, relatively little research has examined the effects in adolescents. Adolescence is a unique period of brain development, and the effects of MDMA may differ in adolescents compared to adults. In this review, we summarize the literature on the effects of acute and repeated adolescent MDMA exposure on behavior, cognition, and the monoamine neurotransmitter systems in adolescent rodents and humans. PubMed was searched using predefined criteria, resulting in the evaluation of 1012 articles. Fifty-four articles met the search criteria, 48 of which examined the effects of adolescent MDMA exposure in adolescent rodents and 6 of which examined the effects in adolescent humans. Studies measuring the effects of acute MDMA exposure examine outcome measures following a single exposure to MDMA, and studies measuring the effects of repeated MDMA exposure examine outcome measures at some point following multiple exposures to MDMA. Exposure to acute higher doses of MDMA generally increases locomotor activity and causes impairments in the serotonin neurotransmitter system. The literature on the effects of repeated adolescent MDMA exposure shows conflicting results, and the findings are dependent on the dosing, testing environment, and timing of testing following MDMA exposure. There is a lack of literature examining the effects of MDMA in adolescent females. More research is needed with consistent exposure and dosing paradigms and in female subjects to better understand the effects of adolescent MDMA exposure.

3,4-亚甲基二氧甲基苯丙胺（MDMA）是一种精神运动兴奋剂。虽然有很多研究调查了MDMA对成年人的影响，但相对较少的研究调查了它对青少年的影响。青少年是大脑发育的独特时期，与成年人相比，MDMA对青少年的影响可能有所不同。在这篇综述中，我们总结了急性和反复的青少年MDMA暴露对青少年啮齿动物和人类的行为、认知和单胺类神经递质系统的影响。使用预定义的标准搜索PubMed，结果对1012篇文章进行了评估。54篇文章符合搜索标准，其中48篇研究了青少年接触MDMA对啮齿动物的影响，6篇研究了青少年接触MDMA对人类的影响。测量急性MDMA暴露影响的研究检查了单次MDMA暴露后的结果测量，测量重复MDMA暴露影响的研究检查了多次MDMA暴露后某一时刻的结果测量。暴露于急性高剂量的MDMA通常会增加运动活动并导致血清素神经递质系统的损伤。关于青少年反复接触MDMA的影响的文献显示了相互矛盾的结果，这些结果取决于MDMA暴露后的剂量、测试环境和测试时间。缺乏研究MDMA对青春期女性影响的文献。为了更好地了解青少年MDMA暴露的影响，需要对女性受试者进行更多的一致暴露和剂量范例研究。

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引用次数: 0

Concurrent Serial Feature Negative and Simple Discrimination Training and Testing in the Mouse 小鼠并发序列特征阴性和简单鉴别训练与试验

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-04-27 Epub Date: 2026-02-11 DOI: 10.1016/j.bbr.2026.116100

Negar Ghasem Ardabili , Jordyn Pettiford , Alexia Hyde , Charlotte Airosus , Anthony L. Riley , Terry. L. Davidson

Prior research shows that rats can solve serial feature negative (serFN) and simple discrimination (SD) problems when both are trained concurrently. Furthermore, previous studies indicate that the solution to the serFN (but not the SD) problem depends on the functional integrity of the hippocampus. The present research aimed to determine if mice solve the serFN problem and if this is solved in a manner mediated by inhibitory modulation similar to that seen in rats. Establishing if mice, like rats, can solve the serFN problem using a potentially hippocampal-dependent strategy would provide researchers with greater flexibility when selecting research tools to investigate hippocampal-dependent memory functioning. In Experiment 1, male and female C57BL6J mice were concurrently trained on serFN (Light→Tone−, Tone+) and SD (Clicker+, White Noise−) problems, following which they were injected with cocaine. Animals acquired both discriminations, and subsequent performance was not affected by cocaine administration (unlike impairments reported with rats). Summation and retardation tests argued against a direct inhibitory association for serFN performance and indicated a modulatory form of inhibition. In Experiment 2, male and female C57BL6J mice were similarly trained on serFN and SD problems and then exposed to a Western-style diet for 12 days following training. Animals acquired both discriminations. Western diet consumption selectively impaired serFN performance while leaving SD performance intact (similar to effects reported in rats). Together, these findings demonstrate that mice can solve serFN discrimination. The basis for such learning appears to be modulatory inhibitory control, possibly mediated by the hippocampus.

