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Automating Adolescent Idiopathic Scoliosis Classification: An Interpretable, Workflow-Based Approach to Lenke Classification: Commentary on an article by Lingcong Xu, MD, et al.: "A Fully Automated Multistage Deep Learning System for Lenke Classification. Enhanced Diagnostic Precision in Adolescent Idiopathic Scoliosis". 自动化青少年特发性脊柱侧凸分类:一种可解释的、基于工作流的Lenke分类方法:对徐玲丛博士等人的一篇文章的评论:“Lenke分类的全自动多阶段深度学习系统。”提高青少年特发性脊柱侧凸的诊断精度”。
Pub Date : 2026-03-26 DOI: 10.2106/jbjs.26.00074
Xiangjie Yin,Nan Wu
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引用次数: 0
Rebuilding the Research Pipeline: Why Medical Students Struggle in Orthopaedic Scholarship and How the System Can Improve. 重建研究管道:为什么医学生在骨科奖学金中挣扎,以及该系统如何改进。
Pub Date : 2026-03-23 DOI: 10.2106/jbjs.25.01652
Kevin A Wu
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引用次数: 0
"First, Do No Harm": Revisiting the Hippocratic Tradition. “第一,不伤害”:重新审视希波克拉底传统。
Pub Date : 2026-03-20 DOI: 10.2106/jbjs.26.00068
Konstantinos N Malizos
{"title":"\"First, Do No Harm\": Revisiting the Hippocratic Tradition.","authors":"Konstantinos N Malizos","doi":"10.2106/jbjs.26.00068","DOIUrl":"https://doi.org/10.2106/jbjs.26.00068","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
With Gratitude to Dr. Thomas Einhorn, Founding Editor of JBJS Reviews: Honoring a Legacy of Orthopaedic and Editorial Leadership. 感谢Thomas Einhorn博士,JBJS评论的创始编辑:尊重骨科和编辑领导的遗产。
Pub Date : 2026-03-18 DOI: 10.2106/jbjs.26.00094
Mohit Bhandari,Marc F Swiontkowski
{"title":"With Gratitude to Dr. Thomas Einhorn, Founding Editor of JBJS Reviews: Honoring a Legacy of Orthopaedic and Editorial Leadership.","authors":"Mohit Bhandari,Marc F Swiontkowski","doi":"10.2106/jbjs.26.00094","DOIUrl":"https://doi.org/10.2106/jbjs.26.00094","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"57 1","pages":"393-394"},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147471678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical Nuance and Relevance: Reflections on the Trapezium and Acromioclavicular Joint Stability: Commentary on an article by Sara Sugiura, MD, et al.: "The Trapezius Aponeurosis Insertion on the Acromion. An Anatomical Study with a Possible Implication for Dynamic Stabilization of the Acromioclavicular Joint". 解剖上的细微差别和相关性:关于斜方肌和肩锁关节稳定性的思考:对Sara Sugiura, MD等人的一篇文章的评论:“肩峰上的斜方肌腱膜插入”。一项对肩锁关节动态稳定可能有指导意义的解剖学研究。
Pub Date : 2026-03-18 DOI: 10.2106/jbjs.25.01392
Varag Abed
{"title":"Anatomical Nuance and Relevance: Reflections on the Trapezium and Acromioclavicular Joint Stability: Commentary on an article by Sara Sugiura, MD, et al.: \"The Trapezius Aponeurosis Insertion on the Acromion. An Anatomical Study with a Possible Implication for Dynamic Stabilization of the Acromioclavicular Joint\".","authors":"Varag Abed","doi":"10.2106/jbjs.25.01392","DOIUrl":"https://doi.org/10.2106/jbjs.25.01392","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"14 1","pages":"399-400"},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147471675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Promise of the Ultrasonic Bone Scalpel in Osteoid Osteoma: Commentary on an article by He Dong, MD, et al.: "Clinical Application of an Ultrasonic Bone Scalpel in the Treatment of Osteoid Osteoma. A Single-Center Pilot Study". 超声骨刀在骨样骨瘤中的应用前景:何东等人的文章《超声骨刀在骨样骨瘤治疗中的临床应用》述评。单中心试点研究”。
