Impact of Glaucomatous Ganglion Cell Damage on Central Visual Function

IF 5 2区 医学 Q1 NEUROSCIENCES Annual Review of Vision Science Pub Date : 2024-09-18 DOI:10.1146/annurev-vision-110223-123044
MiYoung Kwon
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Abstract

Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs) and subsequent visual field defects. RGCs, as the final output neurons of the retina, perform key computations underpinning human pattern vision, such as contrast coding. Conventionally, glaucoma has been associated with peripheral vision loss, and thus, relatively little attention has been paid to deficits in central vision. However, recent advancements in retinal imaging techniques have significantly bolstered research into glaucomatous damage of the macula, revealing that it is prevalent even in the early stages of glaucoma. Thus, it is an opportune time to explore how glaucomatous damage undermines the perceptual processes associated with central visual function. This review showcases recent studies addressing central dysfunction in the early and moderate stages of glaucoma. It further emphasizes the need to characterize glaucomatous damage in both central and peripheral vision, as they jointly affect an individual's everyday activities.
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青光眼神经节细胞损伤对中枢视觉功能的影响
青光眼是导致不可逆失明的主要原因,其特征是视网膜神经节细胞(RGC)的逐渐丧失和随之而来的视野缺损。视网膜神经节细胞作为视网膜的最终输出神经元,执行着人类模式视觉的关键计算,如对比度编码。传统上,青光眼与周边视力丧失有关,因此对中心视力缺陷的关注相对较少。然而,最近视网膜成像技术的进步极大地促进了对黄斑部青光眼损害的研究,揭示出即使在青光眼的早期阶段,黄斑部青光眼损害也很普遍。因此,现在正是探讨青光眼损害如何破坏与中枢视觉功能相关的知觉过程的大好时机。本综述展示了针对青光眼早期和中度阶段中枢功能障碍的最新研究。它进一步强调了描述青光眼对中心和周边视觉的损害的必要性,因为它们共同影响着一个人的日常活动。
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来源期刊
Annual Review of Vision Science
Annual Review of Vision Science Medicine-Ophthalmology
CiteScore
11.10
自引率
1.70%
发文量
19
期刊介绍: The Annual Review of Vision Science reviews progress in the visual sciences, a cross-cutting set of disciplines which intersect psychology, neuroscience, computer science, cell biology and genetics, and clinical medicine. The journal covers a broad range of topics and techniques, including optics, retina, central visual processing, visual perception, eye movements, visual development, vision models, computer vision, and the mechanisms of visual disease, dysfunction, and sight restoration. The study of vision is central to progress in many areas of science, and this new journal will explore and expose the connections that link it to biology, behavior, computation, engineering, and medicine.
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