HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression

IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Genes & Diseases Pub Date : 2024-09-12 DOI:10.1016/j.gendis.2024.101433
Jiacheng Zhong, Shuang Shi, Wen Peng, Hongjuan Cui, Xiaochuan Sun
{"title":"HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression","authors":"Jiacheng Zhong, Shuang Shi, Wen Peng, Hongjuan Cui, Xiaochuan Sun","doi":"10.1016/j.gendis.2024.101433","DOIUrl":null,"url":null,"abstract":"Gliomas represent the most common primary malignant intracranial tumors in adults. Despite recent advances in treatment, the prognosis of patients with glioblastoma remains poor. Epigenetic abnormalities, the hallmarks of various types of cancer, contribute to the dysregulated expression of cancer-related genes. Post-translational modification of histones plays a pivotal role in cancer development and progression by modulating gene transcription, chromatin remodeling, and nuclear structure. Therefore, further exploration of the molecular mechanisms of epigenetic regulation in gliomas and the identification of superior therapeutic targets are required. High-mobility group nucleosomal-binding domain 2 (HMGN2) participates in the epigenetic regulation of genes through histone modification and exhibits significant differential expression between glioma and normal tissues. However, the effect of HMGN2 on gliomas and its underlying mechanisms remain unclear. This study aimed to elucidate these uncertainties by demonstrating that HMGN2 significantly promotes the proliferation of glioma cells. HMGN2 binds to histones and promotes the stability of H3K27ac acetylation in the cell division cycle 20 (CDC20) promoter region, enhancing the transcriptional activity of CDC20 and increasing the proliferation of glioma cells. Moreover, we found that CDC20 expression was negatively correlated with the survival time of patients with glioma. These results suggest that targeting epigenetic regulation, such as the HMGN2/CDC20 axis, may provide a novel direction for the treatment of gliomas.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":null,"pages":null},"PeriodicalIF":6.9000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes & Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.gendis.2024.101433","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Gliomas represent the most common primary malignant intracranial tumors in adults. Despite recent advances in treatment, the prognosis of patients with glioblastoma remains poor. Epigenetic abnormalities, the hallmarks of various types of cancer, contribute to the dysregulated expression of cancer-related genes. Post-translational modification of histones plays a pivotal role in cancer development and progression by modulating gene transcription, chromatin remodeling, and nuclear structure. Therefore, further exploration of the molecular mechanisms of epigenetic regulation in gliomas and the identification of superior therapeutic targets are required. High-mobility group nucleosomal-binding domain 2 (HMGN2) participates in the epigenetic regulation of genes through histone modification and exhibits significant differential expression between glioma and normal tissues. However, the effect of HMGN2 on gliomas and its underlying mechanisms remain unclear. This study aimed to elucidate these uncertainties by demonstrating that HMGN2 significantly promotes the proliferation of glioma cells. HMGN2 binds to histones and promotes the stability of H3K27ac acetylation in the cell division cycle 20 (CDC20) promoter region, enhancing the transcriptional activity of CDC20 and increasing the proliferation of glioma cells. Moreover, we found that CDC20 expression was negatively correlated with the survival time of patients with glioma. These results suggest that targeting epigenetic regulation, such as the HMGN2/CDC20 axis, may provide a novel direction for the treatment of gliomas.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
HMGN2 通过调控 CDC20 的表达加速胶质母细胞瘤的增殖和细胞周期进程
胶质瘤是成人最常见的原发性颅内恶性肿瘤。尽管最近在治疗方面取得了进展,但胶质母细胞瘤患者的预后仍然很差。表观遗传异常是各种癌症的标志,它导致癌症相关基因表达失调。组蛋白的翻译后修饰通过调节基因转录、染色质重塑和核结构,在癌症的发生和发展过程中起着举足轻重的作用。因此,需要进一步探索胶质瘤中表观遗传调控的分子机制,并确定优良的治疗靶点。高迁移率基团核糖体结合域 2(HMGN2)通过组蛋白修饰参与基因的表观遗传调控,并在胶质瘤和正常组织之间表现出显著的表达差异。然而,HMGN2 对胶质瘤的影响及其内在机制仍不清楚。本研究旨在通过证明 HMGN2 能显著促进胶质瘤细胞的增殖来阐明这些不确定性。HMGN2与组蛋白结合,促进细胞分裂周期20(CDC20)启动子区H3K27ac乙酰化的稳定性,增强CDC20的转录活性,增加胶质瘤细胞的增殖。此外,我们还发现 CDC20 的表达与胶质瘤患者的生存时间呈负相关。这些结果表明,以HMGN2/CDC20轴等表观遗传调控为靶点,可能为胶质瘤的治疗提供一个新的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Genes & Diseases
Genes & Diseases Multiple-
CiteScore
7.30
自引率
0.00%
发文量
347
审稿时长
49 days
期刊介绍: Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.
期刊最新文献
Targeting MYC: Multidimensional regulation and therapeutic strategies in oncology Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation MAFB-mediated CEBPA regulated human urothelium growth through Wnt/β-catenin signaling pathway HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression Systematic pan-cancer analysis identifies DNASE2 as a potential prognostic marker and immunotherapeutic target for glioblastoma multiforme
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1