Value of measuring markers of lipid metabolism in horses during an oral glucose test

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES Journal of Veterinary Internal Medicine Pub Date : 2024-09-18 DOI:10.1111/jvim.17199

Claire H. K. Zemek, Kate L. Kemp, François-René Bertin

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Abstract

Background

Characterizing the lipid response to an oral glucose test (OGT) might improve our understanding of Equine Metabolic Syndrome.

Hypothesis/Objectives

To describe the effects of an OGT on lipid metabolism and determine the value of measuring triglyceride and nonesterified fatty acid (NEFA) concentrations in hyperinsulinemic (HI) and insulin-resistant (IR) horses.

Animals

Twenty horses including 7 HI-IR horses, 4 HI-non-IR horses, and 9 non-HI-non-IR horses (control).

Methods

Cross-sectional design. Horses underwent an OGT, with blood samples collected at 0, 60, 90, and 120 minutes. Insulin, glucose, triglyceride, and NEFA concentrations were measured and compared over time and between groups, with P < .05 considered significant.

Results

In all horses, the OGT had a significant effect on triglyceride concentrations (median [interquartile range]: .35 [.30-.50] mmol/L at 0 minute vs .25 [.21-.37] mmol/L at 120 minutes, P = .005) and on NEFA concentrations (.1 [.1-.2] mEq/L at 0 minute vs .05 [.05-.1] mEq/L at 120 minutes, P = .0009). However, horses with HI and IR had higher triglyceride areas under the curve (AUC, 79.46 ± 46.59 vs 33.32 ± 6.75 mmol/L*min, P = .01) as well as NEFA AUC (9.1 ± 2.9 vs 6.0 ± 6.8 mEq/L*min, P = .03) than control horses. No significant difference was detected between control and HI non-IR horses.

Conclusions and Clinical Importance

Determining triglyceride and NEFA concentrations might help assess tissue insulin resistance during an OGT.

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在口服葡萄糖测试期间测量马匹脂质代谢指标的价值

背景描述口服葡萄糖试验（OGT）对脂质代谢的影响，并确定测量高胰岛素血症（HI）和胰岛素抵抗（IR）马体内甘油三酯和非酯化脂肪酸（NEFA）浓度的价值。动物20匹马，包括7匹HI-IR马、4匹HI-非IR马和9匹非HI-非IR马（对照组）。马匹接受 OGT，分别在 0、60、90 和 120 分钟采集血样。测量胰岛素、葡萄糖、甘油三酯和 NEFA 的浓度，并在不同时间和不同组间进行比较，以 P < .05 为显著性。结果在所有马匹中，OGT 对甘油三酯浓度有显著影响（中位数 [四分位间范围]：...[.....]）。0 分钟时为 35 [.30-.50] mmol/L vs 120 分钟时为 .25 [.21-.37] mmol/L，P = .005）和 NEFA 浓度（0 分钟时为 0.1 [.1-.2] mEq/L vs 120 分钟时为 0.05 [.05-.1] mEq/L，P = .0009）。然而，HI 和 IR 马匹的甘油三酯曲线下面积（AUC，79.46 ± 46.59 vs 33.32 ± 6.75 mmol/L*min，P = .01）和 NEFA AUC（9.1 ± 2.9 vs 6.0 ± 6.8 mEq/L*min，P = .03）均高于对照组马匹。结论和临床意义确定甘油三酯和 NEFA 的浓度可能有助于评估 OGT 期间的组织胰岛素抵抗。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.