Pub Date : 2026-03-18 DOI: 10.2106/jbjs.25.01287
Yi Guo
{"title":"The Promise of the Ultrasonic Bone Scalpel in Osteoid Osteoma: Commentary on an article by He Dong, MD, et al.: \"Clinical Application of an Ultrasonic Bone Scalpel in the Treatment of Osteoid Osteoma. A Single-Center Pilot Study\".","authors":"Yi Guo","doi":"10.2106/jbjs.25.01287","DOIUrl":"https://doi.org/10.2106/jbjs.25.01287","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"17 1","pages":"397-398"},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147471676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft-Tissue Balance Is Still a Critical Element of Total Knee Arthroplasty: Commentary on an article by Hao-Ming An, MB, et al.: "Impact of the Femoral Pin Tracker on Soft-Tissue Tension in Robotic-Assisted Total Knee Arthroplasty. A Prospective Randomized Controlled Trial". 软组织平衡仍然是全膝关节置换术的关键因素:对安浩明,MB等人的文章《机器人辅助全膝关节置换术中股骨针跟踪器对软组织张力的影响》的评论。前瞻性随机对照试验”。
Pub Date : 2026-03-18 DOI: 10.2106/jbjs.25.01291
Giles R Scuderi
{"title":"Soft-Tissue Balance Is Still a Critical Element of Total Knee Arthroplasty: Commentary on an article by Hao-Ming An, MB, et al.: \"Impact of the Femoral Pin Tracker on Soft-Tissue Tension in Robotic-Assisted Total Knee Arthroplasty. A Prospective Randomized Controlled Trial\".","authors":"Giles R Scuderi","doi":"10.2106/jbjs.25.01291","DOIUrl":"https://doi.org/10.2106/jbjs.25.01291","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"31 1","pages":"395-396"},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147471681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pain Outcomes Following Modern External Ring Fixation Compared with Internal Fixation for Severe Open Tibial Fractures: A Secondary Analysis of a Prospective Randomized Trial (FIXIT). 现代外环固定与内固定治疗严重开放性胫骨骨折的疼痛结局:一项前瞻性随机试验(FIXIT)的二次分析。
Pub Date : 2026-03-18 DOI: 10.2106/jbjs.25.00964
Henry T Shu,Amir Human Hoveidaei,Lisa M Reider,Heather A Vallier,Stephen Quinnan,Joshua L Gary,Eben A Carroll,Anthony R Carlini,Thomas F Higgins,Michael J Bosse,Babar Shafiq,Paul Tornetta,Robert V O'Toole,Renan C Castillo,
BACKGROUNDIt is unclear whether postoperative pain differs by treatment type for patients with severe open tibial fractures.METHODSWe performed a secondary analysis of data from the FIXIT study. Adults with severe open tibial fractures were randomized to undergo definitive modern external ring fixation (n = 122) or internal fixation (n = 132). Primary outcomes were pain intensity and interference at 6 and 12 months, measured by the Brief Pain Inventory. Secondary outcomes were Numeric Pain Rating Scale (NPRS) scores and the incidence of moderate to severe pain. Post hoc subanalysis compared pain in patients with and without pin-site infections and with and without external fixation removal.RESULTSAt 6 months, median pain intensity did not differ significantly between the external fixation group (4.1 [interquartile range (IQR), 2.2 to 5.5]) and the internal fixation group (3.0 [IQR, 1.8 to 5.8]) (p = 0.11); however, patients who underwent external fixation had greater median pain interference (6.0 [IQR, 3.3 to 8.0]) than patients who underwent internal fixation (4.0 [IQR, 1.9 to 7.4]) (p = 0.01). At 12 months, pain intensity, pain interference, and NPRS scores did not differ by