Leo Zalikha,Kuan-Lin Chen,Alexa K Pius,Marcel Sanchez,Isabella Zaniletti,James I Huddleston
BACKGROUNDThe U.S. Centers for Medicare & Medicaid Services (CMS) has set the substantial clinical benefit (SCB) for the Knee injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR) after primary total knee arthroplasty (TKA) at 20 points. We aimed to determine the percentages of patients who achieved the minimal clinically important difference (MCID) and the SCB for KOOS-JR at 1 year following TKA and to evaluate factors associated with benchmark achievement.METHODSWe queried the American Joint Replacement Registry (AJRR) and screened 1,284,404 primary TKA cases performed from 2018 to 2023. We determined attainment of the KOOS-JR distribution-based MCID (7.5), anchor-based MCID (14), and SCB (20) at 12 months by each patient. Associations of covariates with the achievement of the MCIDs and the SCB were evaluated using a generalized linear model for binary outcomes that accounted for clustering within institutions. Unadjusted and adjusted odds ratios (ORs) for the outcomes of interest with 95% confidence intervals (CIs) were reported. Covariates included the preoperative KOOS-JR, sex, race or ethnicity, body mass index (BMI), Charlson Comorbidity Index (CCI), fixation type, use of technology, year of the procedure, region, institution type, teaching status, and number of beds.RESULTSLinked scores were recorded by 64,773 patients. The mean patient age was 68.35 ± 8.60 years, 61.29% of patients were female, and 83.52% of patients were non-Hispanic White. The KOOS-JR threshold achievement rate was 86.8% for the calculated distribution-based MCID, 76.5% for the anchor-based MCID, and 65.7% for the SCB. Patients with higher preoperative scores (adjusted OR, 0.93 [95% CI, 0.93 to 0.93]; p < 0.001), Asian patients (adjusted OR, 0.59 [95% CI, 0.46 to 0.74]; p < 0.001), Black patients (adjusted OR, 0.55 [95% CI, 0.49 to 0.62]; p < 0.001), Hispanic patients (adjusted OR, 0.71 [95% CI, 0.51 to 0.99]; p = 0.042), non-Hispanic patients of other races (adjusted OR, 0.84 [95% CI, 0.74 to 0.95]; p = 0.007), male patients (adjusted OR, 0.89 [95% CI, 0.85 to 0.94]; p < 0.001), and patients with higher BMI (adjusted OR, 0.93 [95% CI, 0.87 to 0.99]; p = 0.025) showed lower odds of achieving the SCB. A CCI of ≥5 was additionally found to be associated with lower odds of achieving the distribution-based MCID (adjusted OR, 0.89 [95% CI, 0.79 to 0.99]; p = 0.032) and anchor-based MCID (adjusted OR, 0.89 [95% CI, 0.81 to 0.97]; p = 0.012).CONCLUSIONSThe CMS relatively arbitrarily defined the SCB at a value that is too high for an operation that routinely yields >80% patient satisfaction.LEVEL OF EVIDENCEPrognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
{"title":"Substantial Clinical Benefit After Total Knee Arthroplasty Has Been Set Too High: An Analysis of the American Joint Replacement Registry.","authors":"Leo Zalikha,Kuan-Lin Chen,Alexa K Pius,Marcel Sanchez,Isabella Zaniletti,James I Huddleston","doi":"10.2106/jbjs.25.00952","DOIUrl":"https://doi.org/10.2106/jbjs.25.00952","url":null,"abstract":"BACKGROUNDThe U.S. Centers for Medicare & Medicaid Services (CMS) has set the substantial clinical benefit (SCB) for the Knee injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR) after primary total knee arthroplasty (TKA) at 20 points. We aimed to determine the percentages of patients who achieved the minimal clinically important difference (MCID) and the SCB for KOOS-JR at 1 year following TKA and to evaluate factors associated with benchmark achievement.METHODSWe queried the American Joint Replacement Registry (AJRR) and screened 1,284,404 primary TKA cases performed from 2018 to 2023. We determined attainment of the KOOS-JR distribution-based MCID (7.5), anchor-based MCID (14), and SCB (20) at 12 months by each patient. Associations of covariates with the achievement of the MCIDs and the SCB were evaluated using a generalized linear model for binary outcomes that accounted for clustering within institutions. Unadjusted and adjusted odds ratios (ORs) for the outcomes of interest with 95% confidence intervals (CIs) were reported. Covariates included the preoperative KOOS-JR, sex, race or ethnicity, body mass index (BMI), Charlson Comorbidity Index (CCI), fixation type, use of technology, year of the procedure, region, institution type, teaching status, and