{"title":"Di(2-picolyl)amine appended luminescent probes: Advances in bioimaging and therapeutics","authors":"Bishnu Das, Parna Gupta","doi":"10.1016/j.ccr.2024.216209","DOIUrl":null,"url":null,"abstract":"<div><p>Di(2-picolyl)amine appended luminescent probes have been developed as versatile tools for bioimaging and therapeutic applications. These probes offer real-time monitoring and visualization of metal ions, anions, and biomolecules in cellular systems. Specifically, it covers the detection and monitoring of metal ions such as Cu<sup>2+</sup>, Zn<sup>2+</sup>, Fe<sup>2+</sup>, Fe<sup>3+</sup>, Co<sup>2+</sup>, Ni<sup>2+</sup>, Hg<sup>2+</sup>, Cd<sup>2+</sup>, Al<sup>3+</sup>, Ag<sup>+</sup>, Pb<sup>2+</sup> as well as anions including CN<sup>−</sup>, S<sup>2−</sup>, PO<sub>4</sub><sup>3−</sup>, pyrophosphate. Furthermore, the utility of DPA-based probes in detecting maleic acid, and various biomolecules is highlighted. Additionally, the specific binding properties of DPA have been exploited in therapeutic applications, leading to advancements in targeted therapeutics. This review emphasizes recent developments in DPA-appended luminescent probes for bioimaging and therapeutics.</p></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"522 ","pages":"Article 216209"},"PeriodicalIF":20.3000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010854524005551","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Di(2-picolyl)amine appended luminescent probes have been developed as versatile tools for bioimaging and therapeutic applications. These probes offer real-time monitoring and visualization of metal ions, anions, and biomolecules in cellular systems. Specifically, it covers the detection and monitoring of metal ions such as Cu2+, Zn2+, Fe2+, Fe3+, Co2+, Ni2+, Hg2+, Cd2+, Al3+, Ag+, Pb2+ as well as anions including CN−, S2−, PO43−, pyrophosphate. Furthermore, the utility of DPA-based probes in detecting maleic acid, and various biomolecules is highlighted. Additionally, the specific binding properties of DPA have been exploited in therapeutic applications, leading to advancements in targeted therapeutics. This review emphasizes recent developments in DPA-appended luminescent probes for bioimaging and therapeutics.
期刊介绍：
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.
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