{"title":"Dye self-organization in doped silica nanoparticles increases the electrochemiluminescence emission in magnetic bead-based assays†","authors":"Yemataw Addis Alemu , Marinella Difonzo , Damiano Genovese , Francesco Paolucci , Luca Prodi , Enrico Rampazzo , Giovanni Valenti","doi":"10.1039/d4cc03488k","DOIUrl":null,"url":null,"abstract":"<div><div>We have investigated the effect of dye distribution on the electrochemiluminescence (ECL) intensity measured with a simplified magnetic bead-based immunoassay for two families of silica nanoparticles (NPs) doped with the cationic Ru(bpy)<sub>3</sub><sup>2+</sup> and the zwitterionic Ru(bpy)<sub>2</sub>bps complexes (bps = bathophenanthroline disulfonate). The NPs doped with the Ru(bpy)<sub>2</sub>bps complex, which can efficiently self-organize in the NP volume favoring ECL generation, resulted in 150–400% signal enhancement compared to the Ru(bpy)<sub>3</sub><sup>2+</sup>-doped ones.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"60 83","pages":"Pages 11936-11939"},"PeriodicalIF":4.2000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/cc/d4cc03488k?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734524019852","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
We have investigated the effect of dye distribution on the electrochemiluminescence (ECL) intensity measured with a simplified magnetic bead-based immunoassay for two families of silica nanoparticles (NPs) doped with the cationic Ru(bpy)32+ and the zwitterionic Ru(bpy)2bps complexes (bps = bathophenanthroline disulfonate). The NPs doped with the Ru(bpy)2bps complex, which can efficiently self-organize in the NP volume favoring ECL generation, resulted in 150–400% signal enhancement compared to the Ru(bpy)32+-doped ones.
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