RAFT polymerization assisted P(NIPAm-co-AAc)-AEMR integrated PVA hydrogels: Dual responsive features, texture analysis, and cytotoxicity studies

IF 4.5 3区工程技术 Q1 CHEMISTRY, APPLIED Reactive & Functional Polymers Pub Date : 2024-09-12 DOI:10.1016/j.reactfunctpolym.2024.106052

P.A. Parvathy , Sriparna De , Manjinder Singh , Gaurav Manik , Sushanta K. Sahoo

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Abstract

Modified P(NIPAm-co-AAc) copolymers are prepared using Radical Addition Fragmentation Chain Transfer (RAFT) copolymerization by varying the concentration of castor oil sourced acrylated epoxy methyl ricinoleate (AEMR). Subsequently, hydrogels are prepared by integrating copolymers with polyvinyl alcohol (PVA) via freeze-thaw process. The employment of RAFT polymerization yielded copolymers with dispersity (D) value of 1.2–1.3 revealing the formation of structurally well controlled polymer chains. The lower critical solution temperature (LCST) of the copolymers (∼30–35 °C) are tuned to the range of physiological temperature (∼37 °C) in PVA hydrogel system. Temperature dependent viscoelastic properties indicated that the characteristics of copolymeric solutions and hydrogels are composition dependent while undergoing noncovalent interactions and the conformational changes and the samples showed extremely elastic behaviour beyond LCST. Swelling ratio of hydrogels are also found to be pH dependent, which displayed higher swelling ratio in alkaline and reduced swelling ratio in acidic medium. Cytotoxicity studies with L929 cells showed that the copolymers and hydrogels exhibited desirable biocompatibility, which gets improved with AEMR concentrations. Thus, these dual responsive PA-AEMR-PVA smart hydrogels can be used as a viable functional material for possible bio-medical applications.

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RAFT 聚合辅助 P(NIPAm-co-AAc)-AEMR 集成 PVA 水凝胶：双重响应特性、质地分析和细胞毒性研究

通过改变蓖麻油来源的丙烯酸环氧甲基蓖麻油酸酯（AEMR）的浓度，采用自由基加成碎片链转移（RAFT）共聚法制备改性 P（NIPAm-co-AAc）共聚物。随后，通过冻融过程将共聚物与聚乙烯醇（PVA）结合，制备出水凝胶。采用 RAFT 聚合工艺制备的共聚物的分散度（D）值为 1.2-1.3，表明聚合物链的形成在结构上得到了很好的控制。共聚物的低临界溶液温度（LCST）（∼30-35 °C）与 PVA 水凝胶体系的生理温度（∼37 °C）范围一致。与温度相关的粘弹性表明，共聚物溶液和水凝胶的特性与组成有关，同时还经历了非共价相互作用和构象变化，样品在 LCST 之后表现出极高的弹性。水凝胶的溶胀率也与 pH 值有关，在碱性介质中溶胀率较高，而在酸性介质中溶胀率较低。用 L929 细胞进行的细胞毒性研究表明，共聚物和水凝胶具有理想的生物相容性，并随着 AEMR 浓度的增加而得到改善。因此，这些双响应 PA-AEMR-PVA 智能水凝胶可作为一种可行的功能材料用于生物医学应用。

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来源期刊

Reactive & Functional Polymers 工程技术-高分子科学

CiteScore

8.90

自引率

5.90%

发文量

259

审稿时长

27 days

期刊介绍： Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.