{"title":"Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review","authors":"Parinaz Nezhad-Mokhtari, Reza Rahbarghazi, Hamed Hamishehkar, Peyman Asadi, Morteza Milani","doi":"10.1007/s10924-024-03398-z","DOIUrl":null,"url":null,"abstract":"<p>Multifunctional nanocomposite scaffolds, particularly those incorporating zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs), are emerging as effective solutions for skin and tissue injuries due to their biocompatibility, structural stability, and antibacterial properties. Integrating ZIF-8 NPs into polymeric scaffolds has significant potential for improved tissue regeneration. This review examines recent advancements in ZIF-8 NP-integrated scaffolds, including their applications in nanofibers, hydrogels, microneedles, and 3D-printable scaffolds. It details the synthesis methods, structural characteristics, and physicochemical properties of ZIF-8 NPs, highlighting their role in enhancing wound healing. The methodological basis of ZIF-8 in wound healing applications involves its synthesis and functionalization to enhance biocompatibility, enabling the creation of drug delivery systems that release bioactive agents in a controlled manner to promote tissue regeneration and accelerate wound healing. This review highlights the biocompatibility and biosafety of ZIF-8 NPs, noting their non-toxic nature within specific concentration ranges and their multifunctional capabilities, such as antibacterial and anti-inflammatory effects that facilitate angiogenesis and infection management. The review also addresses current challenges and future perspectives in developing and clinically translating ZIF-8-based nanocomposite scaffolds as next-generation materials for improving wound healing.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymers and the Environment","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s10924-024-03398-z","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Multifunctional nanocomposite scaffolds, particularly those incorporating zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs), are emerging as effective solutions for skin and tissue injuries due to their biocompatibility, structural stability, and antibacterial properties. Integrating ZIF-8 NPs into polymeric scaffolds has significant potential for improved tissue regeneration. This review examines recent advancements in ZIF-8 NP-integrated scaffolds, including their applications in nanofibers, hydrogels, microneedles, and 3D-printable scaffolds. It details the synthesis methods, structural characteristics, and physicochemical properties of ZIF-8 NPs, highlighting their role in enhancing wound healing. The methodological basis of ZIF-8 in wound healing applications involves its synthesis and functionalization to enhance biocompatibility, enabling the creation of drug delivery systems that release bioactive agents in a controlled manner to promote tissue regeneration and accelerate wound healing. This review highlights the biocompatibility and biosafety of ZIF-8 NPs, noting their non-toxic nature within specific concentration ranges and their multifunctional capabilities, such as antibacterial and anti-inflammatory effects that facilitate angiogenesis and infection management. The review also addresses current challenges and future perspectives in developing and clinically translating ZIF-8-based nanocomposite scaffolds as next-generation materials for improving wound healing.
期刊介绍:
The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.