Preparation of magnetic scaffolds via supercritical carbon dioxide foaming process using iron oxide nanoparticles coated with CO2‐philic materials as nucleating agents

IF 2.7 3区 化学 Q2 POLYMER SCIENCE Journal of Applied Polymer Science Pub Date : 2024-09-17 DOI:10.1002/app.56256
Zhen Jiao, Shuo Zhang, Jinjing Wang, Yi Zhang
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Abstract

The iron oxide nanoparticles (IONs), coated with different materials, are synthesized and utilized as nucleating agents to prepare magnetic multi‐modal porous scaffolds of poly (lactic‐co‐glycolic acid)/IONs using the supercritical carbon dioxide (ScCO2) foaming process. The effects of the modification materials, including citric acid, polycaprolactone, and polyvinyl acetate, on the foaming process and properties of the magnetic scaffolds are systematically investigated. The results indicate that the solubility and diffusion ability of CO2 in the foaming materials played a vital role in the foaming process. The use of CO2‐philic materials and high pressure proves beneficial in generating micropores. The scaffolds with multi‐modal porous structures can be obtained at relatively low pressure for the ScCO2 foaming systems evaluated in this study. Furthermore, the prepared scaffolds exhibit high porosity and a good compressive modulus (higher than 0.4 MPa), satisfying the requirements of tissue engineering for soft tissue scaffolds.

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使用涂有亲二氧化碳材料的氧化铁纳米颗粒作为成核剂,通过超临界二氧化碳发泡工艺制备磁性支架
利用超临界二氧化碳(ScCO2)发泡工艺,合成了包覆不同材料的氧化铁纳米粒子(IONs),并将其作为成核剂用于制备聚(乳酸-共聚乙醇酸)/IONs 的磁性多模多孔支架。系统研究了柠檬酸、聚己内酯和聚醋酸乙烯等改性材料对发泡过程和磁性支架性能的影响。结果表明,二氧化碳在发泡材料中的溶解度和扩散能力对发泡过程起着至关重要的作用。亲二氧化碳材料和高压的使用有利于产生微孔。在本研究评估的 ScCO2 发泡系统中,可以在相对较低的压力下获得具有多模多孔结构的支架。此外,制备的支架具有高孔隙率和良好的压缩模量(高于 0.4 兆帕),满足了组织工程对软组织支架的要求。
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来源期刊
Journal of Applied Polymer Science
Journal of Applied Polymer Science 化学-高分子科学
CiteScore
5.70
自引率
10.00%
发文量
1280
审稿时长
2.7 months
期刊介绍: The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.
期刊最新文献
Editorial Board, Aims & Scope, Table of Contents Editorial Board, Aims & Scope, Table of Contents Editorial Board, Aims & Scope, Table of Contents Editorial Board, Aims & Scope, Table of Contents Cover Image, Volume 141, Issue 43
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