Duration of Breastfeeding and Risk Reduction of Breast Cancer among Mothers Who Have Ever Breastfed: A Case-Control Study Conducted in Bahir Dar, Ethiopia

IF 1.9 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Breast Journal Pub Date : 2024-09-20 DOI:10.1155/2024/1987378
Fentanesh Nibret Tiruneh, Peter Austin Morton Ntenda
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Abstract

Introduction. Breast cancer is currently the most frequently detected cancer in women and the primary cause of cancer-related deaths globally. The incidence of breast cancer has significantly increased in countries across sub-Saharan Africa, counting Ethiopia. There are multiple determinants of breast cancer, a few of these can be changeable whereas others are not. Evidence suggests that breastfeeding, which is a changeable determinant, reduces breast cancer risk. However, there is a lack of evidence specifically linking the duration of breastfeeding to breast cancer risk. To date, no study has been conducted on the association between the duration of breastfeeding and the likelihood of breast cancer among Ethiopian women. Objective. The aim of this study was to evaluate the relationship between breastfeeding duration and breast cancer risk in Ethiopian mothers who had breastfed, taking into account other significant determinants. Methods. A hospital-based case-control study was carried out in Bahir Dar, Ethiopia, involving 203 women (70 cases and 133 controls). Face-to-face interviews were performed using a standardized, validated questionnaire that assessed various sociodemographic, reproductive, lifestyle, and dietary characteristics. Differences between cases and controls were evaluated using the chi-square test. The associations among factors were examined through bivariate and multivariable binary logistic regression, with results presented as odds ratios and 95% confidence intervals. Results. The multivariable investigation revealed that an inverse relationship between breastfeeding duration and breast cancer risk. Mothers who breastfed for a longer period had a 93% lower risk of breast cancer (AOR = 0.07; 95% CI: 0.021–0.21) compared to those who breastfed for a shorter duration. Younger mothers had a 95% lower likelihood of developing breast cancer (AOR = 0.05; 95% CI: 0.003–0.91) than older mothers. Additionally, mothers with sedentary behaviour were 10.53 times more likely to develop breast cancer (AOR = 10.53; 95% CI: 5.21–21.36) than those who were moderately or highly active. Mothers who experienced chest therapy were 6.43 times more likely to develop breast cancer (AOR = 6.43; 95% CI: 3.20–13.90) compared to those who had not. Conclusions. Interventions such as breastfeeding counselling and promoting the recommended duration of breastfeeding are crucial in minimizing the risk of breast cancer. Enhancing physical activity should also be viewed as a vital approach for lowering breast cancer risk. Additionally, healthcare professionals need to limit exposure to chest radiation therapy to reduce the likelihood of breast cancer.

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母乳喂养持续时间与降低母乳喂养母亲患乳腺癌的风险:在埃塞俄比亚巴哈达尔进行的病例对照研究
导言。乳腺癌是目前妇女最常发现的癌症,也是全球癌症相关死亡的主要原因。在撒哈拉以南非洲国家(包括埃塞俄比亚),乳腺癌的发病率大幅上升。乳腺癌有多种决定因素,其中一些可以改变,而另一些则无法改变。有证据表明,母乳喂养这一可改变的决定因素可降低乳腺癌风险。然而,目前还缺乏将母乳喂养时间与乳腺癌风险具体联系起来的证据。迄今为止,尚未对埃塞俄比亚妇女母乳喂养持续时间与乳腺癌发病几率之间的关系进行过研究。研究目的本研究旨在评估埃塞俄比亚母乳喂养母亲的母乳喂养持续时间与乳腺癌风险之间的关系,同时考虑其他重要的决定因素。研究方法在埃塞俄比亚巴哈达尔市开展了一项基于医院的病例对照研究,共有 203 名妇女参与(70 例病例和 133 例对照)。研究人员使用标准化的验证问卷进行了面对面访谈,评估了各种社会人口、生殖、生活方式和饮食特征。病例与对照组之间的差异采用卡方检验进行评估。通过二元和多变量二元逻辑回归检验了各因素之间的关联,结果以几率比和 95% 置信区间表示。结果显示多变量调查显示,母乳喂养时间与乳腺癌风险呈反比关系。与母乳喂养时间较短的母亲相比,母乳喂养时间较长的母亲患乳腺癌的风险低 93%(AOR = 0.07;95% CI:0.021-0.21)。年轻母亲患乳腺癌的可能性比年长母亲低 95%(AOR = 0.05;95% CI:0.003-0.91)。此外,久坐不动的母亲患乳腺癌的几率(AOR = 10.53;95% CI:5.21-21.36)是中度或高度活跃母亲的 10.53 倍。经历过胸部治疗的母亲患乳腺癌的几率是没有经历过胸部治疗的母亲的 6.43 倍(AOR = 6.43;95% CI:3.20-13.90)。结论母乳喂养咨询和提倡建议的母乳喂养时间等干预措施对于最大限度地降低乳腺癌风险至关重要。加强体育锻炼也应被视为降低乳腺癌风险的重要方法。此外,医护人员需要限制接受胸部放射治疗,以降低罹患乳腺癌的可能性。
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来源期刊
Breast Journal
Breast Journal 医学-妇产科学
CiteScore
4.00
自引率
0.00%
发文量
47
审稿时长
4-8 weeks
期刊介绍: The Breast Journal is the first comprehensive, multidisciplinary source devoted exclusively to all facets of research, diagnosis, and treatment of breast disease. The Breast Journal encompasses the latest news and technologies from the many medical specialties concerned with breast disease care in order to address the disease within the context of an integrated breast health care. This editorial philosophy recognizes the special social, sexual, and psychological considerations that distinguish cancer, and breast cancer in particular, from other serious diseases. Topics specifically within the scope of The Breast Journal include: Risk Factors Prevention Early Detection Diagnosis and Therapy Psychological Issues Quality of Life Biology of Breast Cancer.
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