Influenza A-associated acute necrotising encephalopathy

IF 2.4 Q2 CLINICAL NEUROLOGY PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI:10.1136/pn-2024-004249
Hawraman Ramadan, Ibrahim Hassan, Reham Elgafy, Souhel Najjar
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Abstract

A previously healthy woman in her 20s was brought to the emergency department with a convulsive seizure. Over the preceding 24 hours, she had developed flu-like symptoms, including cough, headache and fever (39°C). She was started on lorazepam with a loading dose of levetiracetam and given empirical intravenous acyclovir and ceftriaxone. A CT scan of the head and blood tests for inflammatory markers, full blood count and renal and liver profile were normal. She was intubated and admitted to the medical intensive care unit due to a persistently low Glasgow coma scale score (7–8) and recurrent seizures. Cerebrospinal fluid (CSF) examination showed two white cells/µL (≤5), glucose 4.06 mmol/L (2.5–4.4) and protein 0.96 g/L (0.15–0.45); Gram stain, culture, viral PCR panel and cytology were negative. Electroencephalogram showed severe diffuse theta-delta slowing consistent with encephalopathy. A nasopharyngeal swab tested positive for influenza A, H3N2 subtype. Blood and …
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甲型流感相关急性坏死性脑病
急诊科接诊了一名 20 多岁的健康女性,她因抽搐而被送往急诊科。在之前的 24 小时内,她出现了类似流感的症状,包括咳嗽、头痛和发烧(39°C)。医生开始给她服用劳拉西泮和负荷剂量的左乙拉西坦,并给她静脉注射阿昔洛韦和头孢曲松。头部 CT 扫描以及炎症指标、全血细胞计数、肝肾功能检查均正常。由于格拉斯哥昏迷量表评分持续较低(7-8分)且反复发作,她被插管并送入内科重症监护室。脑脊液(CSF)检查显示白细胞为2个/微升(≤5),葡萄糖为4.06毫摩尔/升(2.5-4.4),蛋白质为0.96克/升(0.15-0.45);革兰氏染色、培养、病毒PCR检测和细胞学检查均为阴性。脑电图显示与脑病一致的严重弥漫性θ-δ减慢。鼻咽拭子检测结果呈甲型 H3N2 亚型流感阳性。血液和...
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来源期刊
PRACTICAL NEUROLOGY
PRACTICAL NEUROLOGY Medicine-Neurology (clinical)
CiteScore
3.70
自引率
3.60%
发文量
113
期刊介绍: The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.
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