Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes

IF 14.3 1区 医学 Q1 ONCOLOGY Trends in cancer Pub Date : 2024-09-14 DOI:10.1016/j.trecan.2024.08.005
Benjamin N. Gantner, Flavio R. Palma, Madhura R. Pandkar, Marcelo J. Sakiyama, Daniel Arango, Gina M. DeNicola, Ana P. Gomes, Marcelo G. Bonini
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Abstract

Emerging evidence indicates that metabolism not only is a source of energy and biomaterials for cell division but also acts as a driver of cancer cell plasticity and treatment resistance. This is because metabolic changes lead to remodeling of chromatin and reprogramming of gene expression patterns, furthering tumor cell phenotypic transitions. Therefore, the crosstalk between metabolism and epigenetics seems to hold immense potential for the discovery of novel therapeutic targets for various aggressive tumors. Here, we highlight recent discoveries supporting the concept that the cooperation between metabolism and epigenetics enables cancer to overcome mounting treatment-induced pressures. We discuss how specific metabolites contribute to cancer cell resilience and provide perspective on how simultaneously targeting these key forces could produce synergistic therapeutic effects to improve treatment outcomes.

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代谢和表观遗传学:肿瘤细胞可塑性和治疗效果的驱动因素
新的证据表明,新陈代谢不仅是细胞分裂的能量和生物材料来源,而且还是癌细胞可塑性和耐药性的驱动因素。这是因为新陈代谢的变化会导致染色质的重塑和基因表达模式的重编程,进一步推动肿瘤细胞表型的转变。因此,新陈代谢与表观遗传学之间的相互影响似乎蕴含着发现各种侵袭性肿瘤的新型治疗靶点的巨大潜力。在此,我们重点介绍最近的发现,这些发现支持了这样一个概念,即代谢和表观遗传学之间的合作使癌症能够克服日益增加的治疗压力。我们讨论了特定的代谢物如何促进癌细胞的恢复能力,并透视了同时针对这些关键力量如何产生协同治疗效果以改善治疗效果。
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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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