4-hydroxybenzoic acid specific fluorescent sensor based on N,S-doped carbon dots@molecularly imprinted polymer

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2024-08-16 DOI:10.1016/j.dyepig.2024.112411

引用次数: 0

Abstract

4-Hydroxybenzoic acid is one of the important metabolism biochemical markers of the urine in gastric cancer patients. In this work, a fluorescence sensor based on N,S-doped carbon dots conjugated molecular imprinting polymers (N,S-CDs@SiO₂@MIPs) was prepared to detect4-hydroxybenzoic acid. The novel fluorescence sensor in response to 4-hydroxybenzoic acid ranged from 0 to 100 μmol/L, with a detection limit of 1.27 μmol/L. Furthermore, 4-hydroxybenzoic acid demonstrated strong fluorescence quenching capability on our fluorescence sensor, with the fluorescence quenching mechanism involving a combined effects of dynamic quenching and electron transfer. Lastly, the N,S-CDs@SiO₂@MIPs were applied to analyze 4-hydroxybenzoic acid inhuman urine samples with high accuracy. The findings showed that N,S-CDs@SiO₂@MIPs sensor might have high potential for effectively, selectively, accurately diagnosing gastric cancer patients.

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基于 N、S 掺杂碳点@分子印迹聚合物的 4-羟基苯甲酸特异性荧光传感器

4-羟基苯甲酸是胃癌患者尿液中重要的代谢生化指标之一。本研究制备了一种基于 N,S-掺杂碳点共轭分子印迹聚合物（N,S-CDs@SiO2@MIPs）的荧光传感器，用于检测对羟基苯甲酸。新型荧光传感器对 4-羟基苯甲酸的响应范围为 0 至 100 μmol/L，检测限为 1.27 μmol/L。此外，4-羟基苯甲酸在我们的荧光传感器上具有很强的荧光淬灭能力，其荧光淬灭机制涉及动态淬灭和电子转移的综合效应。最后，研究人员将 N,S-CDs@SiO2@MIPs 应用于分析人体尿液中的 4-羟基苯甲酸，结果表明，N,S-CDs@SiO2@MIPs 具有较高的准确度。研究结果表明，N,S-CDs@SiO2@MIPs 传感器在有效、选择性、准确诊断胃癌患者方面具有很大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.