An efficient synthesis of pyrano [2, 3-d] pyrimidines catalyzed by ZrO2-CeO2 nanoparticles and their anticancer evaluation

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of the Iranian Chemical Society Pub Date : 2024-09-13 DOI:10.1007/s13738-024-03097-5
Aarti Nagar, Virendra Singh Meena, Pradeep Kumar Paliwal, Shubha Jain
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Abstract

Zirconium doped cerium nanoparticles have been found to be an excellent heterogeneous catalyst for the one-pot multi-component reactions of Barbituric acid, aromatic aldehyde and malononitrile to yield the Pyrano(2,3-d) pyrimidine derivatives in aqueous media. The results showed that nanosized CeO2 − ZrO2 has a potential catalytic material for the synthesis of title compound. All the synthesized molecules were determined and characterised by chromatographic and spectroscopic (IR,1H-NMR, 13C-NMR, HR-MS) analysis. The formation, size and morphology of the metal ions present in the material is confirmed by powdered X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques. The synthesised compounds have shown good to excellent cytotoxicity against human breast cancer cell line MDA-MB-453.

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ZrO2-CeO2 纳米粒子催化的吡喃 [2, 3-d] 嘧啶的高效合成及其抗癌评估
研究发现,掺锆铈纳米粒子是一种优良的异相催化剂,可在水介质中通过巴比妥酸、芳香醛和丙二腈的一锅多组分反应生成吡喃(2,3-d)嘧啶衍生物。结果表明,纳米级 CeO2 - ZrO2 是合成标题化合物的潜在催化材料。所有合成的分子都通过色谱和光谱(红外光谱、1H-NMR、13C-NMR、HR-MS)分析进行了测定和表征。粉末 X 射线衍射(XRD)、扫描电子显微镜(SEM)和透射电子显微镜(TEM)技术证实了材料中金属离子的形成、大小和形态。合成的化合物对人类乳腺癌细胞系 MDA-MB-453 具有良好至卓越的细胞毒性。
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来源期刊
CiteScore
4.40
自引率
8.30%
发文量
230
审稿时长
5.6 months
期刊介绍: JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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