Rhodium(III)‐Catalyzed (5 + 2) Annulation Reaction for the Synthesis of Nitro and Cyano Substituted Benzo[b]oxepines

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-09-17 DOI:10.1002/ajoc.202400392

Deep J. Kalita, Pratiksha Bhorali, Supriya Khundrakpam, Sanjib Gogoi

引用次数: 0

Abstract

A Rh(III)‐catalyzed annulation reaction of 2‐(2‐nitrovinyl)phenols and disubstituted alkynes is developed to complete the first synthesis of biologically important 4‐nitro substituted benzo[b]oxepines. The same reaction conditions are also applied for the efficient synthesis of 4‐cyano substituted benzo[b]oxepines which have high biological significance. Some of the synthesized 4‐nitrobenzo[b]oxepines are easily transformed to triazole fused dibenzo[b]oxepines.

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铑（III）催化 (5 + 2) 嵌合反应合成硝基和氰基取代的苯并[b]氧杂卓

通过 Rh(III) 催化的 2-(2-硝基乙烯基)苯酚与二取代炔的环化反应，首次合成了具有重要生物学意义的 4-硝基取代的苯并[b]氧杂卓。同样的反应条件也用于高效合成具有重要生物学意义的 4-氰基取代的苯并[b]氧杂卓。合成的一些 4-硝基苯并[b]氧杂卓很容易转化为三唑融合二苯并[b]氧杂卓。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.