number of beds.RESULTSLinked scores were recorded by 64,773 patients. The mean patient age was 68.35 ± 8.60 years, 61.29% of patients were female, and 83.52% of patients were non-Hispanic White. The KOOS-JR threshold achievement rate was 86.8% for the calculated distribution-based MCID, 76.5% for the anchor-based MCID, and 65.7% for the SCB. Patients with higher preoperative scores (adjusted OR, 0.93 [95% CI, 0.93 to 0.93]; p < 0.001), Asian patients (adjusted OR, 0.59 [95% CI, 0.46 to 0.74]; p < 0.001), Black patients (adjusted OR, 0.55 [95% CI, 0.49 to 0.62]; p < 0.001), Hispanic patients (adjusted OR, 0.71 [95% CI, 0.51 to 0.99]; p = 0.042), non-Hispanic patients of other races (adjusted OR, 0.84 [95% CI, 0.74 to 0.95]; p = 0.007), male patients (adjusted OR, 0.89 [95% CI, 0.85 to 0.94]; p < 0.001), and patients with higher BMI (adjusted OR, 0.93 [95% CI, 0.87 to 0.99]; p = 0.025) showed lower odds of achieving the SCB. A CCI of ≥5 was additionally found to be associated with lower odds of achieving the distribution-based MCID (adjusted OR, 0.89 [95% CI, 0.79 to 0.99]; p = 0.032) and anchor-based MCID (adjusted OR, 0.89 [95% CI, 0.81 to 0.97]; p = 0.012).CONCLUSIONSThe CMS relatively arbitrarily defined the SCB at a value that is too high for an operation that routinely yields >80% patient satisfaction.LEVEL OF EVIDENCEPrognostic Level II. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josef E Jolissaint,Katherine E Mallett,Andrew L Thomson,Alberto V Carli,Matthew S Austin
BACKGROUNDCefazolin, a first-generation cephalosporin, is the standard antibiotic for perioperative prophylaxis in patients undergoing hip or knee arthroplasty. Research has demonstrated significantly higher periprosthetic joint infection (PJI) rates when non-cefazolin antibiotics are used for prophylaxis. Notably, cefazolin contains an R1 side chain that has not shown cross-reactivity with other cephalosporins. However, in patients with a reported cephalosporin allergy, there is often uncertainty about the optimal antibiotic choice. This study aimed to determine the safety of perioperative cefazolin in patients with a documented cephalosporin allergy undergoing joint arthroplasty.METHODSWe reviewed the records of 1,268 patients who had a documented cephalosporin allergy and underwent total hip or knee arthroplasty at a high-volume academic center from 2016 to 2024. We compared patients who received cefazolin despite a cephalosporin allergy (n = 482) and patients who received an alternative antibiotic prophylaxis (n = 786). The primary outcome was the incidence of immunoglobulin E (IgE)-mediated allergic reactions or "severe" Type-IV delayed hypersensitivity reactions with end organ dysfunction within 72 hours postoperatively. The secondary outcomes included 90-day rates of complications including PJI, Clostridioides difficile infections, adverse events related to the antibiotic, and readmission.RESULTSThe incidence of an allergic reaction in patients with an allergy to cephalosporin who received cefazolin was 0.0% (0 of 482) compared with 0.51% (4 of 786) in patients who received an alternative antibiotic prophylaxis (p = 0.30). There were no significant differences in the rates of PJI after primary arthroplasty (0.21% compared with 0.26%; p = 0.83), C. difficile infection (0.0% compared with 0.0%), or readmission within 90 days (3.95% compared with 4.33%; p = 0.75). One patient who received cefazolin experienced mild, self-limited urethral irritation. Five patients receiving alternative antibiotics experienced antibiotic-related adverse events, including skin reactions, gastrointestinal distress, pancreatitis, and headache.CONCLUSIONSIn this cohort of patients undergoing joint arthroplasty, cefazolin administration in patients with a cephalosporin allergy was associated with a 0.0% incidence of IgE-mediated or severe Type-IV allergic reactions.LEVEL OF EVIDENCETherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
