Impact of Glaucomatous Ganglion Cell Damage on Central Visual Function

IF 5 2区 医学 Q1 NEUROSCIENCES Annual Review of Vision Science Pub Date : 2024-09-18 DOI:10.1146/annurev-vision-110223-123044
MiYoung Kwon
{"title":"Impact of Glaucomatous Ganglion Cell Damage on Central Visual Function","authors":"MiYoung Kwon","doi":"10.1146/annurev-vision-110223-123044","DOIUrl":null,"url":null,"abstract":"Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs) and subsequent visual field defects. RGCs, as the final output neurons of the retina, perform key computations underpinning human pattern vision, such as contrast coding. Conventionally, glaucoma has been associated with peripheral vision loss, and thus, relatively little attention has been paid to deficits in central vision. However, recent advancements in retinal imaging techniques have significantly bolstered research into glaucomatous damage of the macula, revealing that it is prevalent even in the early stages of glaucoma. Thus, it is an opportune time to explore how glaucomatous damage undermines the perceptual processes associated with central visual function. This review showcases recent studies addressing central dysfunction in the early and moderate stages of glaucoma. It further emphasizes the need to characterize glaucomatous damage in both central and peripheral vision, as they jointly affect an individual's everyday activities.","PeriodicalId":48658,"journal":{"name":"Annual Review of Vision Science","volume":"26 1","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Vision Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-vision-110223-123044","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs) and subsequent visual field defects. RGCs, as the final output neurons of the retina, perform key computations underpinning human pattern vision, such as contrast coding. Conventionally, glaucoma has been associated with peripheral vision loss, and thus, relatively little attention has been paid to deficits in central vision. However, recent advancements in retinal imaging techniques have significantly bolstered research into glaucomatous damage of the macula, revealing that it is prevalent even in the early stages of glaucoma. Thus, it is an opportune time to explore how glaucomatous damage undermines the perceptual processes associated with central visual function. This review showcases recent studies addressing central dysfunction in the early and moderate stages of glaucoma. It further emphasizes the need to characterize glaucomatous damage in both central and peripheral vision, as they jointly affect an individual's everyday activities.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
青光眼神经节细胞损伤对中枢视觉功能的影响
青光眼是导致不可逆失明的主要原因,其特征是视网膜神经节细胞(RGC)的逐渐丧失和随之而来的视野缺损。视网膜神经节细胞作为视网膜的最终输出神经元,执行着人类模式视觉的关键计算,如对比度编码。传统上,青光眼与周边视力丧失有关,因此对中心视力缺陷的关注相对较少。然而,最近视网膜成像技术的进步极大地促进了对黄斑部青光眼损害的研究,揭示出即使在青光眼的早期阶段,黄斑部青光眼损害也很普遍。因此,现在正是探讨青光眼损害如何破坏与中枢视觉功能相关的知觉过程的大好时机。本综述展示了针对青光眼早期和中度阶段中枢功能障碍的最新研究。它进一步强调了描述青光眼对中心和周边视觉的损害的必要性,因为它们共同影响着一个人的日常活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Annual Review of Vision Science
Annual Review of Vision Science Medicine-Ophthalmology
CiteScore
11.10
自引率
1.70%
发文量
19
期刊介绍: The Annual Review of Vision Science reviews progress in the visual sciences, a cross-cutting set of disciplines which intersect psychology, neuroscience, computer science, cell biology and genetics, and clinical medicine. The journal covers a broad range of topics and techniques, including optics, retina, central visual processing, visual perception, eye movements, visual development, vision models, computer vision, and the mechanisms of visual disease, dysfunction, and sight restoration. The study of vision is central to progress in many areas of science, and this new journal will explore and expose the connections that link it to biology, behavior, computation, engineering, and medicine.
期刊最新文献
Informing Endpoints for Clinical Trials of Geographic Atrophy Retinal Connectomics: A Review Impact of Glaucomatous Ganglion Cell Damage on Central Visual Function Digital Image Sensor Evolution and New Frontiers Cellular and Molecular Mechanisms Regulating Retinal Synapse Development
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1