Effortless lab-manufactured carbon and alumina-based composite sensors for enzymeless sensitive amperometric detection of dopamine in clinical and environmental samples

IF 2.6 4区 化学 Q3 ELECTROCHEMISTRY Journal of Solid State Electrochemistry Pub Date : 2024-09-17 DOI:10.1007/s10008-024-06079-y
Guilherme P. Oliveira, Lucas V. de Faria, Natalia M. Caldas, Amanda G. Batista, Suéllen F. L. do Nascimento, Murillo N. T. Silva, Fernanda N. Feiteira, Edson Nossol, Diego P. Rocha, Felipe S. Semaan, Wagner F. Pacheco, Rafael M. Dornellas
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Abstract

Developing new sensors presenting low-cost, portability, and disposability features is of paramount in the electrochemical field. Thus, this work proposes the fabrication of lab-made composite electrodes using acrylonitrile butadiene styrene, graphite, and aluminum oxide. In this investigation, the amount of aluminum oxide (0 to 12.25 w/w) was carefully optimized, and its impact on the electrochemical performance of the electrode was observed using the ferri-ferro redox probe and dopamine (DOP) as a proof of concept. This innovative electrode was characterized by spectroscopy, morphological, elemental, and electrochemical techniques. Using the alumina-loaded electrode, significantly improved cyclic voltammetric responses regarding peak currents and peak-to-peak separation were obtained for both evaluated species. This sensor was integrated into the batch injection analysis system for amperometric monitoring of DOP in synthetic biological fluids (saliva and urine) and tap water. The developed method showed a wide linear range (10 to 1000 µmol L−1), a low detection limit (2.6 µmol L−1), and a high analytical frequency (182 analyses per hour). Furthermore, it was precise (RSD < 5%), accurate (recoveries between 90.5 and 107.3%), and selective. Therefore, it can be considered a low-cost alternative analytical tool for electrochemical sensing of DOP in samples of clinical and environmental interest.

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实验室制造的碳和氧化铝基复合传感器可轻松实现对临床和环境样品中多巴胺的无酶灵敏安培检测
在电化学领域,开发具有低成本、便携性和一次性等特点的新型传感器至关重要。因此,本研究提出使用丙烯腈-丁二烯-苯乙烯、石墨和氧化铝制造实验室自制复合电极。在这项研究中,我们仔细优化了氧化铝的用量(0 至 12.25 w/w),并使用铁-铁氧化还原探针和多巴胺(DOP)作为概念验证,观察了其对电极电化学性能的影响。通过光谱、形态、元素和电化学技术对这种创新电极进行了表征。使用这种负载氧化铝的电极,两种受评估物质的峰值电流和峰峰分离的循环伏安响应都得到了明显改善。该传感器被集成到批量进样分析系统中,用于对合成生物液体(唾液和尿液)和自来水中的 DOP 进行安培监测。所开发的方法线性范围宽(10 至 1000 µmol L-1),检测限低(2.6 µmol L-1),分析频率高(每小时分析 182 次)。此外,它还具有精确性(RSD < 5%)、准确性(回收率在 90.5% 至 107.3% 之间)和选择性。因此,它可被视为电化学检测临床和环境样品中 DOP 的低成本替代分析工具。
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来源期刊
CiteScore
4.80
自引率
4.00%
发文量
227
审稿时长
4.1 months
期刊介绍: The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.
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