treatment type. The overall incidence of moderate to severe pain was 33% at 6 months and 35% at 12 months. At 6 months, pin-site infections were associated with greater pain intensity (p = 0.01) but not greater interference (p = 0.10). At 12 months, the presence of external fixation was associated with greater pain intensity (p = 0.01) and interference (p < 0.01).CONCLUSIONSAt 6 months after a severe open tibial fracture, patients treated with modern external ring fixation had greater pain interference than patients treated with internal fixation, partly because of pin-site infections. No differences in pain interference or intensity were seen at 12 months. At 12 months, patients with external fixation in place had greater pain intensity and interference than those whose external fixation had been removed, but this was not the case at 6 months. Approximately one-third of all patients had moderate to severe pain at both time points, highlighting that persistent pain is common, regardless of treatment type. These findings can guide surgeons in choosing ring external fixation or internal fixation for these fractures.LEVEL OF EVIDENCETherapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
背景:目前尚不清楚严重开放性胫骨骨折患者的术后疼痛是否因治疗方式而异。方法我们对FIXIT研究的数据进行了二次分析。严重胫骨开放性骨折的成人随机接受明确的现代外环固定(n = 122)或内固定(n = 132)。主要结果是6个月和12个月时的疼痛强度和干扰,由简短疼痛量表测量。次要结果是数值疼痛评定量表(NPRS)评分和中度至重度疼痛的发生率。事后亚分析比较了有和没有针位感染的患者以及有和没有取出外固定架的患者的疼痛。结果6个月时,外固定组(4.1[四分位间距(IQR), 2.2 ~ 5.5])和内固定组(3.0 [IQR, 1.8 ~ 5.8])的中位疼痛强度差异无统计学意义(p = 0.11);然而,外固定组患者的中位疼痛干扰(6.0 [IQR, 3.3 ~ 8.0])高于内固定组(4.0 [IQR, 1.9 ~ 7.4]) (p = 0.01)。在12个月时,疼痛强度、疼痛干扰和NPRS评分没有因治疗类型而异。6个月时中重度疼痛的总发生率为33%,12个月时为35%。6个月时,针部感染与更大的疼痛强度相关(p = 0.01),但与更大的干扰无关(p = 0.10)。在12个月时,外固定物的存在与更大的疼痛强度(p = 0.01)和干扰(p < 0.01)相关。结论在严重胫骨开放性骨折6个月后,现代外环固定治疗的患者比内固定治疗的患者有更大的疼痛干扰,部分原因是针位感染。12个月时,疼痛干扰或强度无差异。在12个月时,固定外固定物的患者比移除了外固定物的患者有更大的疼痛强度和干扰,但在6个月时情况并非如此。大约三分之一的患者在两个时间点都有中度至重度疼痛,这表明无论治疗类型如何,持续疼痛都是常见的。这些发现可以指导外科医生选择环形外固定或内固定治疗这些骨折。证据级别:治疗性i级。参见《作者说明》获得证据级别的完整描述。
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引用次数: 0
Periprosthetic Joint Infection Following Total Knee Arthroplasty Is Associated with a Significantly Elevated Risk of Mortality: A Population-Level Database Study. 全膝关节置换术后假体周围关节感染与死亡率显著升高相关:一项人口水平的数据库研究。
Pub Date : 2026-03-13 DOI: 10.2106/jbjs.25.00177
Seper Ekhtiari,Raman Mundi,Daniel Pincus,Emil Schemitsch,J Michael Paterson,Harman Chaudhry,Jerome A Leis,Don Redelmeier,Bheeshma Ravi
BACKGROUNDPeriprosthetic joint infection (PJI) is the most common reason for revision total knee arthroplasty (TKA). Recent evidence has demonstrated that patients who develop PJI within 1 year following total hip arthroplasty have a significantly elevated risk of mortality within 10 years. Thus, the aim of this study was to compare long-term mortality rates between patients who did and did not develop PJI within 1 year following the index TKA.METHODSThis was a retrospective population-level database study. All eligible participants interacted with a single-payer public health-care system. The primary outcome measure was mortality at 10 years following index TKA; 1- and 5-year mortality were also compared. Mortality was compared for propensity-score-matched groups.RESULTSOf the total of 263,204 patients who underwent primary TKA in the study period (mean age and standard deviation, 67.9 ± 9.3 years), 