Integration of texture analysis based on DCE-MRI Ktrans map and metabolomics of early bone marrow microvascular changes in alloxan-induced diabetic rabbits

IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BMC Medical Imaging Pub Date : 2024-09-16 DOI:10.1186/s12880-024-01416-z
Yan Wang, Liang Li, Yuchen Yan, Tian Zhang, Lei Hu, Jun Chen, Yunfei Zha
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Abstract

To evaluate early bone marrow microvascular changes in alloxan-induced diabetic rabbits using IDEAL-IQ fat quantification, texture analysis based on DCE-MRI Ktrans map, and metabolomics. 24 male Japanese rabbits were randomly divided into diabetic (n = 12) and control (n = 12) groups. All rabbits underwent sagittal MRI of the lumbar vertebrae at the 0th,4th, 8th, 12th, and 16th week, respectively. The fat fraction (FF) ratio and quantitative permeability of the lumbar bone marrow was measured. Texture parameters were extracted from DCE-MRI Ktrans map. At 16th week, lumbar vertebrae 5 and 6 were used for histological analysis. Lumbar vertebra 7 was crushed to obtain bone marrow for metabolomics research. The FF ratio and Ktrans of the lumbar bone marrow in diabetic group were increased significantly at 16th week (t = 2.226, P = 0.02; Z = -2.721, P < 0.01). Nine texture feature parameters based on DCE-MRI Ktrans map were significantly different between the groups at the 16th week (all P < 0.05). Pathway analysis showed that diabetic bone marrow microvascular changes were mainly related to linoleic acid metabolism. Differential metabolites were correlated with the number of adipocytes, FF ratio, and permeability parameters. The integration of metabolomics with texture analysis based on DCE-MRI Ktrans map may be used to evaluate diabetic bone marrow microvascular changes at an early stage. It remains to be validated in clinical studies whether the integration of metabolomics with texture analysis based on the DCE-MRI Ktrans map can effectively evaluate diabetic bone marrow.
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基于 DCE-MRI Ktrans 图谱的纹理分析与代谢组学对阿脲诱导糖尿病兔骨髓微血管早期变化的整合研究
利用 IDEAL-IQ 脂肪定量、基于 DCE-MRI Ktrans 图的纹理分析和代谢组学评估阿脲诱导的糖尿病兔的早期骨髓微血管变化。24 只雄性日本兔被随机分为糖尿病组(12 只)和对照组(12 只)。所有兔子分别在第 0 周、第 4 周、第 8 周、第 12 周和第 16 周接受腰椎矢状面核磁共振成像检查。测量了腰椎骨髓的脂肪率(FF)和定量渗透性。纹理参数是从 DCE-MRI Ktrans 图中提取的。第16周时,对腰椎5和6进行组织学分析。腰椎7被粉碎以获取骨髓用于代谢组学研究。第16周时,糖尿病组腰椎骨髓的FF比值和Ktrans显著增加(t = 2.226,P = 0.02;Z = -2.721,P < 0.01)。第16周时,基于DCE-MRI Ktrans图的9个纹理特征参数在组间存在明显差异(P均<0.05)。通路分析表明,糖尿病骨髓微血管变化主要与亚油酸代谢有关。差异代谢物与脂肪细胞数量、FF比率和通透性参数相关。代谢组学与基于DCE-MRI Ktrans图的纹理分析相结合,可用于早期评估糖尿病骨髓微血管的变化。基于DCE-MRI Ktrans图的代谢组学与纹理分析的整合能否有效评估糖尿病骨髓,还有待临床研究验证。
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来源期刊
BMC Medical Imaging
BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
4.60
自引率
3.70%
发文量
198
审稿时长
27 weeks
期刊介绍: BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.
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