{"title":"A base-promoted synthesis of 3,4-dihydro-2(1H)-quinazolinones","authors":"Rui Xiong, Yadi Liu, Fang-Lin Zhang","doi":"10.1515/znb-2024-0045","DOIUrl":null,"url":null,"abstract":"A convenient and concise base-promoted synthesis of 3,4-dihydro-2(1<jats:italic>H</jats:italic>)-quinazolinones and multi-membered cyclic ureas has been developed. In the presence of <jats:italic>t</jats:italic>BuOK, a variety of 3,4-dihydro-2(1<jats:italic>H</jats:italic>)-quinazolinones as well as the <jats:italic>N</jats:italic>-arylated five-, six- and nine-membered cyclic ureas were readily synthesized under mild conditions. This method offers an alternative synthesis toolkit towards cyclic ureas.","PeriodicalId":23831,"journal":{"name":"Zeitschrift für Naturforschung B","volume":"187 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Naturforschung B","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/znb-2024-0045","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A convenient and concise base-promoted synthesis of 3,4-dihydro-2(1H)-quinazolinones and multi-membered cyclic ureas has been developed. In the presence of tBuOK, a variety of 3,4-dihydro-2(1H)-quinazolinones as well as the N-arylated five-, six- and nine-membered cyclic ureas were readily synthesized under mild conditions. This method offers an alternative synthesis toolkit towards cyclic ureas.
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