1,228 (0.5%) subsequently developed PJI within 1 year. Across the entire sample, patients who developed PJI within 1 year following the index TKA were more likely to be male, have frailty, and have a Charlson-Deyo score of >0; they also had significantly higher rates of congestive heart failure and chronic obstructive pulmonary disease compared with those who did not develop PJI within 1 year. A total of 1,202 patients who developed PJI within 1 year of the index TKA were matched to 1,202 patients who did not develop PJI within 1 year of the index TKA, with standardized differences of <0.10 for all covariates, indicating a robust match. After matching, TKA recipients who developed PJI in the first year had a significantly higher 10-year mortality rate (7.2% [86] versus 1.6% [19]; absolute risk difference = 5.45% [95% confidence interval (CI) = 3.41% to 7.74%]; hazard ratio = 4.66 [95% CI = 2.84 to 7.66]).CONCLUSIONSPatients who developed PJI within 1 year following TKA were at significantly higher risk for mortality at 10 years post-TKA compared with those who did not develop PJI within 1 year following TKA. The etiological factors leading to this increased risk remain unclear and warrant further investigation alongside efforts to further the prevention, diagnosis, and management of PJI.LEVEL OF EVIDENCETherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
背景:假体周围关节感染(PJI)是翻修全膝关节置换术(TKA)最常见的原因。最近的证据表明,全髋关节置换术后1年内发生PJI的患者在10年内死亡的风险显著增加。因此,本研究的目的是比较TKA指标后1年内发生PJI和未发生PJI患者的长期死亡率。方法采用回顾性人群水平数据库研究。所有符合条件的参与者都与单一付款人的公共医疗保健系统互动。主要结局指标是TKA指数后10年的死亡率;还比较了1年和5年死亡率。比较倾向评分匹配组的死亡率。结果在研究期间接受原发性TKA的263,204例患者(平均年龄和标准差为67.9±9.3岁)中,1,228例(0.5%)在1年内发生PJI。在整个样本中,TKA指数后1年内出现PJI的患者更有可能是男性,体弱多病,Charlson-Deyo评分为100 - 100;与1年内未发生PJI的患者相比,他们的充血性心力衰竭和慢性阻塞性肺疾病的发生率也明显更高。共有1202例患者在TKA指标1年内发生PJI, 1202例患者在TKA指标1年内未发生PJI,所有协变量的标准化差异均<0.10,表明匹配稳健。匹配后,第一年发生PJI的TKA受者10年死亡率显著高于前者(7.2% [86]vs . 1.6%[19]),绝对风险差= 5.45%[95%置信区间(CI) = 3.41% ~ 7.74%];风险比= 4.66 [95% CI = 2.84 ~ 7.66])。结论TKA后1年内发生PJI的患者在TKA后10年的死亡率明显高于TKA后1年内未发生PJI的患者。导致这种风险增加的病因尚不清楚,需要进一步调查,同时努力进一步预防、诊断和管理PJI。证据水平:治疗性三级。有关证据水平的完整描述,请参见作者说明。
{"title":"Periprosthetic Joint Infection Following Total Knee Arthroplasty Is Associated with a Significantly Elevated Risk of Mortality: A Population-Level Database Study.","authors":"Seper Ekhtiari,Raman Mundi,Daniel Pincus,Emil Schemitsch,J Michael Paterson,Harman Chaudhry,Jerome A Leis,Don Redelmeier,Bheeshma Ravi","doi":"10.2106/jbjs.25.00177","DOIUrl":"https://doi.org/10.2106/jbjs.25.00177","url":null,"abstract":"BACKGROUNDPeriprosthetic joint infection (PJI) is the most common reason for revision total knee arthroplasty (TKA). Recent evidence has demonstrated that patients who develop PJI within 1 year following total hip arthroplasty have a significantly elevated risk of mortality within 10 years. Thus, the aim of this study was to compare long-term mortality rates between patients who did and did not develop PJI within 1 year following the index TKA.METHODSThis was a retrospective population-level database study. All eligible participants interacted with a single-payer public health-care system. The primary outcome measure was mortality at 10 years following index TKA; 1- and 5-year mortality were also compared. Mortality was compared for propensity-score-matched groups.RESULTSOf the total of 263,204 