Based on Medicine, The Now and Future of Large Language Models

IF 2.3 4区 医学 Q3 BIOPHYSICS Cellular and molecular bioengineering Pub Date : 2024-09-16 DOI:10.1007/s12195-024-00820-3
Ziqing Su, Guozhang Tang, Rui Huang, Yang Qiao, Zheng Zhang, Xingliang Dai
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Abstract

Objectives

This review explores the potential applications of large language models (LLMs) such as ChatGPT, GPT-3.5, and GPT-4 in the medical field, aiming to encourage their prudent use, provide professional support, and develop accessible medical AI tools that adhere to healthcare standards.

Methods

This paper examines the impact of technologies such as OpenAI's Generative Pre-trained Transformers (GPT) series, including GPT-3.5 and GPT-4, and other large language models (LLMs) in medical education, scientific research, clinical practice, and nursing. Specifically, it includes supporting curriculum design, acting as personalized learning assistants, creating standardized simulated patient scenarios in education; assisting with writing papers, data analysis, and optimizing experimental designs in scientific research; aiding in medical imaging analysis, decision-making, patient education, and communication in clinical practice; and reducing repetitive tasks, promoting personalized care and self-care, providing psychological support, and enhancing management efficiency in nursing.

Results

LLMs, including ChatGPT, have demonstrated significant potential and effectiveness in the aforementioned areas, yet their deployment in healthcare settings is fraught with ethical complexities, potential lack of empathy, and risks of biased responses.

Conclusion

Despite these challenges, significant medical advancements can be expected through the proper use of LLMs and appropriate policy guidance. Future research should focus on overcoming these barriers to ensure the effective and ethical application of LLMs in the medical field.

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基于医学,大型语言模型的现状与未来
目的本综述探讨了大型语言模型(LLM)(如 ChatGPT、GPT-3.5 和 GPT-4 等)在医疗领域的潜在应用,旨在鼓励谨慎使用这些模型,提供专业支持,并开发符合医疗保健标准的可访问的医疗人工智能工具。方法本文研究了 OpenAI 的生成预训练转换器(GPT)系列(包括 GPT-3.5 和 GPT-4)和其他大型语言模型(LLM)等技术在医学教育、科学研究、临床实践和护理方面的影响。具体来说,包括在教育领域支持课程设计、充当个性化学习助手、创建标准化模拟病人情景;在科研领域协助撰写论文、分析数据、优化实验设计;在临床实践领域协助医学影像分析、决策、病人教育和沟通;在护理领域减少重复性工作、促进个性化护理和自我护理、提供心理支持、提高管理效率。结果包括 ChatGPT 在内的 LLMs 在上述领域表现出了巨大的潜力和有效性,然而在医疗环境中应用 LLMs 却充满了复杂的伦理问题、可能缺乏同理心以及有偏差反应的风险。未来的研究应侧重于克服这些障碍,以确保在医疗领域有效、合乎道德地应用 LLM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.60
自引率
3.60%
发文量
30
审稿时长
>12 weeks
期刊介绍: The field of cellular and molecular bioengineering seeks to understand, so that we may ultimately control, the mechanical, chemical, and electrical processes of the cell. A key challenge in improving human health is to understand how cellular behavior arises from molecular-level interactions. CMBE, an official journal of the Biomedical Engineering Society, publishes original research and review papers in the following seven general areas: Molecular: DNA-protein/RNA-protein interactions, protein folding and function, protein-protein and receptor-ligand interactions, lipids, polysaccharides, molecular motors, and the biophysics of macromolecules that function as therapeutics or engineered matrices, for example. Cellular: Studies of how cells sense physicochemical events surrounding and within cells, and how cells transduce these events into biological responses. Specific cell processes of interest include cell growth, differentiation, migration, signal transduction, protein secretion and transport, gene expression and regulation, and cell-matrix interactions. Mechanobiology: The mechanical properties of cells and biomolecules, cellular/molecular force generation and adhesion, the response of cells to their mechanical microenvironment, and mechanotransduction in response to various physical forces such as fluid shear stress. Nanomedicine: The engineering of nanoparticles for advanced drug delivery and molecular imaging applications, with particular focus on the interaction of such particles with living cells. Also, the application of nanostructured materials to control the behavior of cells and biomolecules.
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