Cyclic Diguanylate in the Wild: Roles During Plant and Animal Colonization

IF 8.5 1区 生物学 Q1 MICROBIOLOGY Annual review of microbiology Pub Date : 2024-09-13 DOI:10.1146/annurev-micro-041522-101729
Ruth Y. Isenberg, Mark J. Mandel
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Abstract

Cyclic diguanylate (c-di-GMP) is a near-ubiquitous signaling molecule that regulates the motility-to-sessility transition in many bacterial species. Among the phenotypes influenced by c-di-GMP are biofilm formation, motility, cell cycle, and virulence. The hallmark phenotypes regulated by c-di-GMP—biofilm formation and motility—are key determinants of host–bacterial interactions. A large body of research has identified the roles of c-di-GMP in regulating phenotypes in culture. While numerous studies have investigated roles for c-di-GMP during the establishment and maintenance of pathogenic host–bacterial associations, considerably less attention has been devoted to defining the roles of c-di-GMP during beneficial and commensal associations. This review describes the known roles of c-di-GMP in regulating phenotypes that contribute to host colonization, with a focus on knowledge gaps and future prospects for examining c-di-GMP during beneficial colonization.
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野生环境中的环状二官能团:植物和动物定殖过程中的作用
环状二胍酸盐(c-di-GMP)是一种几乎无处不在的信号分子,可调节许多细菌从运动到无活力的转变。受 c-di-GMP 影响的表型包括生物膜形成、运动性、细胞周期和毒力。受 c-di-GMP 调节的标志性表型--生物膜的形成和运动能力--是宿主与细菌相互作用的关键决定因素。大量研究已经确定了 c-di-GMP 在调节培养物表型中的作用。尽管许多研究都调查了 c-di-GMP 在致病宿主-细菌结合的建立和维持过程中的作用,但对 c-di-GMP 在有益和共生结合过程中的作用的研究却少得多。本综述介绍了 c-di-GMP 在调节有助于宿主定殖的表型方面的已知作用,重点是研究 c-di-GMP 在有益定殖过程中的知识差距和未来前景。
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来源期刊
Annual review of microbiology
Annual review of microbiology 生物-微生物学
CiteScore
18.10
自引率
0.00%
发文量
37
期刊介绍: Annual Review of Microbiology is a Medical and Microbiology Journal and published by Annual Reviews Inc. The Annual Review of Microbiology, in publication since 1947, covers significant developments in the field of microbiology, encompassing bacteria, archaea, viruses, and unicellular eukaryotes. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license. The Impact Factor of Annual Review of Microbiology is 10.242 (2024) Impact factor. The Annual Review of Microbiology Journal is Indexed with Pubmed, Scopus, UGC (University Grants Commission).
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