Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review

IF 4.7 3区 工程技术 Q2 ENGINEERING, ENVIRONMENTAL Journal of Polymers and the Environment Pub Date : 2024-09-17 DOI:10.1007/s10924-024-03398-z
Parinaz Nezhad-Mokhtari, Reza Rahbarghazi, Hamed Hamishehkar, Peyman Asadi, Morteza Milani
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Abstract

Multifunctional nanocomposite scaffolds, particularly those incorporating zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs), are emerging as effective solutions for skin and tissue injuries due to their biocompatibility, structural stability, and antibacterial properties. Integrating ZIF-8 NPs into polymeric scaffolds has significant potential for improved tissue regeneration. This review examines recent advancements in ZIF-8 NP-integrated scaffolds, including their applications in nanofibers, hydrogels, microneedles, and 3D-printable scaffolds. It details the synthesis methods, structural characteristics, and physicochemical properties of ZIF-8 NPs, highlighting their role in enhancing wound healing. The methodological basis of ZIF-8 in wound healing applications involves its synthesis and functionalization to enhance biocompatibility, enabling the creation of drug delivery systems that release bioactive agents in a controlled manner to promote tissue regeneration and accelerate wound healing. This review highlights the biocompatibility and biosafety of ZIF-8 NPs, noting their non-toxic nature within specific concentration ranges and their multifunctional capabilities, such as antibacterial and anti-inflammatory effects that facilitate angiogenesis and infection management. The review also addresses current challenges and future perspectives in developing and clinically translating ZIF-8-based nanocomposite scaffolds as next-generation materials for improving wound healing.

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用于改善伤口愈合的含 ZIF-8 纳米粒子的创新型纳米复合支架:综述
多功能纳米复合材料支架,尤其是含有沸石咪唑框架-8 纳米粒子(ZIF-8 NPs)的支架,因其生物相容性、结构稳定性和抗菌特性,正在成为治疗皮肤和组织损伤的有效解决方案。将 ZIF-8 NPs 集成到聚合物支架中具有改善组织再生的巨大潜力。本综述探讨了 ZIF-8 NP 集成支架的最新进展,包括其在纳米纤维、水凝胶、微针和三维打印支架中的应用。报告详细介绍了 ZIF-8 NP 的合成方法、结构特征和理化性质,并强调了它们在促进伤口愈合方面的作用。ZIF-8 在伤口愈合应用中的方法论基础涉及其合成和功能化,以增强生物相容性,从而创建药物输送系统,以可控方式释放生物活性剂,促进组织再生并加速伤口愈合。本综述强调了 ZIF-8 NPs 的生物相容性和生物安全性,指出其在特定浓度范围内的无毒性及其多功能性,如抗菌和消炎作用,可促进血管生成和感染控制。该综述还探讨了将基于 ZIF-8 的纳米复合支架作为改善伤口愈合的下一代材料进行开发和临床转化的当前挑战和未来前景。
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来源期刊
Journal of Polymers and the Environment
Journal of Polymers and the Environment 工程技术-高分子科学
CiteScore
9.50
自引率
7.50%
发文量
297
审稿时长
9 months
期刊介绍: The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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