{"title":"Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty.","authors":"Josef E Jolissaint,Katherine E Mallett,Andrew L Thomson,Alberto V Carli,Matthew S Austin","doi":"10.2106/jbjs.25.01349","DOIUrl":"https://doi.org/10.2106/jbjs.25.01349","url":null,"abstract":"BACKGROUNDCefazolin, a first-generation cephalosporin, is the standard antibiotic for perioperative prophylaxis in patients undergoing hip or knee arthroplasty. Research has demonstrated significantly higher periprosthetic joint infection (PJI) rates when non-cefazolin antibiotics are used for prophylaxis. Notably, cefazolin contains an R1 side chain that has not shown cross-reactivity with other cephalosporins. However, in patients with a reported cephalosporin allergy, there is often uncertainty about the optimal antibiotic choice. This study aimed to determine the safety of perioperative cefazolin in patients with a documented cephalosporin allergy undergoing joint arthroplasty.METHODSWe reviewed the records of 1,268 patients who had a documented cephalosporin allergy and underwent total hip or knee arthroplasty at a high-volume academic center from 2016 to 2024. We compared patients who received cefazolin despite a cephalosporin allergy (n = 482) and patients who received an alternative antibiotic prophylaxis (n = 786). The primary outcome was the incidence of immunoglobulin E (IgE)-mediated allergic reactions or \"severe\" Type-IV delayed hypersensitivity reactions with end organ dysfunction within 72 hours postoperatively. The secondary outcomes included 90-day rates of complications including PJI, Clostridioides difficile infections, adverse events related to the antibiotic, and readmission.RESULTSThe incidence of an allergic reaction in patients with an allergy to cephalosporin who received cefazolin was 0.0% (0 of 482) compared with 0.51% (4 of 786) in patients who received an alternative antibiotic prophylaxis (p = 0.30). There were no significant differences in the rates of PJI after primary arthroplasty (0.21% compared with 0.26%; p = 0.83), C. difficile infection (0.0% compared with 0.0%), or readmission within 90 days (3.95% compared with 4.33%; p = 0.75). One patient who received cefazolin experienced mild, self-limited urethral irritation. Five patients receiving alternative antibiotics experienced antibiotic-related adverse events, including skin reactions, gastrointestinal distress, pancreatitis, and headache.CONCLUSIONSIn this cohort of patients undergoing joint arthroplasty, cefazolin administration in patients with a cephalosporin allergy was associated with a 0.0% incidence of IgE-mediated or severe Type-IV allergic reactions.LEVEL OF EVIDENCETherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew L Thomson,Christina Chao,Mohammad Hammad,Mario Mendia,Mathias P G Bostrom,Alberto V Carli
BACKGROUNDRetained polymethylmethacrylate (PMMA) in surgical instrument trays and on instruments is becoming more common and is a disquieting situation for the arthroplasty operating room team. Although retained debris may be sterile after autoclaving, previous studies have not specifically investigated bacterial viability on retained PMMA. This study determined whether heavily contaminated PMMA surfaces and instruments covered in PMMA could be effectively sterilized by clinically utilized autoclaving protocols.METHODSMature methicillin-susceptible Staphylococcus aureus (MSSA) and Escherichia coli biofilms were grown on PMMA coupons with a smooth surface (n = 5 per condition) or with deep crevices (n = 5 per condition) and on threaded screws, which were inserted into polymerizing PMMA (n = 5 per condition). PMMA coupons and PMMA-covered screws were subjected to 3 autoclave sterilization protocols. Colony-forming unit (CFU) counts and adenosine triphosphate (ATP) levels were measured to detect viable bacteria. Scanning electron microscope (SEM) images were obtained to determine whether biofilm was present.RESULTSNon-autoclaved PMMA surfaces were heavily contaminated, with values of 4.1 ± 2.3 × 106 CFUs/mL for S. aureus and 2.4 ± 1.2 × 106 CFUs/mL for E. coli. ATP levels of 3,230 ± 1,297 relative light units (RLU) for S. aureus and 1,006 ± 602 RLU for E. coli were observed. Crevices and screws were also heavily contaminated. Following autoclaving, CFUs/mL counts of <10 and RLU levels of <5 (beneath the hygienic threshold for cleanliness) were recorded on all PMMA surfaces, crevices, and screws. SEM confirmed that the biofilm structures remained intact, but they did not contain viable bacteria.CONCLUSIONSPMMA and PMMA-covered instruments contaminated with gram-positive or gram-negative biofilms are effectively sterilized using clinical autoclaving protocols.CLINICAL RELEVANCERetained PMMA and PMMA-covered surgical instruments that undergo a clinical autoclaving protocol do not carry viable bacteria.
