A comprehensive review of Co3O4 nanostructures in cancer: Synthesis, characterization, reactive oxygen species mechanisms, and therapeutic applications
{"title":"A comprehensive review of Co3O4 nanostructures in cancer: Synthesis, characterization, reactive oxygen species mechanisms, and therapeutic applications","authors":"","doi":"10.1016/j.biopha.2024.117457","DOIUrl":null,"url":null,"abstract":"<div><p>Nanotechnology involves creating, analyzing, and using tiny materials. Cobalt oxide nanoparticles (Co<sub>3</sub>O<sub>4</sub> NPs) have several medicinal uses due to their unique antifungal, antibacterial, antioxidant, anticancer, larvicidal, anticholinergic, antileishmanial, wound healing, and antidiabetic capabilities. Cobalt oxide nanoparticles (Co<sub>3</sub>O<sub>4</sub> NPs) with attractive magnetic properties have found widespread use in biomedical applications, including magnetic resonance imaging, magnetic hyperthermia, and magnetic targeting. The high surface area of Co<sub>3</sub>O<sub>4</sub> leads to unique electrical, optical, catalytic, and magnetic properties, which make it a promising candidate for biomedical bases. Additionally, cobalt nanoparticles with various oxidation states (i.e., Co<sup>2+</sup>, Co<sup>3+</sup>, and Co<sup>4+</sup>) are beneficial in numerous utilizations. Co<sub>3</sub>O<sub>4</sub> nanoparticles as a catalyzer accelerate the conversion rate of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) to harmful hydroxyl radicals (<sup>•</sup>OH), which destroy tumor cells. However, it is also possible to enhance the generation of reactive oxygen species (ROS) and successfully treat cancer by combining these nanoparticles with drugs or other nanoparticles. This review summarizes the past concepts and discusses the present state and development of using Co<sub>3</sub>O<sub>4</sub> NPs in cancer treatments by ROS generation. This review emphasizes the advances and current patterns in ROS generation, remediation, and some different cancer treatments using Co<sub>3</sub>O<sub>4</sub> nanoparticles in the human body. It also discusses synthesis techniques, structure, morphological, optical, and magnetic properties of Co<sub>3</sub>O<sub>4</sub> NPs.</p></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":6.9000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S075333222401343X/pdfft?md5=d6115a8ffad4a98b94f859a2cd8ac2b2&pid=1-s2.0-S075333222401343X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Pharmacotherapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S075333222401343X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Nanotechnology involves creating, analyzing, and using tiny materials. Cobalt oxide nanoparticles (Co3O4 NPs) have several medicinal uses due to their unique antifungal, antibacterial, antioxidant, anticancer, larvicidal, anticholinergic, antileishmanial, wound healing, and antidiabetic capabilities. Cobalt oxide nanoparticles (Co3O4 NPs) with attractive magnetic properties have found widespread use in biomedical applications, including magnetic resonance imaging, magnetic hyperthermia, and magnetic targeting. The high surface area of Co3O4 leads to unique electrical, optical, catalytic, and magnetic properties, which make it a promising candidate for biomedical bases. Additionally, cobalt nanoparticles with various oxidation states (i.e., Co2+, Co3+, and Co4+) are beneficial in numerous utilizations. Co3O4 nanoparticles as a catalyzer accelerate the conversion rate of hydrogen peroxide (H2O2) to harmful hydroxyl radicals (•OH), which destroy tumor cells. However, it is also possible to enhance the generation of reactive oxygen species (ROS) and successfully treat cancer by combining these nanoparticles with drugs or other nanoparticles. This review summarizes the past concepts and discusses the present state and development of using Co3O4 NPs in cancer treatments by ROS generation. This review emphasizes the advances and current patterns in ROS generation, remediation, and some different cancer treatments using Co3O4 nanoparticles in the human body. It also discusses synthesis techniques, structure, morphological, optical, and magnetic properties of Co3O4 NPs.
期刊介绍:
Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.