Real-Time Detection and Synergistic Effect of Acoustic Cavitation Excited by Pulse HIFU Based on Self-Sensing Ultrasound

Abstract

High-intensity focused ultrasound (HIFU) is widely used in the treatment of benign and malignant tumors due to its advantages of noninvasiveness and high therapeutic efficiency. However, how to improve the efficiency of heat deposition in a short period of time is a key problem during HIFU thermal ablation. The acoustic cavitation excited by pulse HIFU has been proven to achieve HIFU efficiency enhancement. However, the real-time monitoring of acoustic cavitation is still an issue. In this study, a real-time detection method of acoustic cavitation is established based on self-sensing ultrasound, and the synergistic effect of acoustic cavitation excited by pulse HIFU is researched. The influences of the output power, pulse duration, irradiation depth on cavitation duration are respectively discussed by using the established cavitation detection method compared passive cavitation detection (PCD). The relationship between cavitation intensity and synergistic effect is discussed. The results have shown that the cavitation detection can real-time measure cavitation duration compared with PCD. In addition, during the cavitation detection of pulse HIFU, the synergistic effect of acoustic cavitation is obvious in HIFU ablation.