{"title":"Autoclaving Effectively Sterilizes Contaminated Retained Cement in Orthopaedic Surgical Trays.","authors":"Andrew L Thomson,Christina Chao,Mohammad Hammad,Mario Mendia,Mathias P G Bostrom,Alberto V Carli","doi":"10.2106/jbjs.25.00655","DOIUrl":"https://doi.org/10.2106/jbjs.25.00655","url":null,"abstract":"BACKGROUNDRetained polymethylmethacrylate (PMMA) in surgical instrument trays and on instruments is becoming more common and is a disquieting situation for the arthroplasty operating room team. Although retained debris may be sterile after autoclaving, previous studies have not specifically investigated bacterial viability on retained PMMA. This study determined whether heavily contaminated PMMA surfaces and instruments covered in PMMA could be effectively sterilized by clinically utilized autoclaving protocols.METHODSMature methicillin-susceptible Staphylococcus aureus (MSSA) and Escherichia coli biofilms were grown on PMMA coupons with a smooth surface (n = 5 per condition) or with deep crevices (n = 5 per condition) and on threaded screws, which were inserted into polymerizing PMMA (n = 5 per condition). PMMA coupons and PMMA-covered screws were subjected to 3 autoclave sterilization protocols. Colony-forming unit (CFU) counts and adenosine triphosphate (ATP) levels were measured to detect viable bacteria. Scanning electron microscope (SEM) images were obtained to determine whether biofilm was present.RESULTSNon-autoclaved PMMA surfaces were heavily contaminated, with values of 4.1 ± 2.3 × 106 CFUs/mL for S. aureus and 2.4 ± 1.2 × 106 CFUs/mL for E. coli. ATP levels of 3,230 ± 1,297 relative light units (RLU) for S. aureus and 1,006 ± 602 RLU for E. coli were observed. Crevices and screws were also heavily contaminated. Following autoclaving, CFUs/mL counts of <10 and RLU levels of <5 (beneath the hygienic threshold for cleanliness) were recorded on all PMMA surfaces, crevices, and screws. SEM confirmed that the biofilm structures remained intact, but they did not contain viable bacteria.CONCLUSIONSPMMA and PMMA-covered instruments contaminated with gram-positive or gram-negative biofilms are effectively sterilized using clinical autoclaving protocols.CLINICAL RELEVANCERetained PMMA and PMMA-covered surgical instruments that undergo a clinical autoclaving protocol do not carry viable bacteria.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Complex Origins of Expectations in TKA: Commentary on an article by Carol A. Mancuso, MD, et al.: \"Sources of Patients' Expectations of Total Knee Arthroplasty\".","authors":"Cody C Wyles","doi":"10.2106/jbjs.25.01096","DOIUrl":"https://doi.org/10.2106/jbjs.25.01096","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"6 1","pages":"79-80"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.2106/jbjs.er.24.00248
Tomoyuki Kamenaga,Kenichi Kikuchi,Regis J O'Keefe,John C Clohisy,Cecilia Pascual-Garrido
{"title":"Erratum: Experimentally Induced Femoroacetabular Impingement Results in Hip Osteoarthritis.","authors":"Tomoyuki Kamenaga,Kenichi Kikuchi,Regis J O'Keefe,John C Clohisy,Cecilia Pascual-Garrido","doi":"10.2106/jbjs.er.24.00248","DOIUrl":"https://doi.org/10.2106/jbjs.er.24.00248","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"266 1","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antioxidant-Loaded Highly Cross-Linked Polyethylene in Total Knee Arthroplasty: The Need for Radiostereometric Randomized Controlled Trials: Commentary on an article by Heather A. Prentice, PhD, et al.: \"Antioxidant-Loaded Highly Cross-Linked Polyethylene May Reduce Revision Risk in Total Knee Arthroplasty. A U.S.