多发性硬化症（MS）的目标是中枢神经系统（CNS）神经元的髓鞘。多发性硬化症是由自反应性 CD4+ T 细胞引发的，而肥胖与多发性硬化症风险的增加有关，尤其是对女性而言。为了进一步研究这些性别依赖性炎症特征，研究人员使用了饮食诱导肥胖（DIO）小鼠模型和实验性自身免疫性脑脊髓炎（EAE），后者是一种T细胞对髓鞘具有自身反应性的多发性硬化症小鼠模型。雌性小鼠与雄性小鼠相比，DIO（与正常体重的EAE对照组相比）在更大程度上加剧了EAE的进展和症状。
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Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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