先前的研究表明，大鼠在同时训练时可以解决序列特征阴性（serFN）和简单辨别（SD）问题。此外，先前的研究表明，serFN（而不是SD）问题的解决取决于海马体的功能完整性。本研究旨在确定小鼠是否解决了serFN问题，以及是否以类似于在大鼠中看到的抑制调节介导的方式解决了这个问题。确定小鼠是否能像大鼠一样，利用潜在的海马体依赖策略来解决serFN问题，将为研究人员选择研究工具来研究海马体依赖记忆功能提供更大的灵活性。在实验1中，雄性和雌性C57BL6J小鼠同时接受serFN （Light→Tone -, Tone+）和SD （Clicker+, White Noise -）问题的训练，然后注射可卡因。动物获得了这两种辨别能力，随后的表现不受可卡因给药的影响（与大鼠报道的损伤不同）。总结和延迟试验反对直接抑制与血清fn性能的联系，并指出了一种调节形式的抑制。在实验2中，雄性和雌性C57BL6J小鼠同样进行了serFN和SD问题的训练，然后在训练后给予西式饮食12天。动物获得了这两种辨别能力。西方饮食选择性地损害了血清fn的表现，而使SD的表现完好无损（与在大鼠中报道的效果相似）。总之，这些发现表明小鼠可以解决serFN歧视问题。这种学习的基础似乎是调节性抑制控制，可能由海马体介导。

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引用次数: 0

Toxin-induced conditioned disgust responses: Comparing emetine and scopolamine methyl nitrate (SMN) to lithium chloride (LiCl) 毒素诱导的条件厌恶反应：比较艾美汀和东莨菪碱甲基硝酸（SMN）与氯化锂（LiCl）。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-04-27 Epub Date: 2026-02-06 DOI: 10.1016/j.bbr.2026.116087

Grace E. Lake , Lily Wang , Mustafa Al-Khudairy , Martin Kavaliers , Klaus-Peter Ossenkopp

Chemotherapy patients often develop anticipatory nausea, a learned response produced by an environmental cue triggering nausea in the absence of the emetic stimulus. This can be modelled in rats by pairing the administration of an emetic treatment with exposure to a distinct context. Rats are a non-emetic species, but they are still capable of experiencing nausea, which is observable through the presence of the gaping response. The rat model of anticipatory nausea mainly utilizes lithium chloride (LiCl) to evoke the gaping response, yet various other putative emetic toxins and agents have remained unexplored. The current study determined if emetine, found in ipecac, and scopolamine methyl nitrate (SMN), a derivative of scopolamine, can evoke the conditioned gaping response. Adult male Long Evans rats (n = 40) were administered emetine (5.0 mg/kg, intraperitoneal [i.p.]), SMN (0.5 or 1.0 mg/kg, i.p.), LiCl (127 mg/kg, i.p.), or sodium chloride (NaCl, 0.9 %, i.p., control) before exposure to a distinct context for 30 min, over four conditioning trials, followed by four extinction (drug-free) trials. During the extinction trials, no treatments were administered, and rats were placed directly into the context. Rat behaviour on all of the trials was videotaped and scored for the frequency of the conditioned gaping response. Findings from this study suggest that, in comparison to LiCl, emetine is an effective conditioning stimulus, whereas SMN is not.

化疗患者通常会出现预期性恶心，这是一种习得性反应，是在没有呕吐刺激的情况下，由环境提示引发的恶心。这可以通过将呕吐治疗与暴露于不同环境相结合在大鼠身上进行模拟。大鼠是一种不呕吐的物种，但它们仍然能够经历恶心，这是通过存在的张开反应观察到的。预期性恶心的大鼠模型主要利用氯化锂（LiCl）来唤起张口反应，但各种其他可能的呕吐毒素和药物仍未被探索。目前的研究确定了在吐根中发现的艾美汀和东莨菪碱的衍生物硝酸甲基东莨菪碱（SMN）是否能引起条件张口反应。40只成年雄性Long Evans大鼠，腹腔注射艾美汀（5.0mg/kg）。])、SMN（0.5或1.0mg/kg, i.p.）、LiCl （127mg/kg, i.p.）或氯化钠（NaCl, 0.9%, i.p.，对照），然后在不同的环境中暴露30分钟，进行4次调节试验，然后进行4次消失（无药物）试验。在灭绝试验期间，没有进行任何治疗，大鼠直接被置于环境中。所有实验中的大鼠行为都被录像，并根据条件张口反应的频率进行评分。本研究结果表明，与LiCl相比，艾美汀是一种有效的条件反射刺激，而SMN则不是。

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引用次数: 0

Targeting the prefrontal-supplementary motor network with online and offline tDCS to modulate disgust: A single-blind and sham-controlled study 在线和离线tDCS针对前额叶-辅助运动网络调节厌恶：单盲和假对照研究。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-04-27 Epub Date: 2026-02-02 DOI: 10.1016/j.bbr.2026.116077

Parastoo Soltani , Zekrollah Morovati , Majid Yousefi Afrashteh , Jakob Fink-Lamotte , Jaber Alizadehgoradel

In certain individuals, disgust experience is abnormally high. This heightened sensitivity serves as a cognitive component that can lead to dysfunction in neural circuits related to emotion processing and psychological disorders such as contamination-based obsessive-compulsive disorder. In this single-blind study, 36 individuals with high disgust sensitivity were randomly assigned to three groups: online, offline, and sham. The online group received intensified and repetitive transcranial direct current stimulation (tDCS) while performing a disgust image watching task, whereas the offline and sham groups performed the task at two time points: immediately before (pre-test) and immediately after (post-test) the stimulation session. The offline group received active tDCS, whereas the sham group received placebo tDCS to control for the interval duration. Anodal and cathodal stimulation was applied to the left dorsolateral prefrontal cortex (l-DLPFC; F3) and pre-supplementary motor area (pre-SMA; FC2), respectively. The intervention consisted of 10 sessions of tDCS (2 sessions per day) over 5 days, with a stimulation intensity of 2 mA for 20 min and a 20-minute interval between sessions. The results showed a significant decrease in disgust experience in the online group compared to the offline group, while there was no significant difference between the online and sham groups. Although these findings suggest potential effects of tDCS combined with a task, further studies are necessary to confirm its efficacy.