patients who underwent primary TKA in the study period (mean age and standard deviation, 67.9 ± 9.3 years), 1,228 (0.5%) subsequently developed PJI within 1 year. Across the entire sample, patients who developed PJI within 1 year following the index TKA were more likely to be male, have frailty, and have a Charlson-Deyo score of >0; they also had significantly higher rates of congestive heart failure and chronic obstructive pulmonary disease compared with those who did not develop PJI within 1 year. A total of 1,202 patients who developed PJI within 1 year of the index TKA were matched to 1,202 patients who did not develop PJI within 1 year of the index TKA, with standardized differences of <0.10 for all covariates, indicating a robust match. After matching, TKA recipients who developed PJI in the first year had a significantly higher 10-year mortality rate (7.2% [86] versus 1.6% [19]; absolute risk difference = 5.45% [95% confidence interval (CI) = 3.41% to 7.74%]; hazard ratio = 4.66 [95% CI = 2.84 to 7.66]).CONCLUSIONSPatients who developed PJI within 1 year following TKA were at significantly higher risk for mortality at 10 years post-TKA compared with those who did not develop PJI within 1 year following TKA. The etiological factors leading to this increased risk remain unclear and warrant further investigation alongside efforts to further the prevention, diagnosis, and management of PJI.LEVEL OF EVIDENCETherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevascularized Bone Marrow-Derived Mesenchymal Stem Cell Sheets Promote Tendon-Bone Integration in Rotator Cuff Repair. 预血管化骨髓间充质干细胞片促进肌腱套修复中的肌腱-骨整合。
Pub Date : 2026-03-12 DOI: 10.2106/jbjs.25.01375
Yexin Li,Yang Chen,Yaxi Zhu,Ding Li,Lele Liao,Wanyun Li,Qian Liu
BACKGROUNDLimited vascularization at the tendon-bone interface (TBI) hinders rotator cuff (RC) healing. Although cell sheet technology has shown promise for interfacial repair, prevascularization strategies remain underexplored.METHODSTwenty female New Zealand rabbits underwent bilateral infraspinatus tendon repair and were randomized to receive either bone marrow-derived mesenchymal stem cell (BMSC) sheets or prevascularized BMSC sheets generated by coculture with endothelial cells, implanted at the TBI. An age- and weight-matched uninjured group served as a control. Healing at 6 weeks was assessed by gross observation, histology, immunohistochemistry, gene expression, and biomechanical testing.RESULTSPrevascularization of the BMSC sheets enhanced TBI vascularization, indicated by greater density of α-smooth muscle actin-positive vessels (16.16 ± 2.81 versus 10.63 ± 2.79/mm2, p = 0.0079). Immunohistochemistry demonstrated greater areas positive for collagen type II alpha 1 (86.96 ± 29.95 versus 40.25 ± 11.96 μm2, p = 0.0079) and interleukin 10 (14.93 ± 4.79 versus 7.43 ± 2.48 μm2, p = 0.0159). Biomechanically, prevascularization of the sheets yielded greater ultimate failure load (156.89 ± 51.92 versus 111.67 ± 27.51 N, p = 0.0364) and stiffness (37.27 ± 12.16 versus 27.16 ± 7.33 N/mm, p = 0.0486).CONCLUSIONSPrevascularization of BMSC sheets was able to promote angiogenesis and improve structural and mechanical aspects of tendon-bone healing.CLINICAL RELEVANCEPrevascularized BMSC sheets may represent a biologic adjunct to enhance tendon-bone healing in RC repair.
