Two New Isoindole Alkaloids from Aspergillus fumigatus as Potential Activators for Tobacco Powdery Mildew

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL Chemistry of Natural Compounds Pub Date : 2024-09-18 DOI:10.1007/s10600-024-04469-2

Yu-Ping Wu, Hua-Yin Liu, Wen-Yu Liu, Gao-Kun Zhao, Guang-Hai Zhang, Heng Yao, Wei Li, Wei-Guang Wang, Guang-Hui Kong, Bo Yang

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Abstract

To further explore powdery mildew (caused by Golovinomyces cichoracearum) natural products, an extract from the fermentation of endophytic Aspergillus fumigatus was investigated. As a result, six isoindole alkaloid derivatives (1–6) were isolated. Among them, two compounds (1 and 2) were newly discovered and the activity evaluation of the purified compounds 1–6 against G. cichoracearum was studied. The results revealed that compounds 1–6 demonstrated obvious anti-G. cichoracearum activities for cigar tobacco in the range of 40.6% ± 5.4 to 66.5% ± 4.9 at a concentration of 250 μg/mL, respectively. However, these rates are lower than that of positive control. By isolating and structurally identifying the above isoindole alkaloids, new materials conducive to improving the utilization of N. tabacum-derived fungi could be developed for screening anti-powdery mildew drugs.

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来自烟曲霉的两种新的异吲哚生物碱是烟草白粉病的潜在激活剂

为了进一步探索白粉病（由 Golovinomyces cichoracearum 引起）的天然产物，研究人员从内生曲霉（Aspergillus fumigatus）的发酵中提取了一种提取物。结果分离出六种异吲哚生物碱衍生物（1-6）。其中两个化合物（1 和 2）是新发现的，研究了纯化的化合物 1-6 对 G. cichoracearum 的活性评价。结果表明，化合物 1-6 对雪茄烟中的 G. cichoracearum 具有明显的抗活性，浓度为 250 μg/mL 时，抗活性范围分别为 40.6% ± 5.4 至 66.5% ± 4.9。不过，这些比率低于阳性对照。通过对上述异吲哚生物碱的分离和结构鉴定，可以开发出有利于提高N. tabacum衍生真菌利用率的新材料，用于筛选抗白粉病药物。

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.