-Based Cohort Study\".","authors":"B G Pijls","doi":"10.2106/jbjs.25.01312","DOIUrl":"https://doi.org/10.2106/jbjs.25.01312","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"65 1","pages":"81-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of Contiguous-Joint Arthritis After Pilon Fracture: Commentary on an article by Raveena Joshi, BS, et al.: \"The Prevalence of Subtalar Arthritis Following Pilon Fractures\".","authors":"Sheldon S Lin","doi":"10.2106/jbjs.25.01361","DOIUrl":"https://doi.org/10.2106/jbjs.25.01361","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"48 1","pages":"75-76"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Should a Course of Oral Corticosteroids Be Used Routinely After TKA?: Commentary on an article by Supakit Kanitnate, MD, et al.: \"Oral Corticosteroids Reduce Pain After Total Knee Arthroplasty: A Higher Dose of Dexamethasone Effectively Controlled Pain During Motion. A Dose-Response Randomized Placebo-Controlled Trial\".","authors":"Elizabeth B Gausden,Brian P Chalmers","doi":"10.2106/jbjs.25.01083","DOIUrl":"https://doi.org/10.2106/jbjs.25.01083","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"187 1","pages":"77-78"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
治疗性IV级。参见作者说明获得证据级别的完整描述。
{"title":"Assessment of Custom-Made Acetabular Implants for Complex Revision Total Hip Arthroplasty: A Concise Follow-up, at a Minimum of 5 Years.","authors":"Anna Di Laura,Johann Henckel,Alister Hart","doi":"10.2106/jbjs.25.00876","DOIUrl":"https://doi.org/10.2106/jbjs.25.00876","url":null,"abstract":"Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bryan Yijia Tan,Julia Poh Hwee Ng,Lincoln Ming Han Liow,Wei Seong Toh,Michael Gui Jie Yam,Joyce Bee Suang Koh,James Hui Po Hui
Orthopaedic surgeons are the custodians of the musculoskeletal system in Singapore, with >350 orthopaedic surgeons looking after the whole continuum of musculoskeletal disease in a population of 6 million. Orthopaedic research in Singapore currently has 4 focus areas: tissue engineering, biomechanics, clinical registries and cohorts, and population health and health services research. We have identified 4 key enablers of the continued development of orthopaedic research: talent development and academic clinical programs; shared data infrastructure, national cohorts, and artificial intelligence; innovation; and interdisciplinary, industry, and international collaboration. This is an exciting time for orthopaedic research in Singapore, where we find ourselves at the cusp of a new wave of talent, ideas, and resources. We stand ready and excited to partner with the world to advance musculoskeletal care globally.
{"title":"Orthopaedic Research in Singapore: The Past, Present, and Future.","authors":"Bryan Yijia Tan,Julia Poh Hwee Ng,Lincoln Ming Han Liow,Wei Seong Toh,Michael Gui Jie Yam,Joyce Bee Suang Koh,James Hui Po Hui","doi":"10.2106/jbjs.25.01276","DOIUrl":"https://doi.org/10.2106/jbjs.25.01276","url":null,"abstract":"Orthopaedic surgeons are the custodians of the musculoskeletal system in Singapore, with >350 orthopaedic surgeons looking after the whole continuum of musculoskeletal disease in a population of 6 million. Orthopaedic research in Singapore currently has 4 focus areas: tissue engineering, biomechanics, clinical registries and cohorts, and population health and health services research. We have identified 4 key enablers of the continued development of orthopaedic research: talent development and academic clinical programs; shared data infrastructure, national cohorts, and artificial intelligence; innovation; and interdisciplinary, industry, and international collaboration. This is an exciting time for orthopaedic research in Singapore, where we find ourselves at the cusp of a new wave of talent, ideas, and resources. We stand ready and excited to partner with the world to advance musculoskeletal care globally.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"397 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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