背景:肌腱-骨界面(TBI)有限的血管形成阻碍了肩袖(RC)的愈合。虽然细胞片技术已经显示出修复界面的希望,但预血管化策略仍未得到充分探索。方法20只雌性新西兰兔接受双侧棘下肌腱修复,随机分为骨髓间充质干细胞(BMSC)片和与内皮细胞共培养生成的预血管化BMSC片,植入创伤处。一个年龄和体重匹配的未受伤组作为对照。通过大体观察、组织学、免疫组织化学、基因表达和生物力学测试评估6周愈合情况。结果骨髓间充质干细胞片的血管扩张增强了TBI血管扩张,α-平滑肌肌动蛋白阳性血管密度增大(16.16±2.81比10.63±2.79/mm2, p = 0.0079)。免疫组化显示ⅱ型α - 1型胶原(86.96±29.95 vs 40.25±11.96 μm2, p = 0.0079)和白细胞介素10(14.93±4.79 vs 7.43±2.48 μm2, p = 0.0159)的阳性区域较大。从生物力学角度来看,预血管化的钢板产生更大的极限破坏载荷(156.89±51.92 N vs 111.67±27.51 N, p = 0.0364)和刚度(37.27±12.16 N/mm vs 27.16±7.33 N/mm, p = 0.0486)。结论骨髓间充质干细胞片的血管扩张能促进血管生成,改善肌腱-骨愈合的结构和力学方面。预血管化的骨髓间充质干细胞薄片可能是一种生物辅助物,可以增强肌腱-骨修复中的肌腱-骨愈合。
{"title":"Prevascularized Bone Marrow-Derived Mesenchymal Stem Cell Sheets Promote Tendon-Bone Integration in Rotator Cuff Repair.","authors":"Yexin Li,Yang Chen,Yaxi Zhu,Ding Li,Lele Liao,Wanyun Li,Qian Liu","doi":"10.2106/jbjs.25.01375","DOIUrl":"https://doi.org/10.2106/jbjs.25.01375","url":null,"abstract":"BACKGROUNDLimited vascularization at the tendon-bone interface (TBI) hinders rotator cuff (RC) healing. Although cell sheet technology has shown promise for interfacial repair, prevascularization strategies remain underexplored.METHODSTwenty female New Zealand rabbits underwent bilateral infraspinatus tendon repair and were randomized to receive either bone marrow-derived mesenchymal stem cell (BMSC) sheets or prevascularized BMSC sheets generated by coculture with endothelial cells, implanted at the TBI. An age- and weight-matched uninjured group served as a control. Healing at 6 weeks was assessed by gross observation, histology, immunohistochemistry, gene expression, and biomechanical testing.RESULTSPrevascularization of the BMSC sheets enhanced TBI vascularization, indicated by greater density of α-smooth muscle actin-positive vessels (16.16 ± 2.81 versus 10.63 ± 2.79/mm2, p = 0.0079). Immunohistochemistry demonstrated greater areas positive for collagen type II alpha 1 (86.96 ± 29.95 versus 40.25 ± 11.96 μm2, p = 0.0079) and interleukin 10 (14.93 ± 4.79 versus 7.43 ± 2.48 μm2, p = 0.0159). Biomechanically, prevascularization of the sheets yielded greater ultimate failure load (156.89 ± 51.92 versus 111.67 ± 27.51 N, p = 0.0364) and stiffness (37.27 ± 12.16 versus 27.16 ± 7.33 N/mm, p = 0.0486).CONCLUSIONSPrevascularization of BMSC sheets was able to promote angiogenesis and improve structural and mechanical aspects of tendon-bone healing.CLINICAL RELEVANCEPrevascularized BMSC sheets may represent a biologic adjunct to enhance tendon-bone healing in RC repair.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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The Journal of Bone & Joint Surgery
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