在某些个体中，厌恶体验异常高。这种高度的敏感性作为一种认知成分，可能导致与情绪处理和心理障碍（如基于污染的强迫症）相关的神经回路功能障碍。在这项单盲研究中，36名高厌恶敏感性的人被随机分为三组：在线组、离线组和假组。在线组在执行厌恶图像观看任务时接受强化和重复的经颅直流电刺激（tDCS），而离线组和假组在两个时间点执行任务：刺激之前（测试前）和之后（测试后）。离线组接受主动tDCS，而假手术组接受安慰剂tDCS来控制间隔时间。分别对左背外侧前额叶皮层（l-DLPFC; F3）和前辅助运动区（pre-SMA; FC2）施加阳极和阴极刺激。干预包括10次tDCS（每天2次），持续5天，刺激强度为2mA，每次20分钟，每次之间间隔20分钟。结果显示，与离线组相比，在线组的厌恶体验显著减少，而在线组和假组之间没有显著差异。尽管这些发现表明tDCS与任务相结合的潜在影响，但需要进一步的研究来证实其有效性。

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引用次数: 0

Association between executive dysfunction and mild to severe upper extremity deficits in stroke survivors: A resting state functional near-infrared spectroscopy study 脑卒中幸存者执行功能障碍与轻度至重度上肢功能障碍之间的关系：静息状态功能近红外光谱研究

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2026-04-27 Epub Date: 2026-02-04 DOI: 10.1016/j.bbr.2026.116082

Man Wang , Lijun Zhang , Cheng Xie , Zhaoxu Hu , Ru Ya , Hao Huang , Changhui Sun , Yulong Bai , Yan Hua

Objects

We aimed to observe the association between executive function and mild to severe upper extremity deficits in stroke survivors. Meanwhile, applying functional Near-Infrared Spectroscopy (fNIRS) to investigate the resting-state functional connectivity (FC) patterns of patients with post-stroke executive impairment (PSEI).

Methods

122 stroke survivors with mild to severe upper extremity deficits were enrolled. The Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), and Stroop color-word test assessed cognitive and executive function. The Fugl-Meyer assessment of the upper extremity (FMA-UE) and Action Research Arm Test (ARAT) assessed motor function. They were collected fNIRS data at the resting state.

Results

(1) In patients with mild to moderate upper extremity deficits, PSEI patients exhibited decreased speed/coordination of the upper extremity compared to the NPSEI patients (P < 0.05). The MoCA (r = 0.280, P = 0.047) and FAB (r = 0.358, P = 0.010) were associated with the speed/coordination. PSEI patients showed a decreased FC between the left dorsolateral prefrontal cortex (DLPFC) and the right Pre-Motor and Supplementary Motor Cortex (PreM&SMC), the right primary Somatosensory Cortex (PSMC) (P < 0.05); (2) In patients with severe upper extremity deficits, PSEI patients showed a reduction in FMA and ARAT (P < 0.05). The MoCA was associated with ARAT (r = 0.296, P = 0.016) and FMA-UE (r = 0.317, P = 0.009). The FAB was related to ARAT (r = 0.263, P = 0.033) and FMA-UE (r = 0.295, P = 0.016). PSEI patients did not show a significant change in FC (P ＞ 0.05).

Conclusion

Our study suggests that the association between executive function and upper extremity after stroke is associated with the degree of upper extremity deficits. Additionally, the FC among cortical and subcortical brain regions were different with varying degrees of upper extremity deficits in PSEI patients.

目的：我们旨在观察脑卒中幸存者执行功能与轻度至重度上肢功能缺陷之间的关系。同时，应用功能性近红外光谱（fNIRS）研究脑卒中后执行功能障碍（PSEI）患者静息状态功能连接（FC）模式。方法：纳入122例轻度至重度上肢功能障碍的脑卒中幸存者。蒙特利尔认知评估（MoCA），正面评估电池（FAB）和Stroop颜色单词测试评估认知和执行功能。Fugl-Meyer上肢评估（FMA-UE）和动作研究臂测试（ARAT）评估运动功能。在静息状态下收集近红外光谱数据。结果：结论：本研究提示脑卒中后执行功能与上肢功能的关系与上肢功能缺损程度有关。此外，皮质和皮质下脑区的FC在PSEI患者不同程度的上肢缺陷中是不同的。

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