A descriptive review on the real-world impact of Moderna, inc. COVID-19 vaccines.

IF 5.5 3区 医学 Q1 IMMUNOLOGY Expert Review of Vaccines Pub Date : 2024-09-13 DOI:10.1080/14760584.2024.2402955
Mary Bausch-Jurken,Rachel S Dawson,Francesca Ceddia,Veronica Urdaneta,Morgan A Marks,Yohei Doi
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Abstract

INTRODUCTION Since the original COVID-19 vaccines were developed, abundant clinical trial and real-world evidence evaluating the efficacy, effectiveness, and safety of COVID-19 vaccines has been collected. Knowledge of the relative benefits and risks of COVID-19 vaccines is essential for building trust within target populations, ensuring they remain effectively and safely protected against an enduring infectious threat. AREAS COVERED This descriptive review discusses the benefits and risks associated with marketed Moderna, Inc. mRNA-based COVID-19 vaccines, focusing on their real-world effectiveness and safety profiles in various age groups. Adverse events of interest and potential benefits of vaccination are reviewed, including reduced risk for severe COVID-19 and long-term health outcomes, reduced economic and societal costs, and reduced risk for SARS-CoV-2 transmission. EXPERT OPINION Post-marketing safety and real-world data for Moderna, Inc. COVID-19 mRNA vaccines strongly support a positive benefit - risk profile favoring vaccination across all age groups. Although COVID-19 is no longer considered a global health pandemic, health risks associated with SARS-CoV-2 infection remain high. Concerted efforts are required to engage communities and maintain protection through vaccination. Continued surveillance of emerging variants and monitoring of vaccine safety and effectiveness are crucial for ensuring sustained protection against SARS-CoV-2.
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关于 Moderna, inc.COVID-19 疫苗的实际影响的描述性综述。
简介自最初开发 COVID-19 疫苗以来,已经收集了大量临床试验和真实世界的证据来评估 COVID-19 疫苗的效力、有效性和安全性。了解 COVID-19 疫苗的相对益处和风险对于在目标人群中建立信任至关重要,可确保他们得到有效、安全的保护,免受持久的传染病威胁。 本描述性综述讨论了与已上市的 Moderna 公司基于 mRNA 的 COVID-19 疫苗相关的益处和风险,重点关注其在不同年龄段的实际有效性和安全性。专家意见:Moderna, Inc. COVID-19 mRNA 疫苗上市后的安全性和真实世界数据表明,该疫苗可降低严重 COVID-19 和长期健康后果的风险,降低经济和社会成本,并降低 SARS-CoV-2 传播的风险。COVID-19 mRNA 疫苗上市后的安全性和真实世界数据有力地证明了接种疫苗对所有年龄组都有积极的收益-风险分析。尽管 COVID-19 已不再被认为是全球健康大流行病,但与 SARS-CoV-2 感染相关的健康风险仍然很高。需要共同努力让社区参与进来,并通过接种疫苗保持保护。对新出现的变种进行持续监测以及对疫苗的安全性和有效性进行监控,对于确保持续预防 SARS-CoV-2 至关重要。
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来源期刊
Expert Review of Vaccines
Expert Review of Vaccines 医学-免疫学
CiteScore
9.10
自引率
3.20%
发文量
136
审稿时长
4-8 weeks
期刊介绍: Expert Review of Vaccines (ISSN 1476-0584) provides expert commentary on the development, application, and clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines for defence against bioterrorism. All articles are subject to rigorous peer-review. The vaccine field has been transformed by recent technological advances, but there remain many challenges in the delivery of cost-effective, safe vaccines. Expert Review of Vaccines facilitates decision making to drive forward this exciting field.
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