Pasteurella Infections in South Korea and Systematic Review and Meta-analysis of Pasteurella Bacteremia

IF 7.2 2区医学 Q1 IMMUNOLOGY Emerging Infectious Diseases Pub Date : 2024-09-23 DOI:10.3201/eid3010.240245

Seri Jeong, Eunjin Chang, Nuri Lee, Hyun Soo Kim, Han-Sung Kim, Jae-Seok Kim, Young Ah Kim, Chang Ki Kim, Kyungwon Lee, Hyukmin Lee, Seok Hoon Jeong, Wonkeun Song

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Abstract

Pasteurella spp. can cause fatal zoonotic infections in humans. We performed a multicenter study to investigate the prevalence and clinical features of Pasteurella infections in South Korea during 2018‒2022. We also conducted a collaborative systematic review and meta-analysis of the global burden of Pasteurella bacteremia. The study included 283 cases found an increasing trend in Pasteurella infections. Blood cultures were positive in 8/35 (22.9%) cases sampled, for overall bacteremia-associated rate of 2.8% (8/283). Aging was a significant risk factor for bacteremia (odds ratio 1.05 [95% CI 1.01–1.10]), according to multivariate analyses. For the meta-analysis, we included a total of 2,012 cases from 10 studies. The pooled prevalence of bacteremia was 12.4% (95% CI 7.3%–18.6%) and of mortality 8.4% (95% CI 2.7%–16.5%). Our findings reflect the need for greater understanding of the increase in Pasteurella infections and the global burden of Pasteurella bacteremia to determine appropriate case management.

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韩国的巴氏杆菌感染以及巴氏杆菌菌血症的系统回顾和元分析

巴氏杆菌可导致人类致命的人畜共患感染。我们开展了一项多中心研究，调查2018-2022年韩国巴氏杆菌感染的流行率和临床特征。我们还对巴氏杆菌菌血症的全球负担进行了合作性系统回顾和荟萃分析。研究共纳入 283 例病例，发现巴氏杆菌感染呈上升趋势。8/35（22.9%）个采样病例的血液培养呈阳性，与菌血症相关的总比率为 2.8%（8/283）。根据多变量分析，年龄是导致菌血症的重要风险因素（几率比 1.05 [95% CI 1.01-1.10]）。在荟萃分析中，我们共纳入了来自 10 项研究的 2,012 个病例。汇总的菌血症发病率为 12.4%（95% CI 7.3%-18.6%），死亡率为 8.4%（95% CI 2.7%-16.5%）。我们的研究结果表明，需要进一步了解巴氏杆菌感染的增加情况和巴氏杆菌菌血症的全球负担，以确定适当的病例管理。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.