{"title":"Call for Papers: Academic and Industrial Collaborations in Drug Discovery","authors":"Danielle Schultz, Eric Voight, Stevan W. Djuric","doi":"10.1021/acsmedchemlett.4c00435","DOIUrl":null,"url":null,"abstract":"Dear Colleagues, Given the considerable interest generated from our Virtual Special Issues on the topic of enabling chemistry technologies in drug discovery, (1,2) the Editorial Board at <i>ACS Medicinal Chemistry Letters</i> has decided to broaden this approach to include the positive impact of academic and industrial collaborations on the drug discovery process. The suggestions listed below for topics that can be covered represent only the tip of the iceberg. The subject matter may include development of new synthetic methodology/total synthesis in terms of applications to medicinal chemistry and chemical biology, as well as potential challenges at the intersection of total synthesis, biology, and medicine; the development of new synthetic methodology to produce better routes to drug candidates; or building blocks for parallel synthesis work or novel fragments for fragment-based drug discovery purposes. This could include photoredox chemistry or catalyst development, high-throughput experimentation-enabled reaction optimization, or chemistry techniques for DNA-encoded library production and screening. We will also include efforts in chemical proteomics, whether it be targeting identification proteomics or off-target profiling; research to identify and validate new targets using chemical probes, including novel photoaffinity probes; and novel and improved analytical methods (e.g., reduction of analysis time, impact of novel MS-based methods). We are open to other hot topic areas such as antibody–drug candidates, targeted protein degradation/molecular glues, small-molecule RNA regulation, and therapeutic area initiatives such as the prevention and treatment of tropical diseases. This research may be done, for example, through sponsored research collaborations or, alternatively, student internships. We look forward to receiving your submissions! Sincerely, The Editorial Team at <i>ACS Medicinal Chemistry Letters</i> <i>ACS Medicinal Chemistry Letters</i> encourages submissions of Letters, Notes, Technical Notes, Microperspectives, and Viewpoints highlighting the importance of academic and industrial collaborations. Submit your manuscript via ACS Paragon Plus and select “Academic and Industrial Collaborations in Drug Discovery” from the Special Issue dropdown box. Submissions will undergo the normal peer-review process and, and if accepted, will be published on a rolling basis. Once the Virtual Special Issue is complete, all articles will be publicized as a virtual collection, which will provide additional exposure for the work. The submission deadline is May 31, 2025. Please consider the Author Guidelines before submitting a manuscript. We welcome presubmission inquiries, which can be sent to eic@medchemlett.acs.org This article references 2 other publications. This article has not yet been cited by other publications.","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Medicinal Chemistry Letters","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1021/acsmedchemlett.4c00435","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Dear Colleagues, Given the considerable interest generated from our Virtual Special Issues on the topic of enabling chemistry technologies in drug discovery, (1,2) the Editorial Board at ACS Medicinal Chemistry Letters has decided to broaden this approach to include the positive impact of academic and industrial collaborations on the drug discovery process. The suggestions listed below for topics that can be covered represent only the tip of the iceberg. The subject matter may include development of new synthetic methodology/total synthesis in terms of applications to medicinal chemistry and chemical biology, as well as potential challenges at the intersection of total synthesis, biology, and medicine; the development of new synthetic methodology to produce better routes to drug candidates; or building blocks for parallel synthesis work or novel fragments for fragment-based drug discovery purposes. This could include photoredox chemistry or catalyst development, high-throughput experimentation-enabled reaction optimization, or chemistry techniques for DNA-encoded library production and screening. We will also include efforts in chemical proteomics, whether it be targeting identification proteomics or off-target profiling; research to identify and validate new targets using chemical probes, including novel photoaffinity probes; and novel and improved analytical methods (e.g., reduction of analysis time, impact of novel MS-based methods). We are open to other hot topic areas such as antibody–drug candidates, targeted protein degradation/molecular glues, small-molecule RNA regulation, and therapeutic area initiatives such as the prevention and treatment of tropical diseases. This research may be done, for example, through sponsored research collaborations or, alternatively, student internships. We look forward to receiving your submissions! Sincerely, The Editorial Team at ACS Medicinal Chemistry LettersACS Medicinal Chemistry Letters encourages submissions of Letters, Notes, Technical Notes, Microperspectives, and Viewpoints highlighting the importance of academic and industrial collaborations. Submit your manuscript via ACS Paragon Plus and select “Academic and Industrial Collaborations in Drug Discovery” from the Special Issue dropdown box. Submissions will undergo the normal peer-review process and, and if accepted, will be published on a rolling basis. Once the Virtual Special Issue is complete, all articles will be publicized as a virtual collection, which will provide additional exposure for the work. The submission deadline is May 31, 2025. Please consider the Author Guidelines before submitting a manuscript. We welcome presubmission inquiries, which can be sent to eic@medchemlett.acs.org This article references 2 other publications. This article has not yet been cited by other publications.
期刊介绍:
ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to:
Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)
Biological characterization of new molecular entities in the context of drug discovery
Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.
Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry
Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources
Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response
Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic
Mechanistic drug metabolism and regulation of metabolic enzyme gene expression
Chemistry patents relevant to the medicinal chemistry field.