Patient Factors Associated with 10-Year Survival After Arthroplasty for Hip Fracture: A Population-Based Study in Ontario, Canada.

Mina Tohidi,George Grammatopoulos,Stephen M Mann,Alexandra Pysklywec,Patti A Groome
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Abstract

BACKGROUND The aim of this study was to describe long-term (10-year) patient survival after arthroplasty for hip fracture and to determine what patient factors are associated with that outcome. METHODS We performed a retrospective cohort analysis of patients ≥60 years old who underwent either hemiarthroplasty or total hip arthroplasty for femoral neck fracture between 2002 and 2009. We used routinely collected, validated health-care databases linked through ICES (formerly known as the Institute for Clinical Evaluative Sciences). We estimated the association between baseline variables and survival 10 years post-fracture using Poisson regression. Restricted cubic spline functions modeled the probability of 10-year survival by age and tested whether there was an inflection point after which the probability of 10-year survival decreased more rapidly. We estimated 10-year survival probabilities for different patient groups. RESULTS There were 19,659 patients in the final cohort. Eighteen percent (3,564) of the patients were alive at 10 years postoperatively. Factors associated with a higher likelihood of 10-year survival included younger age, female sex (risk ratio [RR] = 1.56, 95% confidence interval [CI] = 1.46 to 1.68), lower American Society of Anesthesiologists (ASA) class (ASA I or II versus IV or V: RR = 1.96, 95% CI = 1.76 to 2.19), independent living status (RR = 2.68, 95% CI = 2.23 to 3.22), and fewer specific comorbidities. A threshold age of 73 years was the inflection point after which the probability of 10-year survival decreased more rapidly in females. Estimated 10-year survival probabilities ranged from 79.0% (95% CI = 75.5% to 82.5%) to 0.8% (95% CI = 0.6% to 1.0%). CONCLUSIONS Approximately 1 in 6 patients live at least 10 years following a hip fracture. This study identifies baseline characteristics that predict survival greater than 10 years, including an age of <75 years, an ASA class of I or II, and independent living status prior to the hip fracture. Results can inform discussions around treatment choices, anticipated outcomes, and the natural history of hip fractures. LEVEL OF EVIDENCE Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
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与髋部骨折关节置换术后 10 年存活率相关的患者因素:加拿大安大略省基于人口的研究。
背景本研究旨在描述髋部骨折关节置换术后患者的长期(10 年)存活率,并确定哪些患者因素与这一结果相关。方法我们对 2002 年至 2009 年期间因股骨颈骨折接受半关节置换术或全髋关节置换术的年龄≥60 岁的患者进行了回顾性队列分析。我们使用的是通过 ICES(前身为临床评价科学研究所)链接的常规收集的、经过验证的医疗保健数据库。我们使用泊松回归估算了基线变量与骨折后 10 年生存率之间的关系。限制立方样条函数按年龄对 10 年存活概率进行建模,并检验是否存在一个拐点,在该拐点之后,10 年存活概率下降得更快。我们估算了不同患者群体的 10 年生存概率。18%的患者(3,564 人)在术后 10 年仍然存活。10年存活率较高的相关因素包括年龄较小、性别为女性(风险比 [RR] = 1.56,95% 置信区间 [CI] = 1.46 至 1.68)、美国麻醉医师协会(ASA)等级较低(ASA I 或 II 与 IV 或 V 相比:RR = 1.96,95% CI = 1.76 至 2.19)、独立生活状态(RR = 2.68,95% CI = 2.23 至 3.22)以及特定合并症较少。73 岁是一个拐点,在这之后,女性的 10 年生存概率下降得更快。估计的 10 年生存概率从 79.0% (95% CI = 75.5% 到 82.5%) 到 0.8% (95% CI = 0.6% 到 1.0%) 不等。本研究确定了可预测存活期超过 10 年的基线特征,包括年龄小于 75 岁、ASA 分级为 I 级或 II 级以及髋部骨折前的独立生活状态。研究结果可为有关治疗选择、预期结果和髋部骨折自然史的讨论提供参考。有关证据等级的完整描述,请参阅 "作者须知"。
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