Cardiovascular health, measured using Life's Essential 8, is associated with reduced dementia risk among older men and women

IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Journal of the American Geriatrics Society Pub Date : 2024-09-18 DOI:10.1111/jgs.19194
Xin Li, Yichen Jin, Stefania Bandinelli, Luigi Ferrucci, Toshiko Tanaka, Sameera A. Talegawkar
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Abstract

BackgroundDementia poses considerable challenges to healthy aging. Prevention and management of dementia are essential given the lack of effective treatments for this condition.MethodsA secondary data analysis was conducted using data from 928 InCHIANTI study participants (55% female) aged 65 years and older without dementia at baseline. Cardiovascular health (CVH) was assessed by the “Life's Essential 8” (LE8) metric that included health behaviors (diet, physical activity, smoking status, sleep duration) and health factors (body mass index, blood lipid, blood glucose, blood pressure). This new LE8 metric scores from 0 to 100, with categorization including “low LE8” (0–49), indicating low CVH, “moderate LE8 (50‐79)”, indicating moderate CVH, and “high LE8 (80‐100)”, indicating high CVH. Dementia was ascertained by a combination of neuropsychological testing and clinical assessment at each follow‐up visit. Cox proportional hazards models were used to examine associations between CVH at baseline and risk of incident dementia after a median follow‐up of 14 years.ResultsBetter CVH (moderate/high LE8 vs. low LE8) was inversely associated with the risk of incident dementia (hazard ratio [HR]: 0.61, 95% confidence interval [CI]: 0.46–0.83, p = 0.001). Compared with health factors, higher scores of the health behaviors (per 1 standard deviation [SD]), specifically weekly moderate‐to‐vigorous physical activity time (per 1 SD), were significantly associated with a lower risk of incident dementia (health behaviors: HR:0.84, CI:0.73–0.96, p = 0.01; physical activity: HR: 0.62, CI: 0.53–0.72, p < 0.001).ConclusionWhile longitudinal studies with repeated measures of CVH are needed to confirm these findings, improving CVH, measured by the LE8 metric, may be a promising dementia prevention strategy.
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使用 "生命必备 8 项指标 "衡量心血管健康状况,可降低老年男性和女性患痴呆症的风险
背景痴呆症给健康老龄化带来了巨大挑战。方法利用 928 名 InCHIANTI 研究参与者(55% 为女性)的数据进行了二次数据分析,这些参与者年龄在 65 岁及以上,基线时未患有痴呆症。心血管健康(CVH)通过 "生命必需 8"(LE8)指标进行评估,该指标包括健康行为(饮食、体力活动、吸烟状况、睡眠时间)和健康因素(体重指数、血脂、血糖、血压)。这一新的 LE8 指标从 0 到 100 分,分类包括 "低 LE8"(0-49 分),表示低 CVH;"中 LE8(50-79 分)",表示中度 CVH;"高 LE8(80-100 分)",表示高度 CVH。在每次随访时,通过神经心理学测试和临床评估相结合的方法确定痴呆程度。结果较好的CVH(中度/高度LE8与低度LE8)与痴呆症发病风险成反比(危险比[HR]:0.61,95%置信区间[CI]:0.46-0.83,P = 0.001)。与健康因素相比,较高的健康行为得分(每 1 个标准差 [SD]),特别是每周中强度体育活动时间(每 1 个标准差),与较低的痴呆症发病风险显著相关(健康行为:HR:0.84,CI:0.73-0.96,P = 0.01;体育活动:结论虽然还需要对 CVH 进行重复测量的纵向研究来证实这些发现,但通过 LE8 指标来改善 CVH 可能是一种很有前景的痴呆症预防策略。
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来源期刊
CiteScore
10.00
自引率
6.30%
发文量
504
审稿时长
3-6 weeks
期刊介绍: Journal of the American Geriatrics Society (JAGS) is the go-to journal for clinical aging research. We provide a diverse, interprofessional community of healthcare professionals with the latest insights on geriatrics education, clinical practice, and public policy—all supporting the high-quality, person-centered care essential to our well-being as we age. Since the publication of our first edition in 1953, JAGS has remained one of the oldest and most impactful journals dedicated exclusively to gerontology and geriatrics.
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