New europium complexes of C(6)-DTTA-appended 5-aryl-2,2′-bipyridines: synthesis, luminescence, and evaluation of their activity against cell culture

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Russian Chemical Bulletin Pub Date : 2024-09-19 DOI:10.1007/s11172-024-4343-2

A. P. Krinochkin, D. S. Kopchuk, M. I. Valieva, E. S. Starnovskaya, Ya. K. Shtaitz, G. A. Kim, N. V. Slovesnova, A. S. Minin, A. V. Belousova, V. A. Pozdina, I. S. Kovalev, G. V. Zyryanov, A. N. Tsmokalyuk, I. L. Nikonov, V. L. Rusinov

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Abstract

New 5-[4(3)-R-phenyl]-2,2′-bipyridines bearing the 1,1,7,7-tetrakis(tert-butoxycarbonylmethyl)-1,4,7-triazaheptane (DTTA) moiety at the C(6) position (R = Cl, Br, CF₃) and their water-soluble Eu^III complexes were synthesized. The photophysical properties of the synthesized complexes were investigated. More efficient sensitization of Eu³⁺ cation luminescence was demonstrated for a number of halogen-containing ligands. Some chelates exhibited moderate cell-staining ability. The synthesized compounds did not show significant photodynamic activity, which may be due to the inhibition of the in situ generation of reactive oxygen species via the supposed interaction with the methylene moiety of DTTA-appended 2,2′-bipyridine ligands.

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C(6)-DTTA-appended 5-芳基-2,2′-联吡啶的新铕络合物：合成、发光及其对细胞培养的活性评估

合成了新的 5-[4(3)-R-苯基]-2,2′-联吡啶，其 C(6)位含有 1,1,7,7-四(叔丁氧羰基甲基)-1,4,7-三氮杂庚烷 (DTTA)分子（R = Cl、Br、CF3）及其水溶性 EuIII 复合物。研究了合成复合物的光物理特性。结果表明，一些含卤素的配体能更有效地敏化 Eu3+ 阳离子发光。一些螯合物表现出适度的细胞染色能力。合成的化合物没有表现出明显的光动力活性，这可能是由于它们与 DTTA 附加的 2,2′-联吡啶配体的亚甲基相互作用，抑制了活性氧的原位生成。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.