Dye self-organization in doped silica nanoparticles increases the electrochemiluminescence emission in magnetic beads-based assay

IF 4.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemical Communications Pub Date : 2024-09-23 DOI:10.1039/d4cc03488k
Yemataw Addis Alemu, Marinella Difonzo, Damiano Genovese, Francesco Paolucci, Luca Prodi, ENRICO RAMPAZZO, Giovanni Valenti
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Abstract

We have investigated the effect of dye distribution on the electrochemiluminescence (ECL) intensity measured with a simplified magnetic beads-based immunoassay for two families of silica nanoparticles (NPs) doped with the cationic Ru(bpy)32+ and the zwitterionic Ru(bpy)2bps complexes (bps = bathophenanthroline disulfonate). The NPs doped with the Ru(bpy)2bps complex - which can efficiently self-organize in the NP volume favoring the ECL generation - resulted in 150-400% signal enhancement compared to the Ru(bpy)32+ doped ones.
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掺杂二氧化硅纳米粒子中的染料自组织提高了磁珠检测中的电化学发光发射率
我们研究了掺杂阳离子 Ru(bpy)32+ 和齐聚离子 Ru(bpy)2bps 复合物(bps=浴菲罗啉二磺酸盐)的两个系列硅纳米粒子(NPs)的染料分布对基于简化磁珠的免疫分析法测量的电化学发光(ECL)强度的影响。掺杂了 Ru(bpy)2bps 复合物的 NPs 能在 NP 体积中有效自组织,有利于 ECL 的生成,与掺杂了 Ru(bpy)32+ 的 NPs 相比,信号增强了 150-400%。
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍: ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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