Numerical simulations of a two-strain dengue model to investigate the efficacy of the deployment of Wolbachia-carrying mosquitoes and vaccination for reducing the incidence of dengue infections

Q1 Social Sciences Journal of Biosafety and Biosecurity Pub Date : 2024-09-05 DOI:10.1016/j.jobb.2024.08.003

Meksianis Z. Ndii , Nursanti Anggriani , Bertha S. Djahi , Sanubari Tansah Tresna , Fatuh Inayaturohmat

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Abstract

This study investigated the usefulness of a two-serotype dengue mathematical model to gain insights into the effects of antibody-dependent enhancement and temperature on dengue transmission dynamics in the presence of vaccination and Wolbachia-carrying mosquitoes. In particular, the effects of temperature on the mosquito death and maturation rates in secondary infections were examined. A deterministic mathematical model was formulated and analysed to address this problem. The results suggest that controlling the population of aquatic mosquitoes is appropriate for reducing the incidence of secondary infections. Furthermore, the wAu Wolbachia strain was more effective in reducing secondary infections.

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对双菌株登革热模型进行数值模拟，研究部署携带沃尔巴克氏体的蚊子和接种疫苗对降低登革热感染率的功效

这项研究调查了登革热双倍型数学模型的实用性，以深入了解在接种疫苗和携带沃尔巴克氏体蚊子的情况下，抗体依赖性增强和温度对登革热传播动态的影响。特别是，研究了温度对二次感染中蚊子死亡率和成熟率的影响。为解决这一问题，建立并分析了一个确定性数学模型。结果表明，控制水生蚊子的数量可减少二次感染的发生率。此外，wAu Wolbachia 菌株在减少二次感染方面更为有效。

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