Ascorbyl palmitate nanofiber-reinforced hydrogels for drug delivery in soft issues

IF 7.5 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Communications Materials Pub Date : 2024-09-20 DOI:10.1038/s43246-024-00641-x
Yasmeen Shamiya, Aishik Chakraborty, Alap Ali Zahid, Nicholas Bainbridge, Jingyuan Guan, Biao Feng, Dominic Pjontek, Subrata Chakrabarti, Arghya Paul
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Abstract

Nanofiber-based hydrogel delivery systems have recently shown great potential in biomedical applications, specifically due to their high surface-to-volume ratio of ultra-fine nanofibers and their ability to carry low solubility drugs. Herein, we introduce a visible light-triggered in situ-gelling drug vehicle (GAP Gel) composed of ascorbyl palmitate (AP) nanofibers and gelatin methacryloyl polymer. AP nanofibers form self-assembled structures through intermolecular interactions with a hydrophobic drug-loading core. We demonstrate that the hydrophilic periphery of AP nanofibers allows them to interact with other hydrophilic molecules via hydrogen bonds. The presence of AP nanofibers significantly enhances the viscoelasticity of GAP Gel in a concentration-dependent manner. Further, GAP Gel shows in vitro biocompatibility and sustained drug delivery efficacy when loaded with a hydrophobic antibiotic. Likewise, GAP Gel shows excellent in vivo biocompatibility when implanted in immunocompetent mice in various forms. Lastly, GAP Gels maintain cell viability when cultured in a 3D-environment over 7 days, establishing it as a promising and versatile hydrogel platform for the delivery of biotherapeutics. Nanofiber-based hydrogels are useful delivery systems in biomedical applications due to their drug loading capability and controlled release. Here, a biocompatible visible light-triggered in situ-gelling drug delivery system is demonstrated consisting of ascorbyl palmitate nanofibers and gelatin methacryloyl polymer.

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用于软问题药物输送的抗坏血酸棕榈酸酯纳米纤维增强水凝胶
基于纳米纤维的水凝胶给药系统最近在生物医学应用中显示出巨大的潜力,特别是由于其超细纳米纤维的高表面体积比和携带低溶解度药物的能力。在此,我们介绍一种由抗坏血酸棕榈酸酯(AP)纳米纤维和明胶甲基丙烯酰聚合物组成的可见光触发原位胶凝药物载体(GAP Gel)。抗坏血酸棕榈酸酯(AP)纳米纤维通过分子间相互作用与疏水性载药核心形成自组装结构。我们证明,AP 纳米纤维的亲水性外围使其能够通过氢键与其他亲水性分子相互作用。AP 纳米纤维的存在以浓度依赖的方式显著增强了 GAP 凝胶的粘弹性。此外,GAP 凝胶在负载疏水性抗生素时显示出体外生物相容性和持续给药效果。同样,当 GAP 凝胶以各种形式植入免疫功能正常的小鼠体内时,也显示出良好的体内生物相容性。最后,GAP 凝胶在三维环境中培养 7 天后仍能保持细胞活力,从而使其成为一种前景广阔的多功能水凝胶平台,用于输送生物治疗药物。基于纳米纤维的水凝胶具有药物负载能力和可控释放特性,是生物医学应用中非常有用的递送系统。本文展示了一种由抗坏血酸棕榈酸酯纳米纤维和明胶甲基丙烯酰聚合物组成的生物相容性可见光触发原位胶凝给药系统。
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来源期刊
Communications Materials
Communications Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
12.10
自引率
1.30%
发文量
85
审稿时长
17 weeks
期刊介绍: Communications Materials, a selective open access journal within Nature Portfolio, is dedicated to publishing top-tier research, reviews, and commentary across all facets of materials science. The journal showcases significant advancements in specialized research areas, encompassing both fundamental and applied studies. Serving as an open access option for materials sciences, Communications Materials applies less stringent criteria for impact and significance compared to Nature-branded journals, including Nature Communications.
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