Ginsenoside Rc prevents dexamethasone-induced muscle atrophy and enhances muscle strength and motor function

IF 6.8 2区 医学 Q1 CHEMISTRY, MEDICINAL Journal of Ginseng Research Pub Date : 2024-09-11 DOI:10.1016/j.jgr.2024.09.002
Aeyung Kim, Sang-Min Park, No Soo Kim, Musun Park, Seongwon Cha
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Abstract

A decline in muscle mass and function can impact the health, disease vulnerability, and mortality of older adults. Prolonged use of high doses of glucocorticoids, such as dexamethasone (DEX), can cause muscle wasting and reduced strength. Ginsenoside Rc (gRc) has been shown to protect muscles by activating the PGC-1α pathway and improving mitochondrial function. The effects of gRc on muscle atrophy and function in mice are not fully understood. The study discovered that gRc prevented the DEX-induced decrease in viability of C2C12 myoblasts and myotubes. Furthermore, gRc inhibited myotube degradation and the upregulation of muscle degradation proteins induced by DEX. Transcriptome analysis of myotubes showed that gRc enhances muscle generation processes while suppressing the TGF-β pathway and oxidative stress response. In mice, gRc effectively reversed the reductions in body weight, muscle mass, and muscle fibers caused by DEX. Furthermore, gRc significantly enhanced muscle strength and exercise capacity. Docking and transcriptome analyses indicated that gRc may act as a competitive inhibitor of DEX at the glucocorticoid receptor, potentially preventing muscle loss. The study suggests that gRc can prevent DEX-induced muscle wasting and weakness. Consequently, it may be a viable treatment option for sarcopenia and muscle-related disorders in various medical conditions.
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人参皂苷 Rc 可防止地塞米松诱发的肌肉萎缩,增强肌肉力量和运动功能
肌肉质量和功能的下降会影响老年人的健康、疾病易感性和死亡率。长期使用大剂量糖皮质激素,如地塞米松(DEX),会导致肌肉萎缩和力量下降。研究表明,人参皂苷 Rc(gRc)可通过激活 PGC-1α 通路和改善线粒体功能来保护肌肉。目前还不完全清楚人参皂苷 Rc 对小鼠肌肉萎缩和功能的影响。研究发现,gRc能防止DEX诱导的C2C12成肌细胞和肌管活力下降。此外,gRc还能抑制DEX诱导的肌管降解和肌肉降解蛋白的上调。肌细胞的转录组分析表明,gRc在抑制TGF-β途径和氧化应激反应的同时,还能增强肌肉的生成过程。在小鼠体内,gRc能有效逆转DEX导致的体重、肌肉质量和肌肉纤维的减少。此外,gRc 还能明显增强肌肉力量和运动能力。对接和转录组分析表明,gRc可能是DEX在糖皮质激素受体上的竞争性抑制剂,有可能防止肌肉流失。这项研究表明,gRc 可以防止 DEX 引起的肌肉萎缩和虚弱。因此,它可能是治疗各种病症中肌肉疏松症和肌肉相关疾病的一种可行方法。
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来源期刊
Journal of Ginseng Research
Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE
CiteScore
11.40
自引率
9.50%
发文量
111
审稿时长
6-12 weeks
期刊介绍: Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.
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