Pub Date : 2024-06-13DOI: 10.1021/acsmedchemlett.4c00130
Ethan J. Pazur, Anna Kalatanova, N. Tasker, Katri Vainionpää, Henri Leinonen, Peter Wipf
{"title":"Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration","authors":"Ethan J. Pazur, Anna Kalatanova, N. Tasker, Katri Vainionpää, Henri Leinonen, Peter Wipf","doi":"10.1021/acsmedchemlett.4c00130","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00130","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141346511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.1021/acsmedchemlett.4c00030
Toru Taniguchi, Isao Yasumatsu, Hiroaki Inagaki, Daichi Baba, Akiko Toyota, Yasuyuki Kaneta, T. Odagiri, Takayuki Momose, J. Kawai, T. Imaoka, Kiyoshi Nakayama
{"title":"Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581","authors":"Toru Taniguchi, Isao Yasumatsu, Hiroaki Inagaki, Daichi Baba, Akiko Toyota, Yasuyuki Kaneta, T. Odagiri, Takayuki Momose, J. Kawai, T. Imaoka, Kiyoshi Nakayama","doi":"10.1021/acsmedchemlett.4c00030","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00030","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141346227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-12DOI: 10.1021/acsmedchemlett.4c00211
Rebecca Knight, Laura E. Kilpatrick, Stephen J. Hill, Michael J. Stocks
{"title":"Design, Synthesis, and Evaluation of a New Chemotype Fluorescent Ligand for the P2Y2 Receptor","authors":"Rebecca Knight, Laura E. Kilpatrick, Stephen J. Hill, Michael J. Stocks","doi":"10.1021/acsmedchemlett.4c00211","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00211","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.1021/acsmedchemlett.4c00215
Chelsea R. Jones, Grant H. Lai, Maria Sophia Teresa Lee Padilla, J. Nowick
{"title":"Investigation of Isobactin Analogues of Teixobactin","authors":"Chelsea R. Jones, Grant H. Lai, Maria Sophia Teresa Lee Padilla, J. Nowick","doi":"10.1021/acsmedchemlett.4c00215","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00215","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141358836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.1021/acsmedchemlett.3c00453
G. Collie, U. Börjesson, Yunhua Chen, Zhiqiang Dong, Paolo Di Fruscia, Andrea Gohlke, Anna Hoyle, Thomas A. Hunt, M. Jesani, Haiou Luo, Jakub Luptak, Alexander G. Milbradt, Priyanka Narasimhan, Martin J. Packer, Saleha Patel, Jingchuan Qiao, R. Storer, Christopher J. Stubbs, Jonathan Tart, C. Truman, Anderson T. Wang, Matthew G. Wheeler, J. Winter-Holt
{"title":"Fragment-Based Discovery of Novel MUS81 Inhibitors","authors":"G. Collie, U. Börjesson, Yunhua Chen, Zhiqiang Dong, Paolo Di Fruscia, Andrea Gohlke, Anna Hoyle, Thomas A. Hunt, M. Jesani, Haiou Luo, Jakub Luptak, Alexander G. Milbradt, Priyanka Narasimhan, Martin J. Packer, Saleha Patel, Jingchuan Qiao, R. Storer, Christopher J. Stubbs, Jonathan Tart, C. Truman, Anderson T. Wang, Matthew G. Wheeler, J. Winter-Holt","doi":"10.1021/acsmedchemlett.3c00453","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.3c00453","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.1021/acsmedchemlett.4c00111
George Fytas, Grigoris Zoidis, Antonios Drakopoulos, Martin C. Taylor, John M. Kelly, Alexandra Tsatsaroni, A. Tsotinis
{"title":"New Lipophilic Hydroxamates as Promising Trypanocidal Agents: Design, Synthesis, SAR, and Conformational Behavior Studies","authors":"George Fytas, Grigoris Zoidis, Antonios Drakopoulos, Martin C. Taylor, John M. Kelly, Alexandra Tsatsaroni, A. Tsotinis","doi":"10.1021/acsmedchemlett.4c00111","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00111","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.1021/acsmedchemlett.4c00148
Ruhi Choudhary, R. Mahadevan
{"title":"FOCUS on NOD2: Advancing IBD Drug Discovery with a User-Informed Machine Learning Framework","authors":"Ruhi Choudhary, R. Mahadevan","doi":"10.1021/acsmedchemlett.4c00148","